Results 71 to 80 of about 15,060 (197)

Helical Single Crystals of Porous Hydrogen‐Bonded Organic Frameworks as a Candidate for Morphologically Functional Organic Materials

Angewandte Chemie, Volume 138, Issue 44, 26 October 2026.
Helical‐shaped crystals of a hydrogen‐bonded organic framework (HOF) with permanent porosity have been developed. The helical HOF shows expansion and contraction, respectively, upon desorption and adsorption of solvents. Moreover, doping of additive molecules can modulate the photophysical properties and morphology of the helical HOF, showing the ...
Yuzuki Murata, Taito Hashimoto, Ryusei Oketani, Miki Naruoka, Yuuya Nagata, Ryosuke Tamura, Masayuki Morimoto, Mio Yamashita, Daisuke Sakamaki, Norimitsu Tohnai, Hitoshi Asakawa, Ichiro Hisaki   +11 more
wiley   +2 more sources

Iodide/Nickel Co-Catalyzed Manganese-Mediated Denitrogenative Cross-Electrophile Coupling of Benzotriazinones with Alkyl Sulfonates

Molecules
An efficient Ni-catalyzed, Mn-mediated denitrogenative cross-electrophile coupling of N-alkyl-1,2,3-benzotriazinones with alkyl tosylates and mesylates for access to o-alkyl secondary benzamides is reported.
Yingying Hong, Xuanxuan Zhang, Gang Zou
doaj   +1 more source

NiH‐Catalyzed Enantio‐ and Regioselective Hydroselenylation of Unactivated Alkenes

Advanced Science, Volume 13, Issue 61, 3 November 2026.
Nickel‐hydride‐catalyzed enantio‐ and regioselective hydroselenylation of unactivated alkenes provides access to chiral organoselenium compounds. Enantiodetermining Ni–H insertion followed by single‐electron diselenide activation generates selenyl radical.
Hyung‐Joon Kang, Jaehun Kim, Sungwoo Hong   +2 more
wiley   +1 more source

Synthesis and Anti-inflammatory Activity of New 2,3-Dihydro-4(1H)-quinazolinone Derivatives

Zagazig Journal of Pharmaceutical Sciences, 2003
A new series of 2,3-dihydro-4(1H)-quinazolinones was synthesized by condensation of 2-methylamino-N-substituted benzamides (III) with either formaldehyde or aromatic aldehydes to produce 2,3-dihydro-1-methyl-3-(substituted phenyl)-4(1H) -quinazolinones ...
Samy Sakr
doaj   +1 more source

Novel Thiochroman‐4‐one Derivatives Bearing a Thiosemicarbazide Scaffold With Potential Antioxidant, α‐Glucosidase Inhibitory, and Antibacterial Activities

Chemistry &Biodiversity, Volume 23, Issue 11, November 2026.
Compound 6m displayed superior ABTS scavenging, α‐glucosidase inhibitory, and antibacterial activities, which were stronger than the positive controls. Molecular docking and MD simulations revealed stable interactions between compound 6m and the active site of human peroxiredoxin 5 (PDB ID: 4K7N) and human α‐glucosidase (PDB ID: 3TOP). ABSTRACT In this
Pei Li, Wenmin Pan, You Zhang, Xiang Wang   +3 more
wiley   +1 more source

Heparan Sulfate Differentially Regulates Fibroblast Binding by Extracellular Vesicles and Human Cytomegalovirus

Journal of Extracellular Vesicles, Volume 15, Issue 11, November 2026.
A model of EV and HCMV interactions with the fibroblast extracellular matrix. Heparan sulfate inhibits interactions between EVs and fibroblast cells bi‐directionally, while serving as the major cell attachment target for human cytomegalovirus (HCMV). EVs instead interact with collagen and fibronectin to facilitate fibroblast binding.
Vladimir Bokun, Antonio Di Maio, Yibing Zhang, Wengang Chai, Beth Holder, Yan Liu   +5 more
wiley   +1 more source

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, Volume 46, Issue 6, Page 1477-1498, November 2026.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

Optimized Roflumilast Ethosomal Gel for Enhanced Transdermal Therapy in Atopic Dermatitis: An In Vitro Study

ChemistryOpen, Volume 15, Issue 11, November 2026.
Roflumilast‐loaded ethosomal gel was developed and optimized using a Design of Experiments approach for enhanced transdermal delivery. The optimized RT‐5 formulation exhibited suitable pH, viscosity, spreadability, stability, and microbiological quality, achieving 99.34% drug penetration after 12 h, demonstrating promising topical delivery potential ...
Yasir Mehmood, Syeda Momena Rizvi, Atika Javed, Rida Siddique, Hamza Rafeeq, Hira Shahid, Ousman Brahim Mahamat, Hafiz Muhammad Zohaib, Khalid S. Almaary, Gamal A. Shazly, Musa A. Said, Turki M. Dawoud   +11 more
wiley   +1 more source

Histone deacetylase inhibitors as venetoclax‐sensitising partners in acute myeloid leukaemia: Mechanisms, pharmacology and translational perspectives

British Journal of Pharmacology, Volume 183, Issue 21, Page 6261-6290, November 2026.
Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley   +1 more source

4‐Thiazolidinone/2,4‐Thiazolidinedione–Sulfonamide Hybrids: A Concise Review of Their Design and Pharmacological Significance

ChemMedChem, Volume 21, Issue 20, 28 October 2026.
Sulfonamide–thiazolidinone hybrids integrate complementary pharmacophores to generate multifunctional scaffolds with broad pharmacological potential. Their structural versatility supports antimicrobial, antifungal, antioxidant, anticancer, anti‐inflammatory, antidiabetic, anticonvulsant, and enzyme‐inhibitory activities.
Subham Kumar Vishwakarma, Andressa Francielli Bonjorno, Sukhwant Singh, Christian S. Carnero Canales, Jean Leandro dos Santos, Cesar Augusto Roque‐Borda, Fernando Rogério Pavan   +6 more
wiley   +1 more source