Results 41 to 50 of about 14,481 (193)

Chromium-catalyzed para-selective formation of quaternary carbon centers by alkylation of benzamide derivatives

Nature Communications, 2018
The selective installation of quaternary carbon substituents on arenes is a highly challenging synthetic goal. Here, the authors report a chromium-catalyzed para-selective functionalization of benzamides with tertiary organometallic reagents under mild ...
Pei Liu, Changpeng Chen, Xuefeng Cong, Jinghua Tang, Xiaoming Zeng   +4 more
doaj   +1 more source

Synthesis of Functionalized 9-Substituted Fluorene Derivatives via Boron Trifluoride Catalysed Reaction of Coplanar 9-(Phenylethynyl)-9H-fluoren-9-ols, Aryl Aminoamides and N-Bromosuccinimide

SynOpen, 2021
A boron trifluoride catalysed reaction of coplanar 9-(phenyl­ethynyl)-9H-fluoren-9-ols with various 2-aminobenzamides affords a number of highly functionalized, conjugated (Z)-2-((2-(9H-fluoren-9-ylidene)-1-phenylethylidene)amino) benzamides in excellent
Mohanakumaran Athira, Ponnusamy Shanmugam   +1 more
doaj   +1 more source

The Mechanism of Visible‐Light Photochemical Rearrangements of Conjugated Amide Enolates

Chemistry – A European Journal, EarlyView.
Visible light irradiation of extended enolates of N‐benzylamides leads to homolytic C─N Bond cleavage, generating a biradical. Computational and mechanistic studies suggest rapid radical recombination within a solvent cage to give either ring‐expanded or rearranged products. ABSTRACT Deprotonation of conjugated amides forms colored solutions of lithium
James Mortimer, William Terry‐Wright, Basile F. E. Curchod, Jonathan Clayden   +3 more
wiley   +1 more source

2-(Methylsulfinyl)benzamide [PDF]

Acta Crystallographica Section E Structure Reports Online, 2010
In the crystal of the title compound, C(8)H(9)NO(2)S, synthesized by the oxidation of 2-(methyl-sulfan-yl)benzamide using NaOCl with 2,2,6,6-tetra-methyl-piperidyl-1-oxy (TEMPO) as the catalyst, mol-ecules are linked via inter-molecular N-H⋯O(amide) hydrogen bonds, forming centrosymmetric amide-amide dimers which are extended into a two-dimensional ...
openaire   +3 more sources

Matching TGF‐β1 Activation With Stress‐Responsive Charge‐Reversal Hydrogel Microspheres for the Treatment of Osteoarthritis

Exploration, EarlyView.
Based on the interaction between the weakly cross‐linked disulfide bonds that break under stress and charge‐reversal messenger molecules, we herein achieved nanoparticle charge reversal under stress and constructed a stress‐responsive charge‐reversal hydrogel microsphere system using microfluidic technology.
Feng Lin, Yiwen Xu, Lei Xiang, Yueliang Zhu, Yihan Li, Yaping Zhuang, Zengjie Zhang, Jiayu Chen, Heemin Kang, Ning Zhang, Xiaohua Yu, Wenguo Cui   +11 more
wiley   +1 more source

Discovery of (phenylureido)piperidinyl benzamides as prospective inhibitors of bacterial autolysin E from Staphylococcus aureus

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
Autolysin E (AtlE) is a cell wall degrading enzyme that catalyzes the hydrolysis of the β-1,4-glycosidic bond between the N-acetylglucosamine and N-acetylmuramic acid units of the bacterial peptidoglycan.
Jure Borišek, Sara Pintar, Mitja Ogrizek, Simona Golič Grdadolnik, Vesna Hodnik, Dušan Turk, Andrej Perdih, Marjana Novič   +7 more
doaj   +1 more source

Epigenetic Dysregulation of Somatostatin Receptors (SSTR) 1–5 and Therapeutic Implications in Neuroendocrine and Non‐Neuroendocrine Malignancies

International Journal of Cancer, EarlyView.
ABSTRACT Somatostatin receptors (SSTR) mediate the antiproliferative, antisecretory, and proapoptotic effects of somatostatin and its synthetic analogs. Their surface expression on neuroendocrine tumor (NET) cells is required for somatostatin analog therapy and radiopharmaceutical therapy (RPT).
Neeraj Kumari, Pablo Hoffmann, Laura Reichl, Maximilian Schmutz, Nina Fischer, Thi Tuong Vi Dang, Fulvia Ferrazzi, Pascal Johann, Michaela Kuhlen, Constantin Lapa, Rainer Claus   +10 more
wiley   +1 more source

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

Enantioselective Synthesis of Axially Chiral Diaryl Ethers via Rhodium‐Catalyzed [2 + 2 + 2] Cycloaddition

Angewandte Chemie, Volume 138, Issue 32, 3 August 2026.
An enantioselective rhodium‐catalyzed [2 + 2 + 2] cycloaddition enables the synthesis of axially chiral diaryl ethers. Carbonyl coordination ensures high reactivity and regioselectivity, affording products bearing up to four stereogenic axes with good enantio‐ and diastereoselectivity.
Yu Sato, Julong Jiang, Kairi Yamashiro, Ken Tanaka   +3 more
wiley   +2 more sources

Synthesis and Anti-inflammatory Activity of New 2,3-Dihydro-4(1H)-quinazolinone Derivatives

Zagazig Journal of Pharmaceutical Sciences, 2003
A new series of 2,3-dihydro-4(1H)-quinazolinones was synthesized by condensation of 2-methylamino-N-substituted benzamides (III) with either formaldehyde or aromatic aldehydes to produce 2,3-dihydro-1-methyl-3-(substituted phenyl)-4(1H) -quinazolinones ...
Samy Sakr
doaj   +1 more source