Results 61 to 70 of about 17,013 (236)

Substrate‐Selective Inhibition of the SARS‐CoV‐2 Papain‐Like Protease: Inhibition of Hydrolysis of Human Over Viral Substrates

Chemistry – A European Journal, EarlyView.
The SARS‐CoV‐2 papain‐like protease (PLpro) is a medicinal chemistry target. Here we report mass spectrometry assays employing oligopeptide substrates based on the sequences of the viral polyproteins 1a/1ab and on an ISG15‐modified human protein, which enabled the identification of substrate‐selective PLpro inhibitors.
Sakshi Sharma, Peter A. C. Wing, Wojtek Treyde, Shyam Basak, Simeon D. Draganov, Taylah Andrews‐Clark, Eidarus Salah, Petra Lukacik, Claire Strain‐Damerell, Adán Pinto‐Fernández, Martin A. Walsh, Fernanda Duarte, Christopher J. Schofield, Lennart Brewitz   +13 more
wiley   +1 more source

An effortless microwave synthesis of N-(aryl) substituted benzamides under solvent free conditions [PDF]

, 2020
Benzamides and substituted benzamides are versatile compounds used in a range of pharmacological and biological active intermediate chemicals for conversion to fine chemicals. The current syntheses protocols are chemical and energy intensive.
Rao, Sri Latha ; Department of Chemistry, Nitte Meenakshi Institute of Technology, Bengaluru 560 064, India, Molkere, Bhimashankar B; Green Chemistry Center, P E S University, Bengaluru 560 085, India, M, Veerabhadraswamy ; Green Chemistry Center, P E S University, Bengaluru 560 085, India   +2 more
core   +1 more source

The Mechanism of Visible‐Light Photochemical Rearrangements of Conjugated Amide Enolates

Chemistry – A European Journal, EarlyView.
Visible light irradiation of extended enolates of N‐benzylamides leads to homolytic C─N Bond cleavage, generating a biradical. Computational and mechanistic studies suggest rapid radical recombination within a solvent cage to give either ring‐expanded or rearranged products. ABSTRACT Deprotonation of conjugated amides forms colored solutions of lithium
James Mortimer, William Terry‐Wright, Basile F. E. Curchod, Jonathan Clayden   +3 more
wiley   +1 more source

Cobalt‐Catalyzed C(sp3)H Carbonylation Enabled by Mo(CO)6

European Journal of Organic Chemistry, EarlyView.
Cobalt‐catalyzed carbonylative C(sp3)H cyclization of aliphatic amides using Mo(CO)6 as a solid CO surrogate enables efficient access to substituted succinimides under operationally simple conditions. The carbonylation of unactivated C(sp3)H bonds represents an attractive strategy for the synthesis of valuable carbonyl‐containing compounds.
Emma Duro, Inés Alonso, Juan Carlos Carretero, Nuria Rodríguez, Javier Adrio   +4 more
wiley   +1 more source

Synthesis and Anti-inflammatory Activity of New 2,3-Dihydro-4(1H)-quinazolinone Derivatives

Zagazig Journal of Pharmaceutical Sciences, 2003
A new series of 2,3-dihydro-4(1H)-quinazolinones was synthesized by condensation of 2-methylamino-N-substituted benzamides (III) with either formaldehyde or aromatic aldehydes to produce 2,3-dihydro-1-methyl-3-(substituted phenyl)-4(1H) -quinazolinones ...
Samy Sakr
doaj   +1 more source

Expanding the Scope of 1,2‐Diazepines Through Alternative Activation Strategies

European Journal of Organic Chemistry, EarlyView.
Often overlooked due to tedious synthetic routes, 1,2‐diazepines can be found in handful of biorelevant molecules. Previous reports from our group lifted the principal synthetic lock: a rapid and user‐friendly protocol to reach monocyclic 1,2‐diazepines from readily available pyridines and electrophilic activating groups. Herein, we extend the scope of
Alexis Leblais, Diego Robles, Aurélie Damond, Xavier Moreau, Clément Ghiazza   +4 more
wiley   +1 more source

Bifunctional organocatalysts for the asymmetric synthesis of axially chiral benzamides

Beilstein Journal of Organic Chemistry, 2017
Bifunctional organocatalysts bearing amino and urea functional groups in a chiral molecular skeleton were applied to the enantioselective synthesis of axially chiral benzamides via aromatic electrophilic bromination.
Ryota Miyaji, Yuuki Wada, Akira Matsumoto, Keisuke Asano, Seijiro Matsubara   +4 more
doaj   +1 more source

FeIII‐Mediated Synthesis of Azaspirodienones via Ipso‐Radical Cyclization of Ugi–4CR Adducts

European Journal of Organic Chemistry, EarlyView.
An efficient two‐step protocol for the synthesis of azaspirodienones via Fe‐mediated ipso‐radical cyclization of Ugi adducts has been developed. This methodology provides rapid access to these privileged spirocyclic architectures under mild conditions, offering a practical and versatile approach to generating structurally complex molecules with ...
Silvia J. Becerra–Anaya, Valeria Morales–Hernández, Luis A. Polindara–García   +2 more
wiley   +1 more source

Isostructural Analysis in Proposed Crystallization Mechanisms at the Molecular Level of Methyl 4‐bromobenzoate and Methyl 4‐iodobenzoate

Helvetica Chimica Acta, EarlyView.
Proposed molecular‐level crystallization mechanisms for halogenated aryl esters were developed based on theoretical energetic and topological data regarding intermolecular and supramolecular interactions. Energetic analysis was used to determine the hierarchy of interactions guiding supramolecular structure growth along the three axes, as well as to ...
Patrick Teixeira Campos, Isabella Burchardt Ferreira, Rubia Mara Siqueira da Silva   +2 more
wiley   +1 more source

Kinetically Stable Boron‐Heteroatom Bonds

Angewandte Chemie, Volume 138, Issue 38, 14 September 2026.
This study investigates the kinetic stability of boron‐heteroatom bonds in N‐methyliminodiacetic acid (MIDA) boronates. The hemilabile nature of the ligand enables the synthesis of molecules that would otherwise be considered too hydrolytically labile. Depending on the structure, acid‐promoted migration of the boryl group was found to produce compounds
Alina Trofimova, Ben Zhen Huang, Harjeet S. Soor, Brandon White, Aleksandra Holownia, Yury Lebedev, Alan J. Lough, Travis Dudding, Andrei K. Yudin   +8 more
wiley   +2 more sources