Results 111 to 120 of about 24,787 (257)
Synthesis and Biological Activity of Benzamides Substituted with Pyridine-Linked 1,2,4-Oxadiazole
Molecules, 2020 To find pesticidal lead compounds with high activity, a series of novel benzamides substituted with pyridine-linked 1,2,4-oxadiazole were designed by bioisosterism, and synthesized easily via esterification, cyanation, cyclization and aminolysis ...
Sen Yang +7 more
doaj +1 more source
Identifying Drugs Associated With Parkinson's Disease Risk Using Machine Learning
Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 3, March 2026.ABSTRACT Machine learning (ML)–based methods have been proposed as a potential approach for identifying candidate drugs to be repurposed as disease‐modifying treatments for Parkinson's disease (PD). We applied an ML‐based signal detection method to identify drugs associated with PD and evaluated the method's generalizability.
Eeva Pylkkö +8 more
wiley +1 more source
Ab-initio crystal structure analysis and refinement approaches of oligo p-benzamides based on electron diffraction data [PDF]
, 2012 Ab-initio crystal structure analysis of organic materials from electron diffraction data is presented. The data were collected using the automated electron diffraction tomography (ADT) technique.
Brunklaus, Gunther +4 more
core +1 more source
Advanced Synthesis &Catalysis, Volume 368, Issue 3, 3 February 2026.A bench‐stable saccharin electrophilic reagent enables the direct installation of the heptafluoroisopropylthio group onto diverse (hetero)arenes and amines under mild conditions. The method forms CSRF and NSRF bonds in a single step and allows subsequent oxidation to sulfonamides.
Javier Jaureguizar +4 more
wiley +1 more source
Antiallergic Activity of Substituted Benzamides: Characterization, Estimation and Prediction [PDF]
, 2007 Antiallergic activity of twenty-three substituted N 4-methoxyphenyl benzamides was model by the use of an original methodology. After sketching out the compounds structure and creating the file with the observed activities, strictly based on compounds ...
BOLBOACA, Dr. Sorana D. +1 more
core
, 2004 Calothrixin A and B are novel pentacycIic qui nones that have been isolated from the Calothrix cyanobacteria. The calothrixins exhibit anti proliferative activity against chloroquine resistant strains of Plasmodium falciparum, the deadliest causative ...
Bernardo, Paul Huntington
core +1 more source
Identification of a novel polyprenylated acylphloroglucinol‑derived SIRT1 inhibitor with cancer‑specific anti-proliferative and invasion-suppressing activities [PDF]
, 2014 SIRT1, a class III histone deacetylase, plays a critical role in regulating cancer cell growth, migration and invasion, which makes it a potential target for cancer therapeutics.
Chiao, Christine Ya-Chi +6 more
core +2 more sources
Synthesis and Smo Activity of Some Novel Benzamide Derivatives
Molecules, 2017 Two series of benzamides compounds bearing piperidine groups were synthesized and the Gli-luc luciferase activity was screened by Gys-luc luciferase gene detection method. Compound 5q showed promising inhibition of hedgehog (Hh) signaling pathway.
Huaiwei Ding +8 more
doaj +1 more source
Neurogenesis and the Epigenetic Landscape: Role of Histone Modifications and Chromatin Remodeling
Brain and Behavior, Volume 16, Issue 2, February 2026.Histone methylation and acetylation modulate gene expression by inducing chromatin condensation or relaxation, which in turn regulates transcriptional activity and impacts neurogenesis. ABSTRACT Aims The purpose of this review is to examine how epigenetic regulation particularly chromatin modification and histone methylation controls gene expression ...
Degisew Yinur Mengistu +1 more
wiley +1 more source
Psychotropic Use Among Classroom Teachers in Espírito Santo: A Cross‐Sectional Study
Pharmacoepidemiology and Drug Safety, Volume 35, Issue 2, February 2026.ABSTRACT Purpose To assess the prevalence of psychotropic use among classroom teachers and to identify associated factors. Methods A cross‐sectional study was conducted between January and February 2024 in Espírito Santo, Brazil. The study included teachers from 20 state schools selected through probabilistic sampling.
Yohan Cancilheri Mazzini +5 more
wiley +1 more source