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Brown and beige fat: From molecules to physiology
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2019The recent re-discovery of brown adipose tissue (BAT) and even more recent discovery of the browning of white adipose tissue (WAT) in humans have generated intense scientific interest in the role of adipose tissue as potential target against obesity and its metabolic complications.
Maria Chondronikola, Labros S. Sidossis
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Econutrition, brown and beige fat tissue and obesity.
Asia Pacific journal of clinical nutrition, 2020Obesity is caused by excessive fat accumulation or abnormal fat distribution and has become one of the biggest health challenges worldwide. Considering the high thermogenic ability of brown fat tissue (BAT) and the plasticity of fat tissue, to induce the browning of white fat tissue (WAT), so increasing BAT activity provides an attractive option for ...
Kelei Li +5 more
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Common traits between the beige fat-inducing stimuli
Current Opinion in Cell Biology, 2018Adipose tissues play an essential role in regulating the metabolic homeostasis and can be found in almost all parts of the body. Excessive adiposity leads to obesity and can contribute to metabolic and other disorders. Adipocytes show remarkable plasticity in their function, which can be pushed toward energy storage, or energy expenditure-a `browning ...
Stojanovic, Ozren +2 more
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A Creatine-Driven Substrate Cycle Enhances Energy Expenditure and Thermogenesis in Beige Fat
Cell, 2015 Lawrence Kazak +2 more
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In vivo metabolic imaging and monitoring of brown and beige fat
Journal of Biophotonics, 2018Activation of the thermogenic brown and beige fat is an effective means to increasing whole‐body energy expenditure. In this work, a unique label‐free method was developed to quantitatively assess the metabolism and thermogenesis of mouse adipose tissues in vivo.
He, Sicong +6 more
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Journal of Cellular Physiology
Transplantation of brown adipose tissue (BAT) is a promising approach for treating obesity and metabolic disorders. However, obtaining sufficient amounts of functional BAT or brown adipocytes for transplantation remains a major challenge.
Yuping Quan +5 more
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Transplantation of brown adipose tissue (BAT) is a promising approach for treating obesity and metabolic disorders. However, obtaining sufficient amounts of functional BAT or brown adipocytes for transplantation remains a major challenge.
Yuping Quan +5 more
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When fat cells are beige, future is brite
Science Translational Medicine, 2019Breast milk lipid mediators sustain brite fat development in infants, which may reduce their risk of future obesity.
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Parkin mediates mitophagy during beige-to-white fat conversion
Science Signaling, 2018Blocking Parkin-mediated mitophagy may help beige fat retain its thermogenic properties (Lu et al ., in 24 April 2018 issue).
Shireen A. Sarraf, Richard J. Youle
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Brown and beige fat: the metabolic function, induction, and therapeutic potential
Frontiers of Medicine, 2015Adipose tissue is an important organ for energy homeostasis. White adipose tissue stores energy in the form of triglycerides, whereas brown adipocytes and recently identified beige adipocytes are specialized in dissipating energy by thermogenesis or contribution to dispose glucose and clear triglycerides in blood.
Hai-Yan Huang, Shu-Wen Qian, Qi Qun Tang
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Dietary fatty acids activate or deactivate brown and beige fat.
Life Science, 2023Min Jia +3 more
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