Identification of an alternative ligand‐binding pocket in peroxisome proliferator‐activated receptor gamma and its correlated selective agonist for promoting beige adipocyte differentiation [PDF]
MedCommThe pharmacological activation of peroxisome proliferator‐activated receptor gamma (PPARγ) is a convenient and promising strategy for promoting beige adipocyte biogenesis to combat obesity‐related metabolic disorders.
Qiang Tian +8 more
doaj +3 more sources
A Method to Induce Brown/Beige Adipocyte Differentiation from Murine Preadipocytes [PDF]
Bio-Protocol, 2021 Adipocytes exhibit different morphological and functional characteristics, depending on their anatomical location, developmental origin, and stimulus. While white adipocytes tend to accumulate energy as triglycerides, brown and beige adipocytes tend to ...
Andréa Rocha +3 more
doaj +2 more sources
In vitro analyses of paracrine effects of murine classically activated macrophage on beige adipocyte metabolism [PDF]
STAR Protocols, 2022 Summary: The communication between macrophage and adipocyte plays a critical role in the initiation and development of metabolic inflammation, which is difficult to study in vivo.
Jingfei Yao, Dongmei Wu, Yifu Qiu
doaj +2 more sources
Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming [PDF]
eLife, 2023 The energy-burning capability of beige adipose tissue is a potential therapeutic tool for reducing obesity and metabolic disease, but this capacity is decreased by aging. Here, we evaluate the impact of aging on the profile and activity of adipocyte stem
Corey D Holman +8 more
doaj +2 more sources
eLife, 2017 Beige/brite adipocytes are induced within white adipose tissues (WAT) and, when activated, consume glucose and fatty acids to produce heat. Classically, two stimuli have been used to trigger a beiging response: cold temperatures and β3-adrenergic ...
Yuwei Jiang +2 more
doaj +2 more sources
Androgen Receptor is a Negative Regulator of PRDM16 in Beige Adipocyte [PDF]
Advanced Science, 2023 PRDM16 (PR domain containing protein 16) serves as a dominant activator of brown and beige adipocyte. However, mechanisms underlying the regulation of PRDM16 expression are incompletely understood.
Shiting Zhao +15 more
doaj +2 more sources
Reduced Beige Adipogenic Potential in Subcutaneous Adipocytes Derived from Obese Chinese Individuals
Diabetes, Metabolic Syndrome and Obesity, 2020 Han Li,1,* Lin Shen,2,* Lei Zhang,3 Bing Yan,3 Tao Sun,3 Feng Guo,3 Xiao Yin1 1Department of Endocrinology, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong 250013, People’s Republic of China; 2Shandong First Medical ...
Li H +6 more
doaj +2 more sources
Metabolic programming of a beige adipocyte phenotype by genistein. [PDF]
Mol Nutr Food Res, 2017 Scope Promoting the development of brown or beige adipose tissue may protect against obesity and related metabolic features, and potentially underlies protective effects of genistein in mice.
Aziz SA +5 more
europepmc +2 more sources
ESRRG and PERM1 Govern Mitochondrial Conversion in Brite/Beige Adipocyte Formation [PDF]
Frontiers in Endocrinology, 2020 When exposed to cold temperatures, mice increase their thermogenic capacity by an expansion of brown adipose tissue mass and the formation of brite/beige adipocytes in white adipose tissue depots.
Sebastian Müller +8 more
doaj +2 more sources
Circadian clock control of MRTF/SRF pathway suppresses beige adipocyte thermogenic recruitment. [PDF]
J Mol Cell Biol, 2023 Xiong X +5 more
europepmc +3 more sources