Results 121 to 130 of about 1,384,561 (311)

Ethical review key considerations for organoid applications in biomedical research—a systematic review

Frontiers in Cell and Developmental Biology
The organoid co-culture model, a novel tool for reconstructing three-dimensional microenvironments to study cell-cell interactions, has demonstrated significant potential in biomedical research in recent years. It holds considerable value for elucidating
Guo Zhili, Zhang Nenghua
doaj   +1 more source

Methodological guidelines and publications of benefit-risk assessment for health technology assessment: a scoping review protocol. [PDF]

BMJ Open, 2023
De Oliveira Ascef B, Gabriel FC, Suzumura EA, Maia FHA, Bortoluzzi AFR, Farias NS, Jahn B, Siebert U, De Soarez PC.   +8 more
europepmc   +1 more source

The use of biomarkers of toxicity for integrating in vitro hazard estimates into risk assessment for humans

, 2012
The role that in vitro systems can play in toxicological risk assessment is determined by the appropriateness of the chosen methods, with respect to the way in which in vitro data can be extrapolated to the in vivo situation.
Testai, E., Dep IRAS, Daneshian, M., Zurlo, J., Kramer, N.I., Leist, M., Risk Assessment of Toxic and Immunomodulatory Agents, Vandebriel, R.J., Goldberg, A.M., Seibert, H., Heneweer, M., Blaauboer, B.J., Boekelheide, K., Dingemans, M.M.L., Yager, J.D., Clewell, H.J., Jaworska, J.   +16 more
core  

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Benefit-risk assessment of brensocatib for treatment of non-cystic fibrosis bronchiectasis. [PDF]

ERJ Open Res, 2023
Chalmers JD, Metersky ML, Feliciano J, Fernandez C, Teper A, Maes A, Hassan M, Chatterjee A.   +7 more
europepmc   +1 more source

20220426_RAG_PRA_Hepatitis of unknown origin_children

, 2022
RAG PRA Hepatitis of unknown origin in Children 26-04 ...
Risk Assessment Group
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Improving exposure assessment of complex hydrocarbon mixtures in the aquatic environment

, 2011
Polycyclic Aromatic Hydrocarbons (PAHs) and oil are complex organic mixtures which are ubiquitously present in the aquatic environment. To prevent adverse effects on organisms exposed to these contaminants adequate risk assessment is of vital importance.
Dep IRAS, Risk Assessment of Toxic and Immunomodulatory Agents, Muijs, B.   +2 more
core  

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source