Results 101 to 110 of about 4,340 (195)

A Phase 1 Pharmacokinetic and Pharmacodynamic Study of the Histone Deacetylase Inhibitor Belinostat in Patients with Advanced Solid Tumors

, 2008
Purpose: To determine the safety, dose-limiting toxicity, maximum tolerated dose, and pharmacokinetic and pharmacodynamic profiles of the novel hydroxamate histone deacetylase inhibitor belinostat (previously named PXD101) in patients with advanced ...
Tjornelund, J., Buhl-Jensen, P., Steele, N. L., Ooi, C. E., DeBono, J. S., Vidal, L., Knoblauch, P., Brown, R., Rasmussen, A., Plumb, J. A., Evans, T.R. J.   +10 more
core   +1 more source

Combination treatment of renal cell carcinoma with belinostat and 5-fluorouracil: A role for oxidative stress induced DNA damage and HSP90 regulated thymidine synthase

, 2015
Purpose Despite several therapeutic options renal cell carcinoma is associated with a poor clinical outcome. Therefore, we investigated whether combining 5-fluorouracil with the histone deacetylase inhibitor belinostat would exert a synergistic effect on
J S Lee, J Y Lee, S E Park, Jong Soon Kang, C S Kim, E K Choi, M J Kim, Ji Eun Yun, J J Hwang, H J Yi, I G Jeong, S Ro   +11 more
core   +1 more source

Augmented epigenetic repression of hepatitis B virus covalently closed circular DNA by interferon-α and small-interfering RNA synergy

mBio
The persistence of hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) is a key obstacle for HBV cure. This study aims to comprehensively assess the effect of interferon (IFN) and small-interfering RNA (siRNA) combination on the cccDNA ...
Kongying Hu, Wenjing Zai, Mingzhu Xu, Haiyu Wang, Xinluo Song, Chao Huang, Jiangxia Liu, Juan Chen, Qiang Deng, Zhenghong Yuan, Jieliang Chen   +10 more
doaj   +1 more source

Proteomic profiling of human colon cancer cells treated with the histone deacetylase inhibitor belinostat

, 2010
The anticancer drug belinostat is a hydroxamate histone deacetylase inhibitor that has shown significant antitumour activity in various tumour models and also in clinical trials.
Nielsen, Søren Jensby, Jensen, Peter Boie Lind, Morsczeck, Christian, Sehested, Maxwell, Morszeck, Christian, Jensen, Peter B., Maxwell Sehested, Peter B. Jensen, Christian Morszeck, Beck, Hans Christian, Grauslund, Morten, Hans Christian Beck, Søren Jensby Nielsen, Morten Grauslund, Petersen, Jørgen, Jørgen Petersen   +15 more
core   +1 more source

Supplementary Figures S1-S2 from Interactions between Bortezomib and Romidepsin and Belinostat in Chronic Lymphocytic Leukemia Cells

, 2008
Supplementary Figures S1-S2 from Interactions between Bortezomib and Romidepsin and Belinostat in Chronic Lymphocytic Leukemia ...
Lora B. Kramer (14910317), Paul Dent (6992573), Steven Grant (380210), Shuang Chen (12981), Yun Dai (380046), Vanessa L. Funk (7365206)   +5 more
core   +1 more source

Belinostat [PDF]

, 2020
openaire   +1 more source

Investigation of the effect of Belinostat (PXD101) on MCF-7 breast cancer stem cells

, 2019
Yüksek Lisans TeziMeme kanseri dünya genelinde olduğu gibi Türkiye'de de kadınlar arasında en sık görülen kanser türü olmaya devam etmektedir. Tümör gelişimi ve metastazından sorumlu olduğu düşünülen 'kanser kök hücreleri' kanser kitlesi içinde bulunan ...
Tuncer, Zeliha
core  

Interactive docking workshop: Docking the anticancer drug Belinostat to its cellular histone deacetylase (HDAC) target [PDF]

DockIT is an interactive molecular docking tool suitable for teaching students about concepts related to drug–receptor interaction. Its most unique feature is the ability to model both local and global conformational change in the receptor based on ...
Hayward, Steven, Laycock, Stephen D., Ganesan, A., Iakovou, Georgios, Kitao, Akio, Palmer, Leoni   +5 more
core   +1 more source

Belinostat Regimen [PDF]

, 2020
openaire   +1 more source

Integrated drug response prediction models pinpoint repurposed drugs with effectiveness against rhabdomyosarcoma.

PLoS ONE
Targeted therapies for inhibiting the growth of cancer cells or inducing apoptosis are urgently needed for effective rhabdomyosarcoma (RMS) treatment.
Bin Baek, Eunmi Jang, Sejin Park, Sung-Hye Park, Darren Reece Williams, Da-Woon Jung, Hyunju Lee   +6 more
doaj   +1 more source