Results 71 to 80 of about 11,846 (190)

Precision mRNA Delivery via Ultrasound‐Controlled Release Perfluorocarbon Emulsions: An Innovative Ultrasound Theranostic Strategy with 19F MRI Feasibility

Small, EarlyView.
A key challenge in advancing messenger RNA (mRNA) therapeutics in cardiovascular diseases lies in achieving controlled release at the precise site within the vasculature. This study presents the development of perfluorocarbon nanodroplets with exceptional theranostic potential, enabling real‐time tracking through ultrasound and fluorine‐19 (19F ...
Haikun Liu, Mark Louis P. Vidallon, Yuyang Song, Aidan P. G. Walsh, Henry Gordon, Shulei Ren, Pengkai Shi, Bangyan Xu, Mitchell J. Moon, Sylvain Trépout, Rico F. Tabor, Alexis I. Bishop, Ulrich Flögel, Karlheinz Peter, Xiaowei Wang   +14 more
wiley   +1 more source

Correlated analytical and functional evaluation of higher order structure perturbations from oxidation of NISTmAb

mAbs, 2023
The clinical efficacy and safety of protein-based drugs such as monoclonal antibodies (mAbs) rely on the integrity of the protein higher order structure (HOS) during product development, manufacturing, storage, and patient administration.
Tsega L. Solomon, Frank Delaglio, John P. Giddens, John P. Marino, Yihua Bruce Yu, Marc B. Taraban, Robert G. Brinson   +6 more
doaj   +1 more source

Divergent Phosphorus‐Mining Strategies in Simple and Compound Cluster Roots in Extremely Phosphorus‐Impoverished Soils in Southwest Australia

Plant, Cell &Environment, EarlyView.
ABSTRACT Most Proteaceae and some Fabaceae species produce specialised cluster roots (CRs), and are abundant in severely phosphorus (P)‐impoverished soils in southwest Australia. Two types of CRs, compound and simple, have been identified. However, the difference in their P‐mining strategies remains unclear. Therefore, we conducted glasshouse and field
Hirotsuna Yamada, Clément E. Gille, Pallavi, Li Yan, Gareth Nealon, Jun Wasaki, Erik J. Veneklaas, Hans Lambers   +7 more
wiley   +1 more source

Robotic arms for hyperpolarization-enhanced NMR

Journal of Magnetic Resonance Open
Optimization of nuclear spin hyperpolarization experiments often require varying one system parameter at a time (or several parameters in a nontrivial manner) as well as multiple repetitions of signal measurements.
Kirill Sheberstov, Erik Van Dyke, Jingyan Xu, Raphael Kircher, Liubov Chuchkova, Yinan Hu, Sulaiman Alvi, Dmitry Budker, Danila A. Barskiy   +8 more
doaj   +1 more source

Robotic Lepidoptery: Structural Characterization of (mostly) Unexpected Palladium Complexes Obtained from High-Throughput Catalyst Screening [PDF]

, 2009
In the course of a high-throughput search for optimal combinations of bidentate ligands with Pd(II) carboxylates to generate oxidation catalysts, we obtained and crystallographically characterized a number of crystalline products. While some combinations
Bercaw, John E., Day, Michael W., Golisz, Suzanne R., Hazari, Nilay, Henling, Lawrence M., Labinger, Jay A., Schofer, Susan J., Virgil, Scott   +7 more
core   +1 more source

Activation of proestrogens from hops (Humulus lupulus L.) by intestinal microbiota; Conversion of isoxanthohumol into 8-prenylnaringenin [PDF]

, 2005
Hop, an essential ingredient in most beers, contains a number of prenylflavonoids, among which 8-prenylnaringenin (8-PN) would be the most potent phytoestrogen currently known. Although a number of health effects are attributed to these compounds, only a
De Keukeleire, Denis, Heyerick, Arne, Possemiers, Sam, Robbens, Veerle, Verstraete, Willy   +4 more
core   +2 more sources

Analgesic effects of platelet‐rich fibrin (PRF): A systematic review

Periodontology 2000, EarlyView.
Abstract Background Platelet‐rich fibrin (PRF), a second‐generation autologous platelet concentrate, has gained significant interest for its anti‐inflammatory and regenerative characteristics. While its role in tissue healing is well‐recognized, the analgesic potential of PRF remains under‐investigated.
Nathan E. Estrin, Troy B. Tran, Paras Ahmad, Nima Farshidfar, Georgios E. Romanos, Anton Sculean, Richard J. Miron   +6 more
wiley   +1 more source

Comparative Genomics of Cyanobacterial Symbionts Reveals Distinct, Specialized Metabolism in Tropical Dysideidae Sponges. [PDF]

, 2019
Marine sponges are recognized as valuable sources of bioactive metabolites and renowned as petri dishes of the sea, providing specialized niches for many symbiotic microorganisms.
Agarwal, Agarwal, Antipov, Balskus, Bandaranayake, Bascom-Slack, Berthold, Blin, Boetzer, Bolger, Bowers, Broddrick, Burgsdorf, Calcul, Calteau, Capella-Gutiérrez, Carroll, Carroll, Carté, Crawford, Cummings, Donia, Eren, Finn, Flatt, Flowers, Gao, Gomez-Escribano, Harvey, Hinde, Hoang, Isaacs, Ishida, Kalyaanamoorthy, Kanehisa, Katoh, Kazlauskas, Kazlauskas, Kazlauskas, Klisch, Konstantinidis, Lackner, Langmead, Leao, Letunic, Marcais, Markowitz, Medema, Mehbub, Meyer, Moya, Myers, Nadalin, Newman, Nguyen, Parks, Paul, Peng, Penn, Podell, Podell, Porollo, Ridley, Rubin, Sakai, Schmidt, Schmidt, Sharma, Slaby, Thacker, Thacker, Unson, Unson, Wang, Weber, Wilson, Wu   +76 more
core   +1 more source

Increasing Infusion Times of Hyperpolarized [1‐13C]Pyruvate in a Mouse Brain Maintain Lactate Generation and Approach Pseudo‐Steady State Metabolism

Magnetic Resonance in Medicine, Volume 95, Issue 4, Page 2254-2265, April 2026.
ABSTRACT Purpose To investigate whether varying delivery times of hyperpolarized [1‐13C]pyruvate, enabled by the increased apparent T1 dissolved in deuterium oxide (D2O), affects the observed kinetics of glycolytic brain metabolism in vivo. Methods Eighteen healthy mice were injected with 300 μL of hyperpolarized [1‐13C]pyruvate dissolved in D2O at ...
Paola Porcari, Vesselin Miloushev, Saket Patel, Thasin Peyear, Marjan Berishaj, Kayvan R. Keshari   +5 more
wiley   +1 more source

Synthesis and late-stage functionalization of complex molecules through C-H fluorination and nucleophilic aromatic substitution. [PDF]

, 2014
We report the late-stage functionalization of multisubstituted pyridines and diazines at the position α to nitrogen. By this process, a series of functional groups and substituents bound to the ring through nitrogen, oxygen, sulfur, or carbon are ...
Fier, Patrick S, Hartwig, John F
core   +3 more sources