Results 171 to 180 of about 28,669,523 (277)

Integrating behavioural science and epidemiology to improve early detection of zoonotic swine influenza in the Netherlands. [PDF]

One Health
Fraser J, Pacholewicz E, Hobbelen P, Hagenaars T, Bergevoet R, Counotte M.   +5 more
europepmc   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

What barriers need to be removed to incorporate resistance exercise into the lives of older adults with long-term diabetes and prefrailty? A deductive framework analysis using the Capability, Opportunity, Motivation and Behaviour (COM-B) behavioural science model. [PDF]

Diabet Med
Stocker R, Russell S, Taylor GS, Witham MD, Shaw JAM, West DJ.   +5 more
europepmc   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Predicting the replicability of social and behavioural science claims in COVID-19 preprints. [PDF]

Nat Hum Behav
Marcoci A, Wilkinson DP, Vercammen A, Wintle BC, Abatayo AL, Baskin E, Berkman H, Buchanan EM, Capitán S, Capitán T, Chan G, Cheng KJG, Coupé T, Dryhurst S, Duan J, Edlund JE, Errington TM, Fedor A, Fidler F, Field JG, Fox N, Fraser H, Freeman ALJ, Hanea A, Holzmeister F, Hong S, Huggins R, Huntington-Klein N, Johannesson M, Jones AM, Kapoor H, Kerr J, Kline Struhl M, Kołczyńska M, Liu Y, Loomas Z, Luis B, Méndez E, Miske O, Mody F, Nast C, Nosek BA, Simon Parsons E, Pfeiffer T, Reed WR, Roozenbeek J, Schlyfestone AR, Schneider CR, Soh A, Song Z, Tagat A, Tutor M, Tyner AH, Urbanska K, van der Linden S.   +54 more
europepmc   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Evaluating musculoskeletal imaging communication interventions using behavioural science: a scoping review using the COM-B model. [PDF]

BMJ Open
Kirby E, MacMillan A, Brinkley A, X W Liew B, Bateman A.   +4 more
europepmc   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source