Results 91 to 100 of about 10,902 (169)

Understanding the Molecular Processes of Obesity and the Anti‐Obesity Properties of Bioactive Substances Found in Tea

open access: yesPhytochemicals in Food and Medicine, Volume 1, Issue 3, September 2026.
ABSTRACT Obesity, a severe worldwide health concern, is characterized as an excessive deposit of fat in the human body. It has various ramifications that endanger human health and increase the financial expense. Obesity raises the risk of several illnesses, notably cardiovascular disease, NALFD, and diabetes, and has been associated with shorter ...
Sakhawat Riaz   +6 more
wiley   +1 more source

A Four‐Week Treatment With Dapagliflozin Is Associated With a Reduction in Insulin‐Stimulated Renal Cortical Glucose Uptake: A Post Hoc Analysis From a Pilot Study

open access: yesDiabetes, Obesity and Metabolism, Volume 28, Issue 9, Page 8329-8336, September 2026.
ABSTRACT Introduction and Objective Treatment with sodium‐glucose cotransporter‐2 inhibitors (SGLT‐2i) reduces the risk of both cardiovascular and renal outcomes in type 2 diabetes (T2D). The specific mechanism by which this happens has not yet been clarified.
Shawn Gugliandolo   +18 more
wiley   +1 more source

Systems‐Level Plant Responses Reveal Pseudomonas‐Mediated Growth Promotion in Brachypodium Under Nitrogen Limitation

open access: yesPlant, Cell &Environment, Volume 49, Issue 9, Page 6396-6412, September 2026.
ABSTRACT Plant growth–promoting bacteria can enhance plant performance under nutrient limitation, yet the underlying plant molecular responses remain incompletely resolved. We investigated growth promotion by Pseudomonas koreensis in Brachypodium distachyon under contrasting nitrogen (N) regimes using time‐resolved phenotyping, elemental analysis ...
Stefan Sanow   +12 more
wiley   +1 more source

Adaptation of White Adipocytes to Cooler Temperatures: Impacts on Energy Metabolism and Protein Acetylation

open access: yesThe FASEB Journal, Volume 40, Issue 15, 15 August 2026.
Cultured white adipocytes exposed to 31°C undergo cell‐autonomous metabolic adaptation characterized by enhanced mitochondrial function and widespread remodeling of the mitochondrial acetylome. Acetyl‐proteomic and metabolomic profiling identified mitochondria‐associated proteins, including SHMT2 and PCCA, whose acetylation changes were linked to ...
Hiroyuki Mori   +11 more
wiley   +1 more source

Chemokine receptor CCR1 restrains adipose tissue remodelling via cAMP/PKA/CREB signalling and adipocyte‒macrophage crosstalk in mice

open access: yesClinical and Translational Medicine, Volume 16, Issue 8, August 2026.
CCR1 expression is significantly elevated in adipose tissue of obese individuals. Systemic and adipocyte‐specific Ccr1 deletion promotes fat browning via cAMP/PKA/CREB activation and M2 macrophage polarisation, protecting against obesity. Pharmacological blockade of CCR1 suppresses obesity progression, highlighting its potential as a novel target for ...
Suili Cai   +9 more
wiley   +1 more source

Traveling from the hypothalamus to the adipose tissue: The thermogenic pathway

open access: yesRedox Biology, 2017
Brown adipose tissue (BAT) is a specialized tissue critical for non-shivering thermogenesis producing heat through mitochondrial uncoupling; whereas white adipose tissue (WAT) is responsible of energy storage in the form of triglycerides. Another type of
Cristina Contreras   +4 more
doaj   +1 more source

Therapeutic Potential of Water‐Based Anatolian Propolis Extract Against CAF Diet‐Induced Obesity and Its Metabolic Complications

open access: yesFood Science &Nutrition, Volume 14, Issue 8, August 2026.
Water‐based Anatolian propolis extract attenuates CAF diet‐induced obesity‐related metabolic disturbances by improving dyslipidemia, hepatic injury, adipokine imbalance, and inflammatory status in C57BL/6 mice. ABSTRACT This study investigates the anti‐obesity effects of water‐based Anatolian propolis extract in mice with a cafeteria diet‐induced ...
Mehmet Kemal   +6 more
wiley   +1 more source

Marrow Adipose Tissue: Skeletal Location, Sexual Dimorphism, and Response to Sex Steroid Deficiency

open access: yesFrontiers in Endocrinology, 2017
Marrow adipose tissue (MAT) is unique with respect to origin, metabolism, and function. MAT is characterized with high heterogeneity which correlates with skeletal location and bone metabolism. This fat depot is also highly sensitive to various hormonal,
Beata Lecka-Czernik   +8 more
doaj   +1 more source

Metabolic Regulation of Macrophages in Health and Disease

open access: yesMedComm, Volume 7, Issue 8, August 2026.
Extracellular metabolites drive metabolic rewiring of glucose, lipid, and amino acid pathways in macrophages, steering their polarization toward pro‐ or anti‐inflammatory phenotypes and shaping a wide range of disease processes. Macrophages from different tissues display distinct metabolic signatures, and therapeutic strategies that target these ...
Shan Huang   +6 more
wiley   +1 more source

Brown adipose tissue and glucose homeostasis – the link between climate change and the global rise in obesity and diabetes

open access: yesAdipocyte, 2019
There is increasing evidence that the global rise in temperature is contributing to the onset of diabetes, which could be mediated by a concomitant reduction in brown fat activity.
Michael E. Symonds   +4 more
doaj   +1 more source

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