Results 71 to 80 of about 14,481 (193)

Substituted Benzamides Containing Azaspiro Rings as Upregulators of Apolipoprotein A-I Transcription

Molecules, 2012
Apolipoprotein A-I (Apo A-I) is the principal protein component of high density lipoprotein (HDL), which is generally considered as a potential therapeutic target against atherosclerosis.
Bin Hong, Xiao-Jian Jia, Xiao-Fang Chen, Shu-Yi Si, Li Wang, Wei Jiang, Yuan Yang, Yu Du   +7 more
doaj   +1 more source

Replacement soaking for human tankyrase 2 enables studies on substrate analogues and inhibitors

Acta Crystallographica Section D, Volume 82, Issue 8, Page 998-1008, August 2026.
Replacement soaking, also known as cross‐soaking, is a compelling method for solving complex structures in cases where traditional soaking and co‐crystallization approaches fail. This method is demonstrated with human tankyrase 2, and new crystal structures of complexes with nanomolar inhibitors and an analogue of the substrate NAD+ are reported ...
Johan Pääkkönen, Sven T. Sowa, Chiara Bosetti, Lari Lehtiö   +3 more
wiley   +1 more source

Chemical treatment rescues reduced growth of the autoimmune mutant chs3‐2D without compromising its immune responses

Plant Biology, Volume 28, Issue 5, Page 1686-1697, August 2026.
We generated a compound by chemical modification that can efficiently rescue growth without decreasing the immune response of the chs3‐2D autoimmune mutants, thus chemically uncoupling its growth–defence trade‐off. Abstract Plant development in many species including Arabidopsis relies on the accurate balance between growth and defence.
M. Keijzer, M. Liebers, J. Seufer, L. Voll, C. Meier, S. Hoth   +5 more
wiley   +1 more source

In silico identification of benzamide-based aryl halides as EGFR inhibitors: multi-ligand ADMET, pharmacophore mapping, and target prediction

In Silico Research in Biomedicine
Cancer is one of the greatest global health challenges, with specific costs of US$25 trillion by 2050, including treatment and socioeconomic impacts. The epidermal growth factor receptor (EGFR), a central tyrosine kinase, is a key target for anticancer ...
Caroline do Nascimento Gonçalves, Matheus Nunes da Rocha, Emmanuel Silva Marinho   +2 more
doaj   +1 more source

Evaluation of confirmatory data following the Article 12 MRL review and setting of an import tolerance for fluopyram in limes

EFSA Journal, Volume 24, Issue 8, August 2026.
Abstract The applicant Bayer AG Crop Science Division submitted a request to the competent national authority in Germany to evaluate the confirmatory data for the active substance fluopyram that were identified in the maximum residue levels (MRLs) review under Article 12 of Regulation (EC) No 396/2005.
European Food Safety Authority (EFSA), Giulia Bellisai, Giovanni Bernasconi, Irene Castellan, Monica del Aguila, Lucien Ferreira, Renata Leuschner, Andrea Mioč, Marta Szot, Manuela Tiramani, Alessia Verani   +10 more
wiley   +1 more source

Anticoccidial therapy small guide [PDF]

Medicamentul Veterinar, 2007
Being a major challenge, because of ingenious parasite's survival strategies and treatment's transience, anticoccidal therapy it is a major priority. In this respect, therapeutic conduct must be adjusted as well is possible on the most efficient drug ...
Cristina, T. Romeo
doaj  

Dilithium Enediamide Derived From 1,4‐Diaza‐1,3‐Diene: An Electron Reservoir Enabling Variable Reactivity Toward Carbonyl Compounds

European Journal of Inorganic Chemistry, Volume 29, Issue 21, 25 July 2026.
Upon reduction of 1,4‐diaza‐1,3‐diene 1 to the dilithium enediamide 2, the polarity of the C = N bonds is reversed ‐ a classic case of umpolung. This behavior is particularly evident in reactions of the dianion 2 with carbonyl compounds and also explains why 1,4‐diaza‐1,3‐diene ligands do not always act merely as spectator ligands. 1,4‐Diaza‐1,3‐dienes
Muhan Liang, Michael Kunze, Helmar Görls, Joachim Scholz   +3 more
wiley   +1 more source

Mechanistic Insights into the Antimicrobial Effect of Benzodioxane-Benzamides Against Escherichia coli

Antibiotics
Background/Objectives: The bacterial cell division machinery is emerging as an attractive target for antimicrobial compounds. FtsZ, a highly conserved essential division protein, is the target for a number of small molecules such as benzamides.
Lorenzo Suigo, Alessia Lanzini, Valentina Straniero, William Margolin   +3 more
doaj   +1 more source

Molecular Hybridization of Clinically Relevant P2X7 Antagonists

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
We employed a molecular hybridization strategy, combining clinically validated antagonists AZD‐9056 and JNJ‐54175446, to design and synthesize a library of novel adamantane‐containing P2X7R antagonists. Pharmacological and in silico analyses indicate that these adamantyl hybrids adopt a distinct, shallow binding mode within the P2X7R allosteric pocket,
Nicholas B. Lynch, Charleigh T. A. Agius, André D. J. McKenzie, Jessica O’Driscoll, Angus Tolmie, Taylor R. Garrett, Eryn Werry, Michael Kassiou   +7 more
wiley   +1 more source

An unusual endo-selective C-H hydroarylationof norbornene by the Rh(I)-catalyzed reactionof benzamides

Nature Communications, 2017
Investigating unusual organometallic pathways may help to efficiently control product selectivity in homogeneous catalysis. Here, the authors report the hydroarylation of aromatic amides with norbornene derivatives and propose the formation of a rhodium ...
Kaname Shibata, Satoko Natsui, Mamoru Tobisu, Yoshiya Fukumoto, Naoto Chatani   +4 more
doaj   +1 more source