Results 111 to 120 of about 13,855 (240)

Development of Potent Type V MAPK Inhibitors: Design, Synthesis, and Biological Evaluation of Benzothiazole Derivatives Targeting p38α MAPK in Breast Cancer Cells

Archiv der Pharmazie, Volume 358, Issue 4, April 2025.
Type V MAPK inhibitors are unique for targeting both ATP and allosteric sites. In silico analysis and experimental methods were combined to optimize benzothiazole derivatives for antiproliferative activity against breast cancer cells. Two compounds showed significant inhibition of p38α MAPK, suggesting promising anticancer potential.
Bayan Zoatier, K. Gizem Yildiztekin, M. Abdullah Alagoz, Ceylan Hepokur, Serdar Burmaoglu, Oztekin Algul   +5 more
wiley   +1 more source

Ternary Complex Modeling, Induced Fit Docking and Molecular Dynamics Simulations as a Successful Approach for the Design of VHL‐Mediated PROTACs Targeting the Kinase FLT3

Archiv der Pharmazie, Volume 358, Issue 4, April 2025.
An efficient computational approach is presented for designing VHL‐mediated PROTACs by integrating static modeling, induced‐fit docking, and MD simulations. After being validated on four experimental ternary complexes targeting BRD4, SMARCA2, FAK, and WEE1, it was applied to an FLT3‐targeted PROTAC, MA49. MD simulations confirmed stability and provided
Husam Nassar, Anne‐Christin Sarnow, Ismail Celik, Mohamed Abdelsalam, Dina Robaa, Wolfgang Sippl   +5 more
wiley   +1 more source

Kinetics and Mechanism of the Oxidation of Benzamide by Silver(II), Cobalt(III) and Manganese(III) Ions in Aqueous Perchlorate Medium [PDF]

, 1983
FLROZ AHMAD, SUHAIL SABIR, V. S. BASWANI
openalex   +1 more source

Continuous Flow Synthesis of β‐Aminoketones as Masked Vinyl Ketone Equivalents

Chemistry – A European Journal, Volume 31, Issue 19, April 1, 2025.
We report an efficient and scalable method for the generation of β‐aminoketones from amides and Grignard reagents. The continuous process operates at elevated temperatures and uses a plate‐based reactor exploiting a hydrophobic internal coating to avoid reactor fouling issues due to the heterogeneous reaction mixture. The unmasking of the β‐aminoketone
Ruairi Bannon, Megan Smyth, Thomas S. Moody, Scott Wharry, Philippe M. C. Roth, Guillaume Gauron, Marcus Baumann   +6 more
wiley   +1 more source

Design, Synthesis and Anti‐Influenza Virus Activity of 4‐Tert‐Butyl‐N‐(3‐Oxo‐1‐Thia‐4‐Azaspiro[4.5]Dec‐4‐yl)Benzamide Derivatives That Target Hemagglutinin‐Mediated Fusion

Drug Development Research, Volume 86, Issue 2, April 2025.
ABSTRACT Hemagglutinin (HA) is a viral glycoprotein that mediates influenza virus entry into the host cell and is considered a relevant viral target. We here report the identification of a class of 4‐tert‐butylphenyl‐substituted spirothiazolidinones as HA‐mediated fusion inhibitors with specific activity against influenza A/H3N2 virus.
Gözde Çınar, Zeynep Alikadıoğlu, Özge Soylu‐Eter, Lieve Naesens, Gökçe Cihan‐Üstündağ   +4 more
wiley   +1 more source

Benzamide riboside induces apoptosis independent of Cdc25A expression in human ovarian carcinoma N.1 cells [PDF]

, 1999
Michael Grusch, Georg Rosenberger, Gerhard Fuhrmann, Katja Braun, Birgit Titscher, Thomas Szekeres, Monika Fritzer-Skekeres, Georg Oberhuber, Karsten Krohn, Markus Hengstschlaeger, Georg Krupitza, Hiremagalur N. Jayaram   +11 more
openalex   +1 more source

High Throughput Experimentation as a Tool to Guide the Microwave Assisted Catalytic Amidation of Aryl Amines with Aryl Acids

European Journal of Organic Chemistry, Volume 28, Issue 13, April 1, 2025.
We utilized DoE, HTE and microwave synthesis to develop a catalytic amidation protocol that follows the principles of green chemistry through use of catalysis to improve atom economy, biorenewable solvent, high substrate loadings and energy efficient microwave heating. Abstract The formation of amides is one of the most essential transformations in the
Giulia Murbach, Shruti A. Biyani, David H. Thompson   +2 more
wiley   +1 more source

Syntectonic melt pathways during simple shearing of a partially molten rock analogue (Norcamphor‐Benzamide) [PDF]

, 2000
Claudio Rosenberg, Mark R. Handy
openalex   +1 more source

Synthesis of Quinolino[4,3‐j]phenanthridines and their Photophysical Characterization

European Journal of Organic Chemistry, Volume 28, Issue 13, April 1, 2025.
Nine novel quinolino[4,3‐j]phenanthridines were successfully synthesized. UV/Vis and fluorescence spectroscopy revealed remarkable optoelectronic properties. Large Stokes shifts were especially observed for the protonated substrates. The experimental results were compared and complemented with quantum chemical calculations, providing further insights ...
Felix R. Schumann, Joachim Podlech
wiley   +1 more source

Synthesis of Unsymmetrical Urea Derivatives via PhI(OAc)₂ and Application in Late-Stage Drug Functionalization

Molecules
Unsymmetrical urea derivatives are essential structural motifs in a wide array of biologically significant compounds. Despite the well-established methods for synthesizing symmetrical ureas, efficient strategies for the synthesis of unsymmetrical urea ...
Subban Kathiravan, Prakriti Dhillon, Tianshu Zhang, Ian A. Nicholls   +3 more
doaj   +1 more source