Results 11 to 20 of about 24,253,925 (274)
Proteolytic cleavage of Beclin 1 exacerbates neurodegeneration [PDF]
Molecular Neurodegeneration, 2018 Background Neuronal cell loss contributes to the pathology of acute and chronic neurodegenerative diseases, including Alzheimer’s disease (AD). It remains crucial to identify molecular mechanisms sensitizing neurons to various insults and cell death.
Gregor Bieri +5 more
doaj +3 more sources
Beclin 1, LC3 and P62 Expression in Equine Sarcoids [PDF]
Animals, 2021 Background: It is well known that δ-bovine papillomaviruses (BPV-1, BPV-2 and BPV-13) are one of the major causative agents of equine sarcoids, the most common equine skin tumors.
Manuela Martano +6 more
doaj +4 more sources
Beclin-1 Targeting for Viral Immune Escape [PDF]
Viruses, 2011 Macroautophagy is a catabolic pathway in eukaryotic cells that has recently been shown to facilitate pathogen detection, pathogen restriction and pathogen-derived antigen presentation to CD4+ T cells.
Christian Münz
doaj +4 more sources
Beclin-1-Dependent Autophagy Protects the Heart During Sepsis [PDF]
Circulation, 2018 Background: Cardiac dysfunction is a major component of sepsis-induced multiorgan failure in critical care units. Changes in cardiac autophagy and its role during sepsis pathogenesis have not been clearly defined.
Yuxiao Sun +14 more
semanticscholar +3 more sources
The Beclin 1 network regulates autophagy and apoptosis [PDF]
Cell Death & Differentiation, 2011 Beclin 1, the mammalian orthologue of yeast Atg6, has a central role in autophagy, a process of programmed cell survival, which is increased during periods of cell stress and extinguished during the cell cycle. It interacts with several cofactors (Atg14L, UVRAG, Bif-1, Rubicon, Ambra1, HMGB1, nPIST, VMP1, SLAM, IP(3)R, PINK and survivin) to regulate ...
R. Kang, H. J. Zeh, M. Lotze, D. Tang
semanticscholar +3 more sources
Cells, 2023 Background: Gliomas are the most malignant tumors of the central nervous system. One of the factors in their high drug resistance is avoiding programmed death (PCD) induction. This is related to the overexpression of intracellular survival pathways: PI3K-
Adrian Zając +12 more
semanticscholar +1 more source
Expression of Beclin Family Proteins Is Associated with Tumor Progression in Oral Cancer. [PDF]
PLoS ONE, 2015 Beclin 1 and Beclin 2 are autophagy-related proteins that show similar amino acid sequences and domain structures. Beclin 1 established the first connection between autophagy and cancer. However, the role of Beclin 2 in cancer is unclear.
Jing-Lan Liu +8 more
doaj +1 more source
Beclin 1 is required for neuron viability and regulates endosome pathways via the UVRAG-VPS34 complex. [PDF]
PLoS Genetics, 2014 Deficiency of autophagy protein beclin 1 is implicated in tumorigenesis and neurodegenerative diseases, but the molecular mechanism remains elusive. Previous studies showed that Beclin 1 coordinates the assembly of multiple VPS34 complexes whose distinct
Nicole C McKnight +9 more
doaj +1 more source
Tumor-suppressor function of Beclin 1 in breast cancer cells requires E-cadherin
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Beclin 1, an essential autophagy protein, is important for tumor suppression in mice, as well as in human breast and ovarian cancers. However, it is not well understood how Beclin 1 acts as a tumor suppressor.
Tobias Wijshake +8 more
semanticscholar +1 more source
Beclin-1 expression is a significant predictor of survival in patients with lymph node-positive gastric cancer. [PDF]
PLoS ONE, 2012 Beclin 1 is a main actor of autophagy. The expression of Beclin 1 and its prognostic role in gastric cancer is largely unexplored. The purpose of the present study is to investigate the expression of beclin 1 in gastric cancer cells, tissues and its ...
Qi-Rong Geng +6 more
doaj +1 more source