Results 151 to 160 of about 38,129 (248)

Coordinate Functional Regulation between Microsomal Prostaglandin E Synthase-1 (mPGES-1) and Peroxisome Proliferator-activated Receptor y (PPARy) in the Conversion of White-to-brown Adipocytes [PDF]

, 2017
Peroxisome proliferator-activated receptor γ (PPARγ) is a ligand-activated nuclear receptor and a master regulator of adipogenesis. Microsomal prostaglandin E (PGE) synthase-1 (mPGES-1) is an inducible enzyme that couples with cyclooxygenase-2 for the ...
Arroyo, Vicente, Clària i Enrich, Joan, García-Alonso, Verónica, González Périz, Ana, López Vicario, Cristina, Morán-Salvador, Eva, Párrizas, Marcelina, Rius, Bibiana, Titos Rodríguez, Esther, Werz, Oliver   +9 more
core   +1 more source

In vivo emergence of beige-like fat in chickens as physiological adaptation to cold environments [PDF]

, 2021
Rina Sotome, Akira Hirasawa, Motoi Kikusato, Taku Amo, Kyohei Furukawa, Anna Kuriyagawa, Kouichi Watanabe, Anne Collin, Hitoshi Shirakawa, Ryota Hirakawa, Yuta Tanitaka, Hideki Takahashi, Guoyao Wu, Tomonori Nochi, Tsuyoshi Shimmura, Craig H. Warden, Masaaki Toyomizu   +16 more
openalex   +1 more source

Preadipocyte Uncoupling Protein 1 Expression Invoked by Fibroblast Growth Factors Imprints on Post‐Differentiation White and Brown Adipocyte Phenotype

The FASEB Journal, Volume 39, Issue 20, 31 October 2025.
Primary preadipocytes from inguinal white or interscapular brown fat were treated with paracrine fibroblast growth factors (FGF) 2, 4, 8, or 9. Treatment induced acute Ucp1 expression in preadipocytes, independent of other browning markers. Upon subsequent differentiation, Ucp1 and browning markers were expressed at levels comparable to untreated cells.
Katharina Kuellmer, Carolin Mönch, Wilma Roch, Christine Wurmser, Patricia S. S. Petersen, Hildigunnur Hermannsdóttir, Mersiha Hasic, Brice Emanuelli, Tobias Fromme   +8 more
wiley   +1 more source

Exercise-induced ‘browning’ of adipose tissues [PDF]

, 2017
Global rates of obesity continue to rise and are necessarily the consequence of a long-term imbalance between energy intake and energy expenditure. This is the result of an expansion of adipose tissue due to both the hypertrophy of existing adipocytes ...
Albrecht, Antonopoulos, Arner, Barreau, Berry, Bloor, Bogardus, Bordbar, Bostrom, Cannon, Carriere, Chaudhuri, Coelho, Craig Sale, Cypess, de Jong, De Matteis, Despres, Despres, Despres, Disanzo, DiSpirito, During, Emre, Fischer, Follenius, Fromme, Gagnon, Giralt, Haczeyni, Helen Budge, Hetzler, James Betts, Jespersen, Joyner, Kammoun, Kazak, Knudsen, Larue-Achagiotis, Liu, Long, M, Ma, Magkos, Maloney, Margaritis, Mark Pope, Marker, Matsushita, Michael E. Symonds, Nakhuda, Nielsen, Nozu, Oelkrug, Ostrowski, Palmer, Patsouris, Peppler, Peter Aldiss, Powers, Rao, Razzoli, Robciuc, Ronn, Sacks, Sanchez-Gurmaches, Scheele, Schreiber, Scott, Sengenes, Sepa-Kishi, Shabalina, Shimizu, Shin, Sidossis, Singhal, Stanford, Takx, Thomas, Thompson, Trayhurn, Tsiloulis, Tsoli, van Marken Lichtenbelt, Vergnes, Vieira, Virtanen, Vosselman, Woods, Wu, Wu, Yamashita, Yoneshiro   +92 more
core   +3 more sources

Synthesis of Urea‐Containing Derivatives and their Application as Potential Anti‐Methicillin‐Resistant Staphylococcus Aureus Agents

ChemMedChem, Volume 20, Issue 19, October 6, 2025.
A series of propylureido amides against methicillin‐resistant Staphylococcus aureus (MRSA) activity was prepared. The design involved replacing other hydrogen bond donors reported in FabI inhibitors with a urea moiety, while maintaining other pharmacophoric features.
Jorge A. González‐Cruz, Gerardo González‐Gallardo, J. Ricardo Pérez‐Velázquez, Carlos D. García‐Mejía, José Manuel Guevara‐Vela, Jesús A. Oria‐Hernández, Adriana Castillo‐Villanueva, Tomás Rocha‐Rinza, Eduardo Hernández‐Vázquez   +8 more
wiley   +1 more source

Multifaceted Roles of Beige Fat in Energy Homeostasis Beyond UCP1. [PDF]

Endocrinology, 2018
Abstract Beige adipocytes are an inducible form of thermogenic adipose cells that emerge within the white adipose tissue in response to a variety of environmental stimuli, such as chronic cold acclimation. Similar to brown adipocytes that reside in brown adipose tissue depots, beige adipocytes are also thermogenic; however, beige ...
Sponton CH, Kajimura S.
europepmc   +4 more sources

Co‐overexpression of the caloric restriction‐induced mitochondrial factors PGC‐1α and MIPEP upregulates Phospho1 expression in adipocytes

FEBS Open Bio, Volume 15, Issue 10, Page 1643-1657, October 2025.
Caloric restriction that extends lifespan induces the expression of PGC‐1α and MIPEP in white adipose tissue. In this study, co‐overexpression of Pgc‐1α and Mipep upregulated the gene expression of PHOSPHO1. These findings provide new insights into mitochondria‐related mechanisms underlying the effects of caloric restriction in adipocytes.
Mamiko Ishimatsu, Kanari Taki, Asuka Hayami, Komachi Kato, Yuka Nozaki, Yuhei Mizunoe, Takumi Narita, Ryoichi Mori, Yoshikazu Higami, Masaki Kobayashi   +9 more
wiley   +1 more source

The placenta, maternal diet and adipose tissue development in the newborn [PDF]

, 2017
Background: A majority of adipose tissue present in the newborn possess the unique mitochondrial protein, uncoupling protein (UCP1). It is thus highly metabolically active and capable of producing 300 times more heat per unit mass than any other organ in
Bloor, Ian, Budge, Helen, Ojha, Shalini, Symonds, Michael E.   +3 more
core   +2 more sources

Synergistic Effects of Bioactive Compounds on Human Adiposity Mechanisms of Fat Loss and Fat Accumulation

Food Science &Nutrition, Volume 13, Issue 10, October 2025.
Chronic diseases are associated with imbalances in adipose tissue, which plays a crucial role in regulating metabolic health. Food‐based bioactive substances (such as polyphenols, terpenoids, peptides, and fibers) impact fat metabolism by influencing the processes of lipolysis, adipogenesis, thermogenesis, and appetite control.
Mohamed Ibrahim Younis, Rawaa H. Tlay, Ammar B. Altemimi, Zheng Ruan, Tarek Gamal Abedelmaksoud   +4 more
wiley   +1 more source

Traveling from the hypothalamus to the adipose tissue: The thermogenic pathway

Redox Biology, 2017
Brown adipose tissue (BAT) is a specialized tissue critical for non-shivering thermogenesis producing heat through mitochondrial uncoupling; whereas white adipose tissue (WAT) is responsible of energy storage in the form of triglycerides. Another type of
Cristina Contreras, Rubén Nogueiras, Carlos Diéguez, Kamal Rahmouni, Miguel López   +4 more
doaj   +1 more source