Fighting obesity by targeting factors regulating beige adipocytes. [PDF]
Current Opinion in Clinical Nutrition & Metabolic Care, 2018 Purpose of reviewThe current review provides an update on secreted factors and mechanisms that promote a thermogenic program in beige adipocytes, and their potential roles as therapeutic targets to fight obesity.Recent findingsWe outline recent studies ...
Koliwad, Suneil K +2 more
core +6 more sources
Lactate Conversion by Lactate Dehydrogenase B Is Involved in Beige Adipocyte Differentiation and Thermogenesis in Mice. [PDF]
Nutrients, 2023 Guo B +11 more
europepmc +3 more sources
Adipocyte HIF2α functions as a thermostat via PKA Cα regulation in beige adipocytes
Nature Communications, 2022 Thermogenic adipocytes maintain body temperature in response to cold, but how this is tuned during cold and re-warming is unclear. Here, the authors show HIF2α inhibits beige adipocyte retention, regulating PKA catalysis to control dynamic adipocyte ...
Ji Seul Han +14 more
doaj +3 more sources
Functional and Genetic Characterization of Porcine Beige Adipocytes [PDF]
Cells, 2022 Beige adipocytes are a distinct type of fat cells with a thermogenic activity that have gained substantial attention as an alternative cellular anti-obesity target in humans. These cells may provide an alternative strategy for the genetic selection of pigs with reduced fat deposition.
Lilan Zhang +9 more
openalex +5 more sources
Decoding temporal thermogenesis: coregulator selectivity and transcriptional control in brown and beige adipocytes [PDF]
AdipocyteIn mammals, brown adipose tissue (BAT) and beige adipocytes in white adipose tissue (WAT) play pivotal roles in maintaining body temperature and energy metabolism.
Yong Geun Jeon, Sun Won Kim, Jae Bum Kim
doaj +2 more sources
Optogenetics Sheds Light on Brown and Beige Adipocytes [PDF]
Journal of Cellular Signaling, 2023 Excessive food intake leads to lipid accumulation in white adipose tissue, triggering inflammation, cellular stress, insulin resistance, and metabolic syndrome. In contrast, the dynamic energy expenditure and heat generation of brown and beige adipose tissue, driven by specialized mitochondria, render it an appealing candidate for therapeutic ...
Aaron C. Brown
openalex +3 more sources
EBF2 promotes the recruitment of beige adipocytes in white adipose tissue
Molecular Metabolism, 2016 Objective: The induction of beige/brite adipose cells in white adipose tissue (WAT) is associated with protection against high fat diet-induced obesity and insulin resistance in animals.
Rachel R. Stine +6 more
doaj +4 more sources
Neural control of white, beige and brown adipocytes [PDF]
International Journal of Obesity Supplements, 2015 Reports of brown-like adipocytes in traditionally white adipose tissue (WAT) depots occurred ~30 years ago, but interest in white adipocyte 'browning' only has gained attention more recently. We integrate some of what is known about the sympathetic nervous system (SNS) innervation of WAT and brown adipose tissue (BAT) with the few studies focusing on ...
Timothy J. Bartness, Vitaly Ryu
openalex +4 more sources
Mouse strains to study cold-inducible beige progenitors and beige adipocyte formation and function [PDF]
Nature Communications, 2016 Beige adipocytes are formed in response to cold and thought to contribute to organismal energy homeostasis. Here, the authors study a range of conditional and inducible RFP-expressing Cre mouse strains and find that SMA-based lines are the most useful ...
Daniel C. Berry +2 more
doaj +4 more sources
Bola3 Regulates Beige Adipocyte Thermogenesis via Maintaining Mitochondrial Homeostasis and Lipolysis. [PDF]
Front Endocrinol (Lausanne), 2020 Bai N +12 more
europepmc +3 more sources