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Case Report: A potential novel treatment for drug-induced acute interstitial nephritis: Benralizumab. [PDF]
Saadia A +12 more
europepmc +1 more source
From Inflammation to Precision Medicine: Mechanistic Insights into Asthma, COPD, and IPF. [PDF]
Ghrairi N, Elhechmi YZ, Ben Saad S.
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Benralizumab for the treatment of asthma
Expert Review of Clinical Immunology, 2017Benralizumab is a humanized monoclonal antibody directed at the a subunit of the interleukin-5 receptor (IL-5R) that is under clinical development. The binding of benralizumab with the alpha chain of IL-5R results in inhibition of hetero-oligomerization of alpha and beta subunits and thus no signal transduction occurs.
Tara Vinyette Saco, Amber N Pepper
exaly +6 more sources
Benralizumab: First Global Approval
Kyowa Hakko Kirin, AstraZeneca and subsidiaries are developing benralizumab (Fasenra™)-a humanised anti-interleukin-5 receptor alpha chain (IL-5Rα) monoclonal antibody-as a treatment of severe eosinophilic asthma and chronic obstructive pulmonary disease (COPD).
A. Markham, Anthony Markham (4891627)
openaire +3 more sources
Unlocking the Long-Term Effectiveness of Benralizumab in Severe Eosinophilic Asthma: A Three-Year Real-Life Study [PDF]
Background: Benralizumab has been shown to restore good control of severe eosinophilic asthma (SEA). Robust data on benralizumab effectiveness over periods longer than 2 years are scarce.
Francesco Blasi +2 more
exaly +2 more sources
Benralizumab as a potential treatment of asthma
Expert Opinion on Biological Therapy, 2017Current anti-inflammatory asthma therapies including inhaled corticosteroids and leukotriene modifiers, are not always able to appropriately control the disease and other approaches are needed. These therapies specific target IgE (omalizumab) or IL-5 (mepolizumab).
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