Results 101 to 110 of about 38,129 (248)

Multiomics analyses reveal that PRMT5 regulates membrane transport and cholesterol synthesis in white adipocytes

iMetaOmics, EarlyView.
Prmt5AKO downregulates genes related to fatty acid transport and triacylglycerol synthesis, while upregulating genes involved in glucose transport and cholesterol biogenesis. These changes cause alternation in lipid composition and metabolic phenotypes of Prmt5AKO mice. Abstract The adipose tissue (AT) is a main regulator of systemic energy homeostasis,
Xiyue Chen, Zhihao Jia, Xiashiyao Zhang, Feng Yue, James F. Markworth, Christina R. Ferreira, Jun Wan, Shihuan Kuang   +7 more
wiley   +1 more source

Enhancing phytochemical composition and nutritional profiles in dry bean varieties through roasting

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Dry beans and chickpeas are nutritionally valuable legumes widely consumed worldwide. This study examines the impact of oven roasting (110 °C for 70 min) on the phytochemical, antioxidant, fatty acid and saponin profiles of 12 pulses, including 11 common beans and 1 chickpea. RESULTS Roasting significantly affected the phytochemical
Olumide O Fashakin, Karen Cichy, Ilce G Medina‐Meza   +2 more
wiley   +1 more source

GQ-16, a TZD-derived partial PPARγ agonist, induces the expression of thermogenesis- related genes in brown fat and visceral white fat and decreases visceral adiposity in obese and hyperglycemic mice [PDF]

, 2016
Background Beige adipocytes comprise a unique thermogenic cell type in the white adipose tissue (WAT) of rodents and humans, and play a critical role in energy homeostasis.
Amato, Angélica Amorim, Báo, Sônia Nair, Christ, Camila G., Coelho, Michella S., Lima, Caroline Lourenço de, Lima, Maria do Carmo Alves de, Neves, Francisco de Assis Rocha, Oliveira, Fernanda C. B., Pereira, Sidney Alcântara, Pitta, Ivan da Rocha, Pitta, Marina Galdino da Rocha, Royer, Carine, Silva, Janaina Barbosa da   +12 more
core   +3 more sources

Inducible Brown Adipose Tissue, or Beige Fat, Is Anabolic for the Skeleton [PDF]

Endocrinology, 2013
Abstract It is known that insulin resistance and type 2 diabetes mellitus are associated with increased fractures and that brown adipose tissue (BAT) counteracts many if not all of the symptoms associated with type 2 diabetes. By the use of FoxC2AD+/Tg mice, a well-established model for induction of BAT, or beige fat, we present data ...
Sima Rahman, Beata Lecka-Czernik, Piotr J. Czernik, Yalin Lu, Sven Enerbäck, Clifford J. Rosen   +5 more
openaire   +3 more sources

(20R)-panaxadiol improves obesity by promoting white fat beigeing

Frontiers in Pharmacology, 2023
Introduction: Obesity is an important cause of a range of metabolic diseases. However, the complex mechanisms of obesity and its related diseases make some weight loss methods ineffective or have safety issues. Ginseng, a specialty of Jilin Province in China with both edible and medicinal value, contains mainly ginsenosides and other components.
Yuqian Lv, Xiaoyan Lv, Jianshu Feng, Fanghui Cheng, Zhiyi Yu, Zhiyi Yu, Fengying Guan, Li Chen   +7 more
openaire   +3 more sources

The Crystal Structure of Human Transport and Golgi Organization 2 Homolog (TANGO2) Protein Reveals an αββα‐Fold Arrangement

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Transport and Golgi Organization 2 Homolog (TANGO2) protein deficiency disorder (TDD) is a rare autosomal recessive disorder characterized by multi‐systemic abnormalities and significant phenotypic variability including neurodevelopmental delay, seizures, intermittent ataxia, hypothyroidism, rhabdomyolysis, life‐threatening metabolic ...
Anne Cooper, Alyssa Powers, Kevin P. Battaile, Al‐Walid Mohsen, David K. Johnson, Scott Lovell, Lina Ghaloul‐Gonzalez   +6 more
wiley   +1 more source

CMKLR1 senses chemerin/resolvin E1 to control adipose thermogenesis and modulate metabolic homeostasis

Fundamental Research
Induction of beige fat for thermogenesis is a potential therapy to improve homeostasis against obesity. β3-adrenoceptor (β3-AR), a type of G protein-coupled receptor (GPCR), is believed to mediate the thermogenesis of brown fat in mice.
Zewei Zhao, Siqi Liu, Bingxiu Qian, Lin Zhou, Jianglin Shi, Junxi Liu, Lin Xu, Zhonghan Yang   +7 more
doaj   +1 more source

Formation of thermogenic adipocytes: What we have learned from pigs

Fundamental Research, 2021
Thermogenic adipocytes, including brown and beige adipocytes, are capable of dissipating energy via heat production in response to external stimuli, such as cold exposure and exercise.
Jianguo Zhao, Cong Tao, Chuanhe Chen, Yanfang Wang, Tianxia Liu   +4 more
doaj   +1 more source

An OLTAM system for analysis of brown/beige fat thermogenic activity. [PDF]

Int J Obes (Lond), 2018
Thermogenic fat is present in humans and emerging evidence indicates that increasing the content and activity of these adipocytes may lead to weight loss and improved metabolic health. Multiple reporter systems have been developed to assay thermogenic fat activity based on the transcriptional and translational activation of Ucp1, the key molecule that ...
Kim DI, Liao J, Emont MP, Park MJ, Jun H, Ramakrishnan SK, Lin JD, Shah YM, Omary MB, Wu J.   +9 more
europepmc   +5 more sources

Perivascular adipose tissue inflammation in vascular disease [PDF]

, 2017
Perivascular adipose tissue (PVAT) plays a critical role in the pathogenesis of cardiovascular disease. In vascular pathologies, perivascular adipose tissue increases in volume and becomes dysfunctional, with altered cellular composition and molecular ...
Guzik, Tomasz J., Nosalski, Ryszard
core   +1 more source