Results 91 to 100 of about 38,129 (248)

IRX3 Overexpression Enhances Ucp1 Expression In Vivo

Frontiers in Endocrinology, 2021
ObjectiveThe Iroquois homeobox 3 (IRX3) gene was recently reported to be a functional downstream target of a common polymorphism in the FTO gene, which encodes an obesity-associated protein; however, the role of IRX3 in energy expenditure remains unclear.
Zhiyin Zhang, Zhiyin Zhang, Qihan Wu, Qihan Wu, Yang He, Yang He, Peng Lu, Peng Lu, Danjie Li, Danjie Li, Minglan Yang, Minglan Yang, Weiqiong Gu, Weiqiong Gu, Ruixin Liu, Ruixin Liu, Jie Hong, Jie Hong, Jiqiu Wang, Jiqiu Wang   +19 more
doaj   +1 more source

A Synergistic Antiobesity Effect by a Combination of Capsinoids and Cold Temperature Through Promoting Beige Adipocyte Biogenesis. [PDF]

, 2016
Beige adipocytes emerge postnatally within the white adipose tissue in response to certain environmental cues, such as chronic cold exposure. Because of its highly recruitable nature and relevance to adult humans, beige adipocytes have gained much ...
Bannai, Makoto, Kajimura, Shingo, Nogusa, Yoshihito, Ohyama, Kana, Shinoda, Kosaku, Suzuki, Katsuya   +5 more
core   +2 more sources

CDK6 inhibits white to beige fat transition by suppressing RUNX1. [PDF]

Nat Commun, 2018
AbstractWhereas white adipose tissue depots contribute to the development of metabolic diseases, brown and beige adipose tissue has beneficial metabolic effects. Here we show that CDK6 regulates beige adipocyte formation. We demonstrate that mice lacking the CDK6 protein or its kinase domain (K43M) exhibit significant increases beige cell formation ...
Hou X, Zhang Y, Li W, Hu AJ, Luo C, Zhou W, Hu JK, Daniele SG, Wang J, Sheng J, Fan Y, Greenberg AS, Farmer SR, Hu MG.   +13 more
europepmc   +7 more sources

Adipocyte Liver Kinase b1 Suppresses Beige Adipocyte Renaissance Through Class IIa Histone Deacetylase 4. [PDF]

, 2017
Uncoupling protein 1+ beige adipocytes are dynamically regulated by environment in rodents and humans; cold induces formation of beige adipocytes, whereas warm temperature and nutrient excess lead to their disappearance. Beige adipocytes can form through
Chawla, Ajay, Huang, Wendong, Paulo, Esther, Wang, Biao, Wang, Yangmeng, Wu, Dongmei, Wu, Yixuan   +6 more
core   +1 more source

T2T Genomes Unveil Centromere Architecture and Adaptive Divergence in Large Yellow Croaker (Larimichthys crocea)

Advanced Science, EarlyView.
This study presents telomere‐to‐telomere genome assemblies for two populations of Larimichthys crocea. We identified centromere‐specific tandem repeats invaded by LTR/ERV1 retrotransposons, unique 5S rRNA enrichment patterns, and population‐specific structural variants. Comparative genomic analyses further reveal distinct adaptive mechanisms in the MYD
Yu Cui, Yingbo Yuan, Bi Wang, Baolan Wu, Mingyi Cai, Ming Fang, Weiliang Shen, Xiongfei Wu, Fang Han, Zhiyong Wang   +9 more
wiley   +1 more source

Nonalcoholic Fatty Liver Disease Exacerbates the Advancement of Renal Fibrosis by Modulating Renal CCR2+PIRB+ Macrophages Through the ANGPTL8/PIRB/ALOX5AP Axis

Advanced Science, EarlyView.
The ANGPTL8/PIRB/ALOX5AP axis mediates liver‐kidney crosstalk. Hepatocytes secrete ANGPTL8, which binds to CCR2+PIRB+ macrophages in the kidneys, affecting the expression of ALOX5AP and enhancing the activation of these macrophages. Activated cells produce TGF‐β, IL‐6, and IL‐23, driving Th17 activation and promote the formation of myofibroblasts ...
Shuqi Wei, Diwen Shou, Siyuan Huang, Yingsi Wang, Quanzhen Liu, Jinfa Liu, Xiaoyu Lv, Yuyi Zeng, Liting Wei, Han Lin, Jiechuan Chen, Yangxiao Chen, Haoyu Zhong, Yanqing Zhou, Wen Ma, Li Wang, Guojun Qian, Jing Guo, Donglin Sun   +18 more
wiley   +1 more source

Reversing Pdgfrβ signaling restores metabolically active beige adipocytes by alleviating ILC2 suppression in aged and obese mice

Molecular Metabolism
Objective: Platelet Derived Growth Factor Receptor Beta (Pdgfrβ) suppresses the formation of cold temperature-induced beige adipocytes in aged mammals.
Abigail M. Benvie, Daniel C. Berry
doaj   +1 more source

Control of Adipose Cell Browning and Its Therapeutic Potential

Metabolites, 2020
Adipose tissue is the largest endocrine organ in humans and has an important influence on many physiological processes throughout life. An increasing number of studies have described the different phenotypic characteristics of fat cells in adults ...
Fernando Lizcano, Felipe Arroyave
doaj   +1 more source

NRF2‐REGγ‐ACADM/KLF15 Signaling Pathway Regulates the Browning of White Adipose Tissue to Modulate Obesity

Advanced Science, EarlyView.
This study identifies that REGγ is elevated in obese adipose tissue. REGγ modulates WAT browning via ubiquitin‐independent ACADM/KLF15–UCP1 degradation. Overactivation of the NRF2–REGγ axis facilitates adipose tissue function to cause obesity. Inhibition of REGγ in the iWAT alleviates HFD‐induced obesity.
Hui Chen, Qiujing Guan, Shuangming Gong, Yingying Du, Zhidan Zhang, Yan Liu, Lei Zhou, Lin Liu, Baoquan Xin, Yilan Guo, Hui Zhang, Ziyang Zhou, Tongchao Pei, Guohong Yu, Sokun Yin, Lei Li   +15 more
wiley   +1 more source

Cold-Inducible SIRT6 Regulates Thermogenesis of Brown and Beige Fat [PDF]

Cell Reports, 2017
Promoting development and function of brown and beige fat may reduce obesity. Here, we show that fat SIRT6 expression is markedly induced by cold exposure and a β-adrenergic agonist. Deletion of SIRT6 in adipose tissue impairs the thermogenic function of brown adipocytes, causing a morphological "whitening" of brown fat, reduced oxygen (O2) consumption,
Lu Yao, Fude Fang, Wanzhu Jin, Guoqing Liu, Xiaoying Yang, Qi Chen, Xiaona Cui, Yongsheng Chang, Jun Zhang   +8 more
openaire   +4 more sources