Results 11 to 20 of about 7,234 (170)

Adipocyte HIF2α functions as a thermostat via PKA Cα regulation in beige adipocytes

Nature Communications, 2022
Thermogenic adipocytes maintain body temperature in response to cold, but how this is tuned during cold and re-warming is unclear. Here, the authors show HIF2α inhibits beige adipocyte retention, regulating PKA catalysis to control dynamic adipocyte ...
Ji Seul Han, Yong Geun Jeon, Minsik Oh, Gung Lee, Hahn Nahmgoong, Sang Mun Han, Jeehye Choi, Ye Young Kim, Kyung Cheul Shin, Jiwon Kim, Kyuri Jo, Sung Sik Choe, Eun Jung Park, Sun Kim, Jae Bum Kim   +14 more
doaj   +3 more sources

Mouse strains to study cold-inducible beige progenitors and beige adipocyte formation and function [PDF]

Nature Communications, 2016
Beige adipocytes are formed in response to cold and thought to contribute to organismal energy homeostasis. Here, the authors study a range of conditional and inducible RFP-expressing Cre mouse strains and find that SMA-based lines are the most useful ...
Daniel C. Berry, Yuwei Jiang, Jonathan M. Graff   +2 more
doaj   +3 more sources

Functional and Genetic Characterization of Porcine Beige Adipocytes [PDF]

Cells, 2022
Beige adipocytes are a distinct type of fat cells with a thermogenic activity that have gained substantial attention as an alternative cellular anti-obesity target in humans. These cells may provide an alternative strategy for the genetic selection of pigs with reduced fat deposition.
Zhang, Lilan, Hu, Silu, Cao, Chunwei, Chen, Chuanhe, Liu, Jiali, Wang, Yu, Liu, Jianfeng, Zhao, Jianguo, Tao, Cong, Wang, Yanfang   +9 more
openaire   +3 more sources

Mitochondria in White, Brown, and Beige Adipocytes [PDF]

Stem Cells International, 2016
Mitochondria play a key role in energy metabolism in many tissues, including cardiac and skeletal muscle, brain, liver, and adipose tissue. Three types of adipose depots can be identified in mammals, commonly classified according to their colour appearance: the white (WAT), the brown (BAT), and the beige/brite/brown‐like (bAT) adipose tissues.
Miroslava Cedikova, Michaela Kripnerová, Jana Dvorakova, Pavel Pitule, Martina Grundmanova, Vaclav Babuska, Dana Mullerova, Jitka Kuncova   +7 more
openaire   +4 more sources

Aquaglyceroporins Are Differentially Expressed in Beige and White Adipocytes [PDF]

International Journal of Molecular Sciences, 2020
Browning of white adipocytes has been proposed as a powerful strategy to overcome metabolic complications, since brown adipocytes are more catabolic, expending energy as a heat form. However, the biological pathways involved in the browning process are still unclear.
Inês Vieira da Silva, Francisco Díaz-Sáez, António Zorzano, Anna Gumà, Marta Camps, Graça Soveral   +5 more
openaire   +3 more sources

Ceiling culture of human mature white adipocytes with a browning agent: A novel approach to induce transdifferentiation into beige adipocytes

Frontiers in Bioengineering and Biotechnology, 2022
Excess and dysfunctional adipose tissue plays an important role in metabolic diseases, including obesity, atherosclerosis and type 2 diabetes mellitus. In mammals, adipose tissue is categorized into two types: white and brown.
Yufei He, Zhuokai Liang, Jing Wang, Haojing Tang, Jian Li, Junrong Cai, Yunjun Liao   +6 more
doaj   +1 more source

Metabolic programming of a beige adipocyte phenotype by genistein. [PDF]

Mol Nutr Food Res, 2017
ScopePromoting the development of brown or beige adipose tissue may protect against obesity and related metabolic features, and potentially underlies protective effects of genistein in mice.Methods and resultsWe observed that application of genistein to 3T3‐L1 adipocytes changed the lipid distribution from large droplets to a multilocular distribution,
Aziz SA, Wakeling LA, Miwa S, Alberdi G, Hesketh JE, Ford D.   +5 more
europepmc   +5 more sources

Adaptive thermogenesis in adipocytes: Is beige the new brown? [PDF]

Genes & Development, 2013
One of the most promising areas in the therapeutics for metabolic diseases centers around activation of the pathways of energy expenditure. Brown adipose tissue is a particularly appealing target for increasing energy expenditure, given its amazing capacity to transform chemical energy into heat.
Wu, Jun, Cohen, Paul, Spiegelman, Bruce M.   +2 more
openaire   +4 more sources

A Smooth Muscle-Like Origin for Beige Adipocytes [PDF]

Cell Metabolism, 2014
Thermogenic UCP1-positive cells, which include brown and beige adipocytes, transform chemical energy into heat and increase whole-body energy expenditure. Using a ribosomal profiling approach, we present a comprehensive molecular description of brown and beige gene expression from multiple fat depots in vivo.
Long, Jonathan Z., Svensson, Katrin J., Tsai, Linus, Zeng, Xing, Roh, Hyun C., Kong, Xingxing, Rao, Rajesh R., Lou, Jesse, Lokurkar, Isha, Baur, Wendy, Castellot, John J., Rosen, Evan D., Spiegelman, Bruce M.   +12 more
openaire   +2 more sources

TET1 is a beige adipocyte-selective epigenetic suppressor of thermogenesis. [PDF]

Nat Commun, 2020
AbstractIt has been suggested that beige fat thermogenesis is tightly controlled by epigenetic regulators that sense environmental cues such as temperature. Here, we report that subcutaneous adipose expression of the DNA demethylase TET1 is suppressed by cold and other stimulators of beige adipocyte thermogenesis.
Damal Villivalam S, You D, Kim J, Lim HW, Xiao H, Zushin PH, Oguri Y, Amin P, Kang S.   +8 more
europepmc   +7 more sources