Results 71 to 80 of about 11,513 (248)
iMetaOmics, EarlyView.Prmt5AKO downregulates genes related to fatty acid transport and triacylglycerol synthesis, while upregulating genes involved in glucose transport and cholesterol biogenesis. These changes cause alternation in lipid composition and metabolic phenotypes of Prmt5AKO mice. Abstract The adipose tissue (AT) is a main regulator of systemic energy homeostasis,
Xiyue Chen +7 more
wiley +1 more source
PCB126 blocks the thermogenic beiging response of adipocytes
Environmental Science and Pollution Research, 2019 Subcutaneous white adipose tissue is capable of becoming thermogenic in a process that is referred to as "beiging." Beiging is associated with activation of the uncoupling protein, UCP1, and is known to be important for preventing adipose hypertrophy and development of insulin resistance.
Francoise A. Gourronc +3 more
openaire +3 more sources
Development of NASH in Obese Mice is Confounded by Adipose Tissue Increase in Inflammatory NOV and Oxidative Stress [PDF]
, 2018 Aim. Nonalcoholic steatohepatitis (NASH) is the consequence of insulin resistance, fatty acid accumulation, oxidative stress, and lipotoxicity.We hypothesize that an increase in the inflammatory adipokine NOV decreases antioxidant Heme Oxygenase 1 (HO- 1)
Abraham, Nader G. +13 more
core +1 more source
Small Science, EarlyView.Current weight‐loss medications inevitably cause adverse effects such as depression or muscle loss. The developed GIP/ICG@P/R8 NPs specifically promoted energy expenditure by inducing browning, lipolysis and apoptosis of WAT in vitro and in vivo. The results showed a 9.23% weight reduction after 14 days, enhanced insulin sensitivity, improved fatty ...
Ting Xie +11 more
wiley +1 more source
Formation of thermogenic adipocytes: What we have learned from pigs
Fundamental Research, 2021 Thermogenic adipocytes, including brown and beige adipocytes, are capable of dissipating energy via heat production in response to external stimuli, such as cold exposure and exercise.
Jianguo Zhao +4 more
doaj +1 more source
Weight Loss‐Associated Remodeling of Adipose Tissue Immunometabolism
Obesity Reviews, EarlyView.ABSTRACT Obesity is a multifactorial condition characterized by excessive adiposity and systemic chronic low‐grade inflammation. Recent literature reflects a growing appreciation for the complex interplay between metabolism and the immune system in the pathogenesis of obesity‐related health conditions.
Paulo José Basso +5 more
wiley +1 more source
Differential actions of PPAR-α and PPAR-β/δ on beige adipocyte formation: A study in the subcutaneous white adipose tissue of obese male mice. [PDF]
PLoS ONE, 2018 Obesity compromises adipocyte physiology. PPARs are essential to adipocyte plasticity, but its isolated role in the browning phenomenon is not clear. This study aimed to examine whether activation of PPAR-α or PPAR-β/δ could induce beige cell depots in ...
Tamiris Lima Rachid +5 more
doaj +1 more source
Notch signaling regulates adipose browning and energy metabolism [PDF]
, 2014 Beige adipocytes in white adipose tissue (WAT) are similar to classical brown adipocytes in that they can burn lipids to produce heat. Thus, an increase in beige adipocyte content in WAT browning would raise energy expenditure and reduce adiposity.
Bi, Pengpeng +10 more
core +2 more sources
Experimental Physiology, EarlyView.Abstract The global prevalence of obesity and related metabolic disorders has spurred interdisciplinary research to develop new intervention strategies. Current research is increasingly focusing on the exercise‐induced browning of white adipose tissue and the mechanisms by which it improves energy metabolism.
Yuhui Su +4 more
wiley +1 more source
iScience, 2022 Summary: Receptor-interacting protein kinase-3 (RIPK3) and mixed lineage kinase domain-like (MLKL) proteins are key regulators of necroptosis, a highly pro-inflammatory mode of cell death, which has been involved in various human diseases.
Julie Magusto +13 more
doaj +1 more source