Results 101 to 110 of about 11,513 (248)

Functional Implications of DNA Methylation in Adipose Biology. [PDF]

, 2019
The twin epidemics of obesity and type 2 diabetes (T2D) are a serious health, social, and economic issue. The dysregulation of adipose tissue biology is central to the development of these two metabolic disorders, as adipose tissue plays a pivotal role ...
Kang, Sona, Ma, Xiang
core  

Pre- and postnatal adipose tissue development in farm animals: from stem cells to adipocyte physiology [PDF]

, 2016
To view supplementary material for this article, please visit http://dx.doi.org/10.1017/S1751731116000872Both white and brown adipose tissues are recognized to be differently involved in energy metabolism and are also able to secrete a variety of ...
Bonnet, Muriel, Gondret, Florence, Louveau, Isabelle, Perruchot, Marie-Hélène   +3 more
core   +3 more sources

Activation of estrogen receptor alpha induces beiging of adipocytes

Molecular Metabolism, 2018
Brown adipose tissue (BAT) and BAT-like adipose tissues, referred to as 'beige' adipose tissues uncouple respiration from ATP synthesis via uncoupling protein one (UCP-1). There is a sexual dimorphism with respect to beige and BAT tissues; pre-menopausal women have more BAT and are more sensitive to BAT activation than men or postmenopausal women.
Roberta S. Santos, Aaron P. Frank, Luciana A. Fátima, Biff F. Palmer, Orhan K. Öz, Deborah J. Clegg   +5 more
openaire   +4 more sources

Human Beige Adipocytes: Epiphenomenon or Drivers of Metabolic Improvements? [PDF]

Trends in Endocrinology & Metabolism, 2016
There is a lack of direct evidence that human brown or beige adipocytes improve whole-body energy homeostasis. In a recent study, Min et al. implanted proliferated human adipocyte progenitors from a 3D culture system in mice. Implants responded to adipogenic stimuli and had a beige-like phenotype upon induction that significantly improved systemic ...
Qiong A. Wang, Philipp E. Scherer
openaire   +3 more sources

Studying Brown Adipose Tissue in a Human in vitro Context

Frontiers in Endocrinology, 2020
New treatments for obesity and associated metabolic disease are increasingly warranted with the growth of the obesity pandemic. Brown adipose tissue (BAT) may represent a promising therapeutic target to treat obesity, as this tissue has been shown to ...
Isabella Samuelson, Isabella Samuelson, Antonio Vidal-Puig, Antonio Vidal-Puig   +3 more
doaj   +1 more source

Adipocyte browning and higher mitochondrial function in peri-adrenal but not subcutaneous fat in pheochromocytoma [PDF]

, 2016
Context: Patients with pheochromocytoma (pheo) show presence of multilocular adipocytes that express uncoupling protein (UCP) 1 within periadrenal (pADR) and omental (OME) fat depots. It has been hypothesized that this is due to adrenergic stimulation
Avital Harari, Betz, Bordicchia, Cannon, Chondronikola, Cypess, Cypess, Cypess, de Jong, Di Franco, Frontini, Giordano, Graeme R. Davies, Harold S. Sacks, Himms-Hagen, Hondares, Huang, Jason Y. Lin, Jespersen, Kajimura, Karen Reue, Kern, Laurent Vergnes, Leibel, Lidell, Masha J. Livhits, Michael E. Symonds, Michael W. Yeh, Nagano, Nedergaard, Patsouris, Petrovic, Plouin, Rogers, Sacks, Seale, Sharp, Shinoda, Sidossis, Stepniakowski, Strack, Svensson, Søndergaard, Ussar, van der Lans, van Marken Lichtenbelt, Virtanen, Waldén, Wu   +48 more
core   +1 more source

Induction of Beige-Like Adipocytes in 3T3-L1 Cells

Journal of Veterinary Medical Science, 2014
There are two types of brown adipocytes: classical brown adipocytes that form the brown fat depots and beige adipocytes that emerge in the white fat depots. Beige adipocytes have a low level of uncoupling protein 1 (Ucp1) expression in the basal state, but Ucp1 expression is increased in response to β adrenergic receptor activation.
ASANO, Hiroki, KANAMORI, Yohei, HIGURASHI, Satoshi, NARA, Takayuki, KATO, Ken, MATSUI, Tohru, FUNABA, Masayuki   +6 more
openaire   +4 more sources

Free Radicals in Health and Disease

MedComm, Volume 6, Issue 10, October 2025.
Free radicals have dual roles that can either selectively create oxidative damages to transformed cells in treating proliferative diseases such as cancers and some dermatological disorders or boost the antioxidant system in treating degenerative diseases such as neurodegenerative disorder, joint degeneration, and metabolic conditions.
Xiaofeng Dai, Zizheng Huang, Ruohan Lyu
wiley   +1 more source

Ontogeny and thermogenic role for sternal fat in female sheep [PDF]

, 2017
Brown adipose tissue acting through a unique uncoupling protein (UCP1) has a critical role in preventing hypothermia in new-born sheep but is then considered to rapidly disappear during postnatal life.
Albrecht, Alexander, Alexander, Atit, Bal, Barquissau, Basse, Belinda A. Henry, Bispham, Blessing, Blondin, Bloor, Cantile, Cao, Christian, Christodoulides, Clapham, Clarke, Clarke, Clarke, de Jong, Ellis, Elsen, Forner, Gburcik, Harms, Helen Budge, Henry, Henry, Henry, Henry, Horvath, Hotta, Hunt, Iain J. Clarke, John-Paul Fuller-Jackson, Kiskinis, Kooijman, Kurose, Lean, Lee, Lee, Loomis, Macotela, Mark Birtwistle, Mark Pope, Michael E. Symonds, Moldes, Møller, Nedergaard, Nedergaard, Nygaard, Ojha, Ootsuka, Petrovic, Pope, Rachael Loughnan, Ramayo-Caldas, Reham Alagal, Rosell, Rowland, Sacks, Sanchez-Gurmaches, Sanchez-Gurmaches, Scheele, Scotney, Seale, Sechen, Shan, Shinoda, Symonds, Symonds, Symonds, Symonds, Symonds, Symonds, Symonds, Timmons, van Marken Lichtenbelt, Vergnes, Virtanen, Viv Perry, Wellik, Xue, Yamamoto   +84 more
core   +2 more sources

Tissue‐Specific Effects of Dietary Protein on Cellular Senescence Are Mediated by Branched‐Chain Amino Acids

Aging Cell, Volume 24, Issue 10, October 2025.
Restriction of dietary BCAAs protects male mice from the metabolic consequences of both normal‐ and high‐protein diets. BCAA restriction also protects from hepatic cellular senescence in vivo and in vitro, especially in the context of mitochondrial stress. ABSTRACT Dietary protein is a key regulator of healthy aging in both mice and humans.
Mariah F. Calubag, Ismail Ademi, Isaac D. Grunow, Lucia E. Breuer, Reji Babygirija, Penelope Lialios, Sandra M. Le, Michelle M. Sonsalla, Julia A. Illiano, Bailey A. Knopf, Fan Xiao, Dennis Minton, Adam R. Konopka, David A. Harris, Dudley W. Lamming   +14 more
wiley   +1 more source