Results 81 to 90 of about 3,493,028 (307)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Benefit-risk assessment of vaccines

Vaccine
Benefit-risk assessment (BRA) is critical for decision-making throughout the vaccine life cycle. It requires scientific assessment of evidence to make an informed judgment on whether the vaccine has a favourable benefit-risk profile i.e. the benefits of the vaccine outweigh its risks for use in its intended indication. The assessment must also consider
Sonali Kochhar, Hector S. Izurieta, Rebecca E. Chandler, Adam Hacker, Robert T. Chen, Bennett Levitan   +5 more
openaire   +2 more sources

DO COLLEGE STUDENTS LEARN BY CORRECTING MISSED EXAM QUESTIONS? [PDF]

This study determines the learning benefit of correcting missed exam questions. The results show that in addition to exams being an assessment tool, they can also be used as a tool for student learning.
Bess, Erin, Green, V. Steven, Schroeter, Christiane   +2 more
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

ASSESSMENT OF PATIENT BENEFIT FROM SEPTOPLASTY WITH TURBINOPLASTY

Interdisciplinary Approaches to Medicine, 2021
Patients’ benefits and quality of life are profoundly influencing how health services are delivered. In recent years, there has been a trend in emphasis toward subjective outcome measures. Although the effects of septoplasty are not entirely comparable,
Ahmad Jawad Samadi
doaj  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Development of dietary assessment instruments which can take cultural diversity and dietary acculturation into account: eating in Sweden (‘Mat i Sverige’)

Journal of Nutritional Science
Since lack of culture-specific foods in dietary assessment methods may bias reported dietary intake, we identified foods and dishes consumed by residents not born in Sweden and describe consequences for reported foods and nutrient intake using a ...
Marleen A. H. Lentjes, Sarah Lönnström, Karin Lobenius Palmér, Zeinab Alsammarraie, Anna Karin Lindroos, Jessica Petrelius Sipinen, Afsaneh Koochek, Robert Jan Brummer, Scott Montgomery   +8 more
doaj   +1 more source

Hepatotoxicity induced by greater celandine (Chelidonium majus L.): a review of the literature [PDF]

, 2017
The available literature assessing Chelidonium majus L. (CM) hepatotoxicity potential, and its risk to benefit assessment has been reviewed in this paper.
Busardò, F. P, DI LUCA, Natale Mario, Gentili, S, Graziano, Silvia, Mannocchi, Giulio, Marinelli, Enrico, Pantano, Flaminia   +6 more
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Advancing environmental exposure assessment science to benefit society

Nature Communications, 2019
How can scientists and policymakers work together to reduce the health impacts of air pollution? In this review paper, the authors discuss the interplay between advances in environmental exposure assessment and policy advances to tackle pollution in a ...
Andrew Caplin, Masoud Ghandehari, Chris Lim, Paul Glimcher, George Thurston   +4 more
doaj   +1 more source