Results 81 to 90 of about 28,669,523 (277)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Cognitive maps examples for behavioural science journal

, 2019
Cognitive maps examples for behavioural science ...
Mehmetoglu, Ezgi, Mehmetoglu, Ezgi (8041499)   +1 more
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

A Population Survey on Barriers and Facilitators to Breast Cancer Screening Based on the Theoretical Domains Framework

Behavioral Sciences
Background: In the UK, breast cancer affects 1 in 8 women, accounting for 31% of cancers and 15% of cancer-related deaths in women. In 2023, London’s breast screening coverage was 56%, falling below the NHS target of 70%.
Sarah Huf, Ada Humphrey, Ara Darzi, Deborah Cunningham, Dominic King, Gaby Judah   +5 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Examining the Impact of Six Pro-Vaccination Messages on MMR Vaccine Hesitancy Among Mothers in Ukraine

European Journal of Health Communication (EJHC)
The Ukrainian government began delivering mandatory MMR vaccination letters to parents across the country in 2019. In this two-phase online RCT, we aimed to test the effectiveness of this national mandatory vaccination letter against five behavioural ...
Anastasiya Atif (Nurzhynska), Paul Chappell, Anna Sukhodolska, Jet G. Sanders   +3 more
doaj   +1 more source

Ethics in economic and management sciences: a researcher’s resource

South African Journal of Economic and Management Sciences, 2010
In an international research climate of increasingly demanding ethical review, based on a biomedical model, reflection on best practices in social, behavioural and economic science research is necessary.
Jaco Pienaar
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

The Collaborative Roots of Corruption? A Replication of Weisel & Shalvi (2015)

Collabra: Psychology, 2017
The present contribution highlights the importance of context while investigating dishonesty in collaborative settings.
Jeroen Wouda, Gijsbert Bijlstra, Willem E. Frankenhuis, Daniel H. J. Wigboldus   +3 more
doaj   +1 more source