Results 111 to 120 of about 11,513 (248)

Mitochondrial fission is associated with UCP1 activity in human brite/beige adipocytes

Molecular Metabolism, 2018
Objective: Thermogenic adipocytes (i.e. brown or brite/beige adipocytes) are able to burn large amounts of lipids and carbohydrates as a result of highly active mitochondria and enhanced uncoupled respiration, due to UCP1 activity.
Didier F. Pisani, Valentin Barquissau, Jean-Claude Chambard, Diane Beuzelin, Rayane A. Ghandour, Maude Giroud, Aline Mairal, Sophie Pagnotta, Saverio Cinti, Dominique Langin, Ez-Zoubir Amri   +10 more
doaj   +1 more source

Genetically prolonged beige fat in male mice confers long-lasting metabolic health

Nature Communications, 2023
A potential therapeutic target to curb obesity and diabetes is thermogenic beige adipocytes. However, beige adipocytes quickly transition into white adipocytes upon removing stimuli.
Ruifan Wu, Jooman Park, Yanyu Qian, Zuoxiao Shi, Ruoci Hu, Yexian Yuan, Shaolei Xiong, Zilai Wang, Gege Yan, Sang-Ging Ong, Qing Song, Zhenyuan Song, Abeer M. Mahmoud, Pingwen Xu, Congcong He, Robert W. Arpke, Michael Kyba, Gang Shu, Qingyan Jiang, Yuwei Jiang   +19 more
doaj   +1 more source

Mitochondrial lipoylation integrates age-associated decline in brown fat thermogenesis. [PDF]

, 2019
Thermogenesis in brown adipose tissue (BAT) declines with age; however, what regulates this process remains poorly understood. Here, we identify mitochondria lipoylation as a previously unappreciated molecular hallmark of aged BAT in mice.
Chang, Chih-Hsiang, Chang, Hsin-Yi, Ikeda, Kenji, Ishihama, Yasushi, Jun, Heejin, Kajimura, Shingo, Oguri, Yasuo, Tajima, Kazuki, Wu, Jun, Yoneshiro, Takeshi   +9 more
core  

Perirenal Fat in Disease Progression: From Inflammatory Mediator to Therapeutic Target

International Journal of Urology, Volume 32, Issue 10, Page 1314-1320, October 2025.
ABSTRACT Perirenal fat (PRF), the adipose tissue that encases the kidneys, has long been considered a passive energy reservoir and mechanical buffer. However, emerging evidence has identified PRF as a biologically active visceral fat depot that secretes adipocytokines, inflammatory mediators, and other bioactive molecules, and thereby contributes to ...
Eiji Kashiwagi
wiley   +1 more source

Brown and Beige Fat: Therapeutic Potential in Obesity [PDF]

, 2014
BACKGROUND: The epidemic of obesity and type 2 diabetes presents a serious challenge to scientific and biomedical communities worldwide. There has been an upsurge of interest in the adipocyte coincident with the onset of the obesity epidemic and the ...
Meiliana, A. (Anna), Wijaya, A. (Andi)
core  

Exercise-induced ‘browning’ of adipose tissues [PDF]

, 2017
Global rates of obesity continue to rise and are necessarily the consequence of a long-term imbalance between energy intake and energy expenditure. This is the result of an expansion of adipose tissue due to both the hypertrophy of existing adipocytes ...
Albrecht, Antonopoulos, Arner, Barreau, Berry, Bloor, Bogardus, Bordbar, Bostrom, Cannon, Carriere, Chaudhuri, Coelho, Craig Sale, Cypess, de Jong, De Matteis, Despres, Despres, Despres, Disanzo, DiSpirito, During, Emre, Fischer, Follenius, Fromme, Gagnon, Giralt, Haczeyni, Helen Budge, Hetzler, James Betts, Jespersen, Joyner, Kammoun, Kazak, Knudsen, Larue-Achagiotis, Liu, Long, M, Ma, Magkos, Maloney, Margaritis, Mark Pope, Marker, Matsushita, Michael E. Symonds, Nakhuda, Nielsen, Nozu, Oelkrug, Ostrowski, Palmer, Patsouris, Peppler, Peter Aldiss, Powers, Rao, Razzoli, Robciuc, Ronn, Sacks, Sanchez-Gurmaches, Scheele, Schreiber, Scott, Sengenes, Sepa-Kishi, Shabalina, Shimizu, Shin, Sidossis, Singhal, Stanford, Takx, Thomas, Thompson, Trayhurn, Tsiloulis, Tsoli, van Marken Lichtenbelt, Vergnes, Vieira, Virtanen, Vosselman, Woods, Wu, Wu, Yamashita, Yoneshiro   +92 more
core   +3 more sources

From fibro/adipogenic progenitors to adipocytes: Understanding adipogenesis in muscle degeneration for disease modulation

The Journal of Physiology, Volume 603, Issue 19, Page 5273-5297, October 1, 2025.
Abstract figure legend Fibro/adipogenic progenitors (FAPs) are cells resident in the muscle (skeletal and cardiac) niche. FAPs are active participants in the process of muscle degeneration in cardiovascular and neuromuscular diseases. Here, the accumulation of fatty and fibrous tissue is a hallmark.
Elisa Villalobos, Priyanka Mehra, Jordi Diaz‐Manera   +2 more
wiley   +1 more source

Development of an adipocyte differentiation protocol using 3T3-L1 cells for the investigation of the browning process: identification of the PPAR-γ agonist rosiglitazone as a browning reference drug

Frontiers in Pharmacology
BackgroundObesity is a metabolic disease that is characterized by an excessive accumulation of adipose tissue (AT) and is often associated with other pathologies.
Lorenzo Flori, Giulia Galgani, Giorgia Bray, Chiara Ippolito, Cristina Segnani, Carolina Pellegrini, Valentina Citi, Valentina Citi, Nunzia Bernardini, Nunzia Bernardini, Alma Martelli, Alma Martelli, Alma Martelli, Vincenzo Calderone, Vincenzo Calderone, Vincenzo Calderone   +15 more
doaj   +1 more source

γ-synuclein is a novel player in the control of body lipid metabolism [PDF]

, 2013
Peer reviewedPublisher ...
Buchman, Vladimir L, Millership, Steven, Ninkina, Natalia, Rochford, Justin J   +3 more
core   +1 more source

Molecular Regulation of Thermogenic Mechanisms in Beige Adipocytes

International Journal of Molecular Sciences
Adipose tissue is conventionally recognized as a metabolic organ responsible for storing energy. However, a proportion of adipose tissue also functions as a thermogenic organ, contributing to the inhibition of weight gain and prevention of metabolic diseases.
Siqi Yang, Yingke Liu, Xiaoxu Wu, Rongru Zhu, Yuanlu Sun, Shuoya Zou, Dongjie Zhang, Xiuqin Yang   +7 more
openaire   +2 more sources