Results 91 to 100 of about 3,493,028 (307)

Assessment of Regranting Intermediaries Strategy: Exploring the Ecosystem of Support for Individual Artists & Small Arts Organizations in the San Francisco Bay Area [PDF]

, 2014
In March 2014, The William and Flora Hewlett Foundation engaged consultants from Olive Grove in partnership with Informing Change to assess the effectiveness of the Foundation's approach to support regranting intermediaries as a means to resource small ...

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Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Risk-Benefit Assessment of Carotid Revascularization

Arquivos Brasileiros de Cardiologia
Severe carotid atherosclerotic disease is responsible for 14% of all strokes, which result in a high rate of morbidity and mortality. In recent years, advances in clinical treatment of cardiovascular diseases have resulted in a significant decrease in ...
Pedro Piccaro de Oliveira, José Luiz da Costa Vieira, Raphael Boesche Guimarães, Eduardo Dytz Almeida, Simone Louise Savaris, Vera Lucia Portal   +5 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Uncertainty of net present value calculations and the impact on applying integrated maintenance approaches to the UK rail industry [PDF]

, 2015
The Public performance indicator (PPI) is an important Key Performance Indicator for Network Rail and monitored carefully by the organisation and their external stakeholders.
Andrew, Starr, Baguley, Paul, Kirkwood, Leigh, Shehab, Essam   +3 more
core   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Status quo of animal health of sows and piglets in organic farms [PDF]

, 2007
In an ongoing study, which focuses on the implementation of animal health plans in organic pig production, the status quo of animal health of sows and piglets in 20 organic farms in Germany was assessed. Standard livestock data showed distinct variations.
Dietze, Klaas, Sundrum, Albert, Werner, Christina   +2 more
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Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Burden Sharing Emissions and Climate Change: A Theoretic Welfare Approach [PDF]

The approximated cost-benefit function of pollution abatement from two integrated assessment models are employed in constructing of social welfare functions (SWF).
Dritan Osmani
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STREAM Journal, Vol. 3, No. 1, pp 1-18. January-March 2004 [PDF]

, 2002
CONTENTS: Creating understanding and ownership of collaborative research results through ‘learning by doing,’ by Robert Arthur and Caroline Garaway. Fish culture, farming, markets and promotion: an integrated, sustainable approach to aquaculture and ...

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