Results 21 to 30 of about 35,659 (254)

New Perspectives in Therapy of Intoxications by Organophosphoric Compounds

Eurasian Chemico-Technological Journal, 2003
Little references actually exist on neutralization therapy which could constitute the missing ring from an efficient treatment. As structural model capable to interact with organophosphoric substances, at the level of phosphor (P) atom, the common ...
V. Sunel, M. Popa, C. L. Dumitriu, O. Pintilie   +3 more
doaj   +1 more source

Benzimidazole-oxindole hybrids as multi-kinase inhibitors targeting melanoma

 In the current study, a series of benzimidazole-oxindole conjugates 8a-t were designed and synthesized as type II multi-kinase inhibitors. They exhibited moderate to potent inhibitory activity against BRAFWT up to 99.61 % at 10 µM. Notably, compounds 8e,
Kawkab A. Ahmed (10722190), Ahmed Elkerdawy (17157316), Heba T. Abdel-Mohsen (1923373), Ahmed Gouda (18069156), Rasha M. Allam (10862608)   +4 more
core   +5 more sources

Data on the effects of imidazo[1,2-a]benzimidazole and pyrimido[1,2-a]benzimidazole compounds on intraocular pressure of ocular normotensive rats

Data in Brief, 2018
This data is to document the intraocular pressure (IOP) lowering activity of imidazo[1,2-a]benzimidazole and pyrimido[1,2-a]benzimidazole compounds in ocular normotensive rats.
Adrian Julian Marcus, Igor Iezhitsa, Renu Agarwal, Pavel Vassiliev, Alexander Spasov, Olga Zhukovskaya, Vera Anisimova, Nafeeza Mohd Ismail   +7 more
doaj   +1 more source

A Comprehensive Account on Recent Progress in Pharmacological Activities of Benzimidazole Derivatives

Frontiers in Pharmacology, 2021
Nowadays, nitrogenous heterocyclic molecules have attracted a great deal of interest among medicinal chemists. Among these potential heterocyclic drugs, benzimidazole scaffolds are considerably prevalent.
Shejuti Rahman Brishty, Md. Jamal Hossain, Mayeen Uddin Khandaker, Mohammad Rashed Iqbal Faruque, Hamid Osman, S. M. Abdur Rahman   +5 more
doaj   +1 more source

Benzimidazole-derived carbohydrazones as dual monoamine oxidases and acetylcholinesterase inhibitors: design, synthesis, and evaluation

, 2023
A series of novel benzimidazole-derived carbohydrazones was designed, synthesized and evaluated for their dual inhibition potential against monoamine oxidases (MAOs) and acetylcholinesterase (AChE) using multitarget-directed ligand approach (MTDL).
Shivani Jaiswal (14124971), Sukesh Kumar Gupta (5874047), Senthil Raja Ayyannan (13270334), Sandeep Kumar (145759)   +3 more
core   +1 more source

Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC

Hepatology, EarlyView., 2022
Abstract Background and Aims Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3
Chupeng Hu, Bingqing Xu, Xiaodong Wang, Wen‐Hua Wan, Jinying Lu, Deyuan Kong, Yu Jin, Wenhua You, Hua Sun, Xiaoxin Mu, Dongju Feng, Yun Chen   +11 more
wiley   +1 more source

sj-pdf-1-hip-10.1177_09540083211036326 – Supplemental Material for Preparation and characterization of soluble heat-resistant polyimide films containing bis-N-phenyl-benzimidazole

, 2021
Supplemental Material, sj-pdf-1-hip-10.1177_09540083211036326 for Preparation and characterization of soluble heat-resistant polyimide films containing bis-N-phenyl-benzimidazole by Dandan Li, Chengyang Wang, Shengqi Ma, Hongwei Zhou and Ran Lu in High ...
Chengyang Wang (390546), Ran Lu (488619), Dandan Li (391591), Hongwei Zhou (93199), Shengqi Ma (7355804)   +4 more
core   +1 more source

Direct Access to Chiral Piperidines by Enantioselective HAT‐Initiated C(sp3)─H Oxidation

Angewandte Chemie, EarlyView.
The direct desymmetrization of piperidines is achieved through manganese‐catalyzed enantioselective α‐C(sp3)─H oxidation with hydrogen peroxide, affording versatile chiral N,O‐acetals in good yields and with high enantio‐ and diastereoselectivity. These intermediates provide access to diverse functionalized piperidines with retention of chirality ...
Sethuraman Muthuramalingam, Josep M. Luis, Arnau Call, Quentin Lefebvre, Matthew S. Sigman, Miquel Costas   +5 more
wiley   +2 more sources

Progress in Synthesis and Pharmacology of Telmisartan. [PDF]

Chem Biodivers
Telmisartan is a benzimidazole derivative and a well‐known drug to treat hypertension. This review provides synthesis and understanding of telmisartan as an antihypertensive drug through two mechanisms of actions: RAAS inhibitor and PPARγ receptor. Effective repurposing of this drug for various diseases like chronic kidney illness, diabetes, fatty ...
Megha, Srivastava R, Singh R.
europepmc   +2 more sources

2-n-Butyl-6-chloro-1-(2,4-dimethylphenylsulfonyl)-1H-benzimidazole–2-n-butyl-5-chloro-1-(2,4-dimethylphenylsulfonyl)-1H-benzimidazole (0.759/0.241)

Acta Crystallographica Section E, 2011
The title compound, 0.759C19H21ClN2O2S·0.241C19H21ClN2O2S, was synthesized by arylsulfonylation of 2-n-butyl-5-chloro-1H-benzimidazole in the presence of triethylamine.
K. B. Abdireymov, N. S. Mukhamedov, R. Ya. Okmanov, M. J. Ayimbetov, B. Tashkhodjaev   +4 more
doaj   +1 more source