Results 11 to 20 of about 17,199 (170)

Structure-based design of functionalized 2-substituted and 1,2-disubstituted benzimidazole derivatives and their in vitro antibacterial efficacy

Journal of Advanced Research, 2017
The aim of this present study was to synthesize 2-substituted and 1,2-disubstituted benzimidazole derivatives to investigate their antibacterial diversity for possible future drug design.
Olayinka O. Ajani, Olayinka O. Tolu-Bolaji, Shade J. Olorunshola, Yuxia Zhao, Damilola V. Aderohunmu   +4 more
doaj   +1 more source

Coumarin – benzimidazole hybrids: A review on diverse synthetic strategies

Results in Chemistry, 2022
Benzimidazole and coumarin are highly significant pharmacophores in medicinal chemistry due to their numerous and compelling biological activities. It has been found that combining two or more pharmacophores in a single moiety can improve the efficiency ...
C.G. Arya, Munugala Chandrakanth, K. Fabitha, Neethu Mariam Thomas, Rakendu N. Pramod, Ramesh Gondru, Janardhan Banothu   +6 more
doaj  

Benzimidazole and its derivatives: Recent Advances (2020–2022)

Results in Chemistry, 2023
Benzimidazoles are fused heterocyclic ring systems containing two nitrogen atoms. They have vital therapeutic significance in drug discovery. Many clinically approved drugs have been developed from benzimidazole, and these include liarozole and ...
Oluwakemi Ebenezer, Funsho Oyetunde-Joshua, Oluwadamilare D. Omotoso, Micheal Shapi   +3 more
doaj  

Resistance mutations impair benzimidazole efficacy against Ascaridia galli by altering β-tubulin interactions [PDF]

Microbes and Infectious Diseases
Background:  The emergence of benzimidazole resistance among helminths of veterinary and public health importance has been of grave concern. Benzimidazole resistance is caused by mutations (i.e., F167Y, E198A, and F200Y) that occur in the β-tubulin genes
Jan Clyden Tenorio
doaj   +1 more source

Understanding the inhibition performance of novel dibenzimidazole derivatives on Fe (110) surface: DFT and MD simulation insights

Journal of Materials Research and Technology, 2022
In order to delay or solve the issue of metal material corrosion, six benimidazole derivativesmolecules namely, 2,6- bis (benzimidazole-2′-yl) pyridine (A), 2,5- bis (benzimidazole -2′-yl) pyridine (B), 2,4- bis (benzimidazole -2′-yl) pyridine (C), 2,3 ...
Jianwei Zhu, Guanggang Zhou, Fanhong Niu, Yanyan Shi, Zishen Du, Guiwu Lu, Zilong Liu   +6 more
doaj  

2-n-Butyl-6-chloro-1-(2,4-dimethylphenylsulfonyl)-1H-benzimidazole–2-n-butyl-5-chloro-1-(2,4-dimethylphenylsulfonyl)-1H-benzimidazole (0.759/0.241)

Acta Crystallographica Section E, 2011
The title compound, 0.759C19H21ClN2O2S·0.241C19H21ClN2O2S, was synthesized by arylsulfonylation of 2-n-butyl-5-chloro-1H-benzimidazole in the presence of triethylamine.
K. B. Abdireymov, N. S. Mukhamedov, R. Ya. Okmanov, M. J. Ayimbetov, B. Tashkhodjaev   +4 more
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Benzimidazole: A versatile scaffold for drug discovery and beyond – A comprehensive review of synthetic approaches and recent advancements in medicinal chemistry

Results in Chemistry, 2023
Heterocyclic compounds are foundational in drug discovery, constituting the core structure of approximately 80% of pharmaceuticals. Benzimidazole, in particular, emerges as a critical aromatic heterocyclic system present in natural compounds, playing an ...
Neha D. Mahurkar, Nandkishor D. Gawhale, Mahendra N. Lokhande, Santosh J. Uke, Manisha M. Kodape   +4 more
doaj  

Antimicrobial potential of 1H-benzo[d]imidazole scaffold: a review

BMC Chemistry, 2019
Background Benzimidazole is a heterocyclic moiety whose derivatives are present in many of the bioactive compounds and posses diverse biological and clinical applications.
Sumit Tahlan, Sanjiv Kumar, Balasubramanian Narasimhan   +2 more
doaj   +1 more source

Review- biological active benzimidazole derivatives

Results in Chemistry, 2021
In the field of Medicinal Chemistry, the uses of heterocyclic compounds increased day by day, because in many biological materials, heterocyclic compound is a part of its structure.
Balasaheb Pathare, Tanaji Bansode
doaj  

Excited State Modulation in Carbene‐Metal‐Amides to Design Fast and Bright Blue Delayed Fluorescence

Advanced Functional Materials, EarlyView.
Gold‐centered carbene‐metal amide (CMA) materials with carbonyl‐group substitution on the amide donor ligand. Molecular design ensures that the charge transfer (CT) state is lower in energy than the locally excited (3LE) states. The energy difference between CT and LE states controls the rate of the delayed fluorescence.
Charlotte Riley, Nguyen Le Phuoc, Mikko Linnolahti, Alexander S. Romanov   +3 more
wiley   +1 more source