Results 81 to 90 of about 15,060 (197)

FeIII‐Mediated Synthesis of Azaspirodienones via Ipso‐Radical Cyclization of Ugi–4CR Adducts

open access: yesEuropean Journal of Organic Chemistry, Volume 29, Issue 39, 22 October 2026.
An efficient two‐step protocol for the synthesis of azaspirodienones via Fe‐mediated ipso‐radical cyclization of Ugi adducts has been developed. This methodology provides rapid access to these privileged spirocyclic architectures under mild conditions, offering a practical and versatile approach to generating structurally complex molecules with ...
Silvia J. Becerra–Anaya   +2 more
wiley   +1 more source

Design, Synthesis and molecular docking study of hybrids of quinazolin-4(3H)-one as anticancer agents

open access: yesArs Pharmaceutica
A series of 4-(2-(4-substituted phenyl)-4-oxoquinazolin-3(4H)-yl)-N-(2-(4-fluorophenyl)-4-oxo-5-(arylidene)thiazolidin-3-yl) benzamides (VIa-n) have been synthesized by condensation of N-(2-(4-fluorophenyl)-4-oxothiazolidin-3-yl)-4-(4-oxo-2-(4 ...
Sukanya Nara, Achaiah Garlapati
doaj   +1 more source

Telluroesters: Synthesis and Reactivity in Nucleophilic Acyl Substitution

open access: yesAdvanced Synthesis &Catalysis, Volume 368, Issue 20, 16 October 2026.
A simple and general protocol to access telluroesters, a versatile class of organotellurium compounds serving as precursors of acyl radicals, is described. Their previously unexplored reactivity in nucleophilic acyl substitutions enables the efficient transfer of acyl moieties onto a broad range of nucleophiles under mild conditions.
Antonella Capperucci   +3 more
wiley   +1 more source

In silico identification of benzamide-based aryl halides as EGFR inhibitors: multi-ligand ADMET, pharmacophore mapping, and target prediction

open access: yesIn Silico Research in Biomedicine
Cancer is one of the greatest global health challenges, with specific costs of US$25 trillion by 2050, including treatment and socioeconomic impacts. The epidermal growth factor receptor (EGFR), a central tyrosine kinase, is a key target for anticancer ...
Caroline do Nascimento Gonçalves   +2 more
doaj   +1 more source

Benzoxazole-benzamide hybrids: synthesis, structure-activity relationships, and multi-biological evaluation. [PDF]

open access: yesRSC Med Chem
Galić M   +6 more
europepmc   +1 more source

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