Results 101 to 110 of about 10,902 (169)

Human Islet miR‐199a‐5p and miR‐214‐3p Associate With Donor Age, BMI, and Sex and Mediate Cellular Aging in Islet‐Derived Cells

Acta Physiologica, Volume 242, Issue 8, August 2026.
ABSTRACT Objectives Human islets are widely researched to understand pathophysiological mechanisms leading to diabetes. Sex, age, and body mass index (BMI) are key donor traits influencing islet function, which is also regulated by an intricate network of microRNAs.
Wilson K. M. Wong, Isabelle El‐Azzi, Aditya Nachanekar, Ehsan Alvandi, Nhan Ho Trong Pham, Hrishikesh P. Hardikar, Mya Polkamp, Vijit Saini, Feifei Cheng, Guozhi Jiang, Anja E. Sørensen, Yi Vee Chew, Helen E. Thomas, Thomas Loudovaris, Ronald C. W. Ma, Wayne J. Hawthorne, Louise T. Dalgaard, Mugdha V. Joglekar, Anandwardhan A. Hardikar   +18 more
wiley   +1 more source

EPAC1 enhances brown fat growth and beige adipogenesis

Nature Cell Biology
AbstractBrown adipose tissue (BAT) is a central thermogenic organ that enhances energy expenditure and cardiometabolic health. However, regulators that specifically increase the number of thermogenic adipocytes are still an unmet need. Here, we show that the cAMP-binding protein EPAC1 is a central regulator of adaptive BAT growth.
Reverte-Salisa, Laia, Siddig, Sana, Hildebrand, Staffan, Yao, Xi, Zurkovic, Jelena, Jaeckstein, Michelle, Heeren, Joerg, Lezoualc'H, Frank, Krahmer, Natalie, Pfeifer, Alexander   +9 more
openaire   +4 more sources

Human IDO2 exhibits unique binding affinities distinct to those of human IDO1

The FEBS Journal, Volume 293, Issue 15, Page 4533-4553, August 2026.
Although indoleamine 2,3‐dioxygenase 2 (IDO2) is highly homologous to IDO1, it displays markedly lower catalytic activity. We found that IDO2 binds L‐tryptophan (L‐Trp) in a flipped orientation stabilized by the IDO2‐specific residue His143. Replacement of His143 with the IDO1‐equivalent tyrosine restored an IDO1‐like binding mode and increased ...
Shunsuke Nogi, Ayumu Takahashi, So Murakami, Nami Adachi, Tina Fujimoto, Yohta Fukuda, Taku Yamashita, Tsuyoshi Inoue, Hirofumi Tsujino   +8 more
wiley   +1 more source

Effects of Label and Short Video Communication on Symbolic Perceptions of a Cereal Bar With a Low‐Familiarity Ingredient

Journal of Sensory Studies, Volume 41, Issue 4, August 2026.
ABSTRACT This study examined how two communication modalities, a regulatory‐style product label and a short promotional vídeo, shape symbolic perceptions, social representations, and consumer evaluations of a cereal bar formulated with Jerusalem artichoke, a low‐familiarity functional ingredient.
Anderson Antonio Neto da Silva, Jéssica Ferreira Rodrigues, João de Deus Souza Carneiro, Isabella de Cássia Batista, Samara Mafra Maroum, Rita de Cássia Vieira, Giovana Paula da Silva, Letícia Naomy Maria Landim Etto, Guilherme Silva Pianca, Beatriz Asevedo Correa da Silva, Luísa Silva Ribeiro, Joaquim Adelino de Azevedo Filho   +11 more
wiley   +1 more source

Toll Like Receptor 4: A Potential Link Between Obesity and Metabolic Diseases

Obesity Reviews, Volume 27, Issue 8, August 2026.
ABSTRACT Epidemiological evidence shows that obesity increases the risk of developing metabolic diseases. Nevertheless, the mechanisms behind this connection remain underappreciated. The substantial impact of these disorders on global health has led to extensive research efforts aimed at identifying the pathophysiological links between them.
Ghadeer Alhamar, Joanna Razafiarison, Fawaz Alzaid, Fahd Al‐Mulla, Rasheed Ahmad   +4 more
wiley   +1 more source

Effects of Glucagon‐Like Peptide‐1 Receptor Agonists (Mono and Combination Therapy) on Energy Expenditure: A Scoping Review

Obesity Reviews, Volume 27, Issue 8, August 2026.
ABSTRACT Introduction Weight loss results in reduced energy expenditure (EE) due to body composition alterations (e.g., fat‐free mass and fat mass losses) and mass‐independent adaptations in EE (e.g., hormones). Glucagon‐like peptide‐1 receptor agonists (GLP‐1RA) are indicated for obesity management; however, their effects on EE remain unclear ...
Flavio T. Vieira, ZhiDi Deng, Manfred J. Muller, Giovanna G. L. Bergamasco, Sarah Cawsey, Melania Manco, Steven B. Heymsfield, Carla M. Prado, Andrea M. Haqq   +8 more
wiley   +1 more source

Rutin Maintains the Thermogenic Phenotype of Beige Adipocytes and Concomitantly Suppresses Mitophagy Against Obesity in HFD Mice

Metabolites
Background: The browning of white adipose tissue for thermogenesis is an effective strategy for combating obesity. The formation of beige adipocytes is reversible, making their maintenance a key therapeutic target.
Jianmei Li, Kexin Li, Shengnan Li, Jingxun Cui, Shuangying Zhou, Huiwen Wu   +5 more
doaj   +1 more source

Intraperitoneal administration of follistatin promotes adipocyte browning in high-fat diet-induced obese mice.

PLoS ONE, 2019
With rapid economic development, the prevalence of obesity has increased remarkably worldwide. Obesity can induce a variety of metabolic diseases, such as atherosclerosis, diabetes, hypertension and coronary heart disease, which significantly endanger ...
Haoyu Li, Chuanhai Zhang, Junyu Liu, Wenya Xie, Wentao Xu, Fei Liang, Kunlun Huang, Xiaoyun He   +7 more
doaj   +1 more source

Long‐term adverse cardiovascular changes induced by cocoa shell extract administration through lactation in fetal undernourished and control rats

Experimental Physiology, Volume 111, Issue 8, Page 3667-3683, 1 August 2026.
Abstract Cocoa shell extract (CSE; rich in antioxidant compounds) administered to adult hypertensive rats exposed to fetal undernutrition (MUN) reduces blood pressure, improving cardiovascular alterations. We aimed to explore lactation as a reprogramming window, evaluating the long‐term effects of CSE supplementation during this period. MUN and control
Santiago Ruvira, Pilar Rodríguez‐Rodríguez, Metee Iampanichakul, Begoña Quintana‐Villamandos, Dolores Morales, David Ramiro‐Cortijo, Silvia M. Arribas   +6 more
wiley   +1 more source

Genetically prolonged beige fat in male mice confers long-lasting metabolic health. [PDF]

Nat Commun, 2023
Wu R, Park J, Qian Y, Shi Z, Hu R, Yuan Y, Xiong S, Wang Z, Yan G, Ong SG, Song Q, Song Z, Mahmoud AM, Xu P, He C, Arpke RW, Kyba M, Shu G, Jiang Q, Jiang Y.   +19 more
europepmc   +1 more source