Results 181 to 190 of about 28,669,523 (277)

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Can large language models help predict results from a complex behavioural science study? [PDF]

R Soc Open Sci
Lippert S, Dreber A, Johannesson M, Tierney W, Cyrus-Lai W, Uhlmann EL, Emotion Expression Collaboration, Pfeiffer T.   +7 more
europepmc   +1 more source

A scoping review of behavioural science approaches and frameworks for health protection and emergency response

, 2023
Zelenka Martin A, Weston D, Kesten J, French C.   +3 more
europepmc   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Tackling unmanaged oropharyngeal dysphagia in primary care: a behavioural science realist review of interventions. [PDF]

BMJ Open
Smith C, Bhattacharya D, Hansjee D, Jeffries C, Richards K, Scott S.   +5 more
europepmc   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

To use or not to use behavioural science evidence in designing health promotion interventions: Identification of targets for capacity building. [PDF]

Can J Public Health
Bélanger-Gravel A, Lavoie KL, Desroches S, Barnett TA, Paquette MC, Therrien F, Gauvin L.   +6 more
europepmc   +1 more source

Evaluating GenAI‐produced feedback on undergraduate bioscience essays against good higher education feedback practice

FEBS Open Bio, EarlyView.
This pilot study investigates the potential of Generative AI to provide formative feedback to students. ChatGPT was prompted to provide feedback on Year 1 Bioscience essays, which were evaluated against established good feedback practices. GenAI‐authored feedback had useful elements, but was limited in scope. GenAI may have potential to provide instant,
Annabel Court, Nigel Francis, Andrew Shore, Stephen Rutherford   +3 more
wiley   +1 more source

A scoping review of behavioural science approaches and frameworks for health protection and emergency response. [PDF]

Perspect Public Health
Zelenka Martin A, Weston D, Kesten JM, French CE.   +3 more
europepmc   +1 more source

How fast is fast enough? Academic behavioural science impacting public health policy and practice

, 2023
Hubbard G, Dixon D, Johnston M, Maier M, den Daas C.   +4 more
europepmc   +1 more source