Results 71 to 80 of about 28,669,523 (277)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Youth’s social network structures and peer influences: study protocol MyMovez project – Phase I

BMC Public Health, 2018
Background Youth are an important target group for social network interventions, because they are particularly susceptible to the adaptation of healthy and unhealthy habits and behaviors of others.
Kirsten E. Bevelander, Crystal R. Smit, Thabo J. van Woudenberg, Laura Buijs, William J. Burk, Moniek Buijzen   +5 more
doaj   +1 more source

Behavioural science and chronic pain [PDF]

Postgraduate Medical Journal, 1984
Viewing chronic pain from the perspective of behavioural science requires consideration first of conceptual models. We develop theories or conceptual models to assist in ordering observations into more coherent patterns. We sometimes fail, however, to distinguish between models or theories and statements of fact.
openaire   +2 more sources

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

A randomized controlled trial testing a social network intervention to promote physical activity among adolescents

BMC Public Health, 2018
Background The current study examined the effectiveness of a social network intervention to promote physical activity among adolescents. Social network interventions utilize peer influence to change behavior by identifying the most influential ...
Thabo J. van Woudenberg, Kirsten E. Bevelander, William J. Burk, Crystal R. Smit, Laura Buijs, Moniek Buijzen   +5 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Towards Behavioural Computer Science

, 2016
The rapidly increasing pervasiveness and integration of computers in human and animal society calls for a broad discipline under which this development can be studied. We argue that to design and use technology one needs to develop and use models of humans/animals and machines in all their aspects, including cognitive and memory models, but also social
Christian Johansen, Tore Pedersen, Audun Jøsang   +2 more
openaire   +3 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Can ‘Script Elicitation’ Methods Be Used to Promote Physical Activity? An Acceptability Study

Behavioral Sciences
Sustaining physical activity may require incorporating activity into everyday routines. Yet, many such routines are executed habitually, so people may not recognise physical activity opportunities. ‘Script Elicitation’—a novel intervention method whereby
William Peer, Ruth R. Mathews, Xueli Ng, Winson Ho Chun Wong, Benjamin Gardner   +4 more
doaj   +1 more source