Results 41 to 50 of about 11,954 (253)

Thermal stress induces glycolytic beige fat formation via a myogenic state. [PDF]

, 2019
Environmental cues profoundly affect cellular plasticity in multicellular organisms. For instance, exercise promotes a glycolytic-to-oxidative fibre-type switch in skeletal muscle, and cold acclimation induces beige adipocyte biogenesis in adipose tissue.
A Jaworski, AA Lans van der, Andrew Brack, Annarita Scaramozza, C Trapnell, Carlos Henrique Sponton, DC Berry, ES Bachman, H Ohno, J Nedergaard, J Sanchez-Gurmaches, J Wu, JR Arch, JZ Long, K Ikeda, K Nishijo, K Shinoda, Kazuki Tajima, Kenji Ikeda, Kosaku Shinoda, Kyeongkyu Kim, L Kazak, L Vishvanath, L Ye, LZ Sharp, M Razzoli, ME Lidell, MJ Hanssen, ML Gantner, MS Rodeheffer, P Cohen, P Seale, Qiang Wang, S Collins, S Heinz, S Jung, S Kajimura, S Tripathi, Shingo Kajimura, T Buch, T Yoneshiro, Takeshi Yoneshiro, VK Mootha, Y Hasegawa, YH Lee, YH Tseng, Yong Chen, Zachary Brown, ZF Yang   +48 more
core   +2 more sources

A Smooth Muscle-Like Origin for Beige Adipocytes [PDF]

Cell Metabolism, 2014
Thermogenic UCP1-positive cells, which include brown and beige adipocytes, transform chemical energy into heat and increase whole-body energy expenditure. Using a ribosomal profiling approach, we present a comprehensive molecular description of brown and beige gene expression from multiple fat depots in vivo.
Long, Jonathan Z., Svensson, Katrin J., Tsai, Linus, Zeng, Xing, Roh, Hyun C., Kong, Xingxing, Rao, Rajesh R., Lou, Jesse, Lokurkar, Isha, Baur, Wendy, Castellot, John J., Rosen, Evan D., Spiegelman, Bruce M.   +12 more
openaire   +2 more sources

Adipose mTORC1 Suppresses Prostaglandin Signaling and Beige Adipogenesis via the CRTC2-COX-2 Pathway

Cell Reports, 2018
Summary: Beige adipocytes are present in white adipose tissue (WAT) and have thermogenic capacity to orchestrate substantial energy metabolism and counteract obesity.
Xing Zhang, Yan Luo, Chunqing Wang, Xiaofeng Ding, Xin Yang, Dandan Wu, Floyd Silva, Zijiang Yang, Qin Zhou, Lu Wang, Xiaoqing Wang, Jianlin Zhou, Nathan Boyd, Michael Spafford, Mark Burge, Xuexian O. Yang, Meilian Liu   +16 more
doaj   +1 more source

The corticotrophin-releasing factor/urocortin system regulates white fat browning in mice through paracrine mechanisms [PDF]

, 2015
Objectives: The corticotrophin-releasing factor (CRF)/urocortin system is expressed in the adipose tissue of mammals, but its functional role in this tissue remains unknown.
Clark, S., Contarino, A., Cota, D., Diz-Chaves, Y., Fanelli, F., Grammatopoulos, Dimitris, Lehnert, Hendrik, Lu, B., Markovic, Danijela, Penicaud, L., Tabarin, A.   +10 more
core   +3 more sources

Beige Fat, Adaptive Thermogenesis, and Its Regulation by Exercise and Thyroid Hormone

Biology, 2019
While it is now understood that the proper expansion of adipose tissue is critically important for metabolic homeostasis, it is also appreciated that adipose tissues perform far more functions than simply maintaining energy balance.
Kevin J. Phillips
doaj   +1 more source

PON2 Deficiency Leads to Increased Susceptibility to Diet-Induced Obesity. [PDF]

, 2019
(1) Background: Paraoxonase 2 (PON2) is a ubiquitously expressed protein localized to endoplasmic reticulum and mitochondria. Previous studies have shown that PON2 exhibits anti-oxidant and anti-inflammatory functions, and PON2-deficient (PON2-def) mice ...
Fogelman, Alan M, Lusis, Aldons J, Meng, Yonghong, Reddy, Srinivasa T, Reue, Karen, Sallam, Tamer, Shih, Diana M, Shu, Michelle L, Tontonoz, Peter, Vergnes, Laurent   +9 more
core   +1 more source

ASK1 signalling regulates brown and beige adipocyte function [PDF]

Nature Communications, 2016
AbstractRecent studies suggest that adult humans have active brown or beige adipocytes, the activation of which might be a therapeutic strategy for the treatment of diverse metabolic diseases. Here we show that the protein kinase ASK1 regulates brown and beige adipocytes function.
Kazuki Hattori, Isao Naguro, Kohki Okabe, Takashi Funatsu, Shotaro Furutani, Kohsuke Takeda, Hidenori Ichijo   +6 more
openaire   +3 more sources

Adipocyte-specific Hypoxia-inducible gene 2 promotes fat deposition and diet-induced insulin resistance

Molecular Metabolism, 2016
Objective: Adipose tissue relies on lipid droplet (LD) proteins in its role as a lipid-storing endocrine organ that controls whole body metabolism.
Marina T. DiStefano, Rachel J. Roth Flach, Ozlem Senol-Cosar, Laura V. Danai, Joseph V. Virbasius, Sarah M. Nicoloro, Juerg Straubhaar, Sezin Dagdeviren, Martin Wabitsch, Olga T. Gupta, Jason K. Kim, Michael P. Czech   +11 more
doaj   +1 more source

Glucocorticoid Receptor and Adipocyte Biology. [PDF]

, 2018
Glucocorticoids are steroid hormones that play a key role in metabolic adaptations during stress, such as fasting and starvation, in order to maintain plasma glucose levels.
Harris, Charles A, Lee, Rebecca A, Wang, Jen-Chywan   +2 more
core   +2 more sources

Sympathetic nerve innervation is required for beigeing in white fat

Physiological Reports, 2019
It is increasingly recognized that activation of beige adipocyte thermogenesis by pharmacological or genetic approaches increases energy expenditure and alleviates obesity.
Qiang Cao, Jia Jing, Xin Cui, Hang Shi, Bingzhong Xue   +4 more
doaj   +1 more source