Results 71 to 80 of about 17,013 (236)

Population pharmacokinetic-based dose adjustment of tiapride in patients with impaired renal function

Annals of Medicine
Background Tiapride is widely used for the treatment of confusion in the elderly and for other indications. Kidney impairment is common in the elderly population and may influence tiapride pharmacokinetics.
Barbora Agatha Halouzková, Michaela Jelínková, Jan Miroslav Hartinger, Martin Šíma, Zdenka Hrušková, Zuzana Hladinová, Tomáš Grus, Miroslav Špaček, Jan Škrha, Petr Toušek, Vladimír Tesař, Ondřej Slanař   +11 more
doaj   +1 more source

Epigenetic Dysregulation of Somatostatin Receptors (SSTR) 1–5 and Therapeutic Implications in Neuroendocrine and Non‐Neuroendocrine Malignancies

International Journal of Cancer, EarlyView.
ABSTRACT Somatostatin receptors (SSTR) mediate the antiproliferative, antisecretory, and proapoptotic effects of somatostatin and its synthetic analogs. Their surface expression on neuroendocrine tumor (NET) cells is required for somatostatin analog therapy and radiopharmaceutical therapy (RPT).
Neeraj Kumari, Pablo Hoffmann, Laura Reichl, Maximilian Schmutz, Nina Fischer, Thi Tuong Vi Dang, Fulvia Ferrazzi, Pascal Johann, Michaela Kuhlen, Constantin Lapa, Rainer Claus   +10 more
wiley   +1 more source

Gastrointestinal motility, prokinetic benzamides and serotonin : a study on the guinea-pig colon [PDF]

, 1995
The prokinetic substituted benzamides stimulate gastrointestinal motility in animal models and in man. Studies done on the isolated guinea-pig ileum have led to the hypothesis that the benzamides act through facilitation of cholinergic transmission due ...
Briejer, M.R.
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Anti-Parasite Activity of Novel 3,5-Diiodophenethyl-benzamides

, 2019
Novel iodotyramides with para-substituted benzoic acids were synthesized via electrophilic aromatic substitutions and amide coupling via N,N'-diisopropylcarbodiimide (DIC) in dimethylformamide (DMF).
Verónica Surmay Surmay (6210488), Manuel Pastrana Restrepo (6048593), Elkin Galeano Jaramillo (6048596), Sara Robledo Restrepo (6048605)   +3 more
core   +1 more source

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

Rh(III)-Catalyzed Coupling of Benzamides with Propargyl Alcohols via Hydroarylation Lactonization

, 2013
Rh(III)-Catalyzed Coupling of Benzamides with Propargyl Alcohols via Hydroarylation ...
孙佳琼, 李兴伟, 张雪林, 戚自松, 王芬   +4 more
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Asymmetric Synthesis of Axially Chiral Benzamides and Anilides by Enantiotopic Lithiation of Prochiral Arene Chromium Complexes

, 2016
Axially chiral benzamides and anilides were prepared by enantiotopic lithiation at the distinguished benzylic methyl of prochiral tricarbonylchromium complexes of N,N-diethyl 2,6-dimethylbenzamide (1) and N-methyl-N-acyl 2,6-dimethylaniline (14 and 21 ...
Motokazu Uemura (1891966), Takeshi Hata (223276), Hiroshige Koide (3029733)   +2 more
core   +1 more source

Species-specific pharmacology of Trichloro(sulfanyl)ethyl benzamides as transient receptor potential ankyrin 1 (TRPA1) antagonists

Molecular Pain, 2007
Agonists of TRPA1 such as mustard oil and its key component AITC cause pain and neurogenic inflammation in humans and pain behavior in rodents. TRPA1 is activated by numerous reactive compounds making it a sensor for reactive compounds in the body ...
Immke David C, Wang Weiya, Gao BaoXi, Tamir Rami, Klionsky Lana, Nishimura Nobuko, Gavva Narender R   +6 more
doaj   +1 more source

Comprehensive analysis of microtubule‐inhibiting herbicides reveals shared subcellular phenotypes and distinct resistance profiles

Pest Management Science, EarlyView.
Using cellular phenotyping and resistance profiling, we show that herbicides across the Herbicide Resistance Action Committee (HRAC) Groups 3 and 23 induce indistinguishable, dose‐dependent microtubule defects. Resistance patterns, rather than cellular phenotypes, reveal distinct sites of action and support reclassifying Group 3 as α‐tubulin binders ...
Katharina Kaprocki, Jennifer Blau, Michael Betz, Jessica Knox, Jens Lerchl, Philipp Johnen, Selene Garcia‐Hernandez   +6 more
wiley   +1 more source

Preparation of piperidinyl-alkyl-benzamides

, 1976
New piperidinyl-alkyl-benzamides and salts thereof are disclosed, together with a method for the production of the benzamides and salts. The benzamides, which have beta-adrenergic agonist effects, have the general formula ##STR1## The hydrochlorides ...
Roll, William D.
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