Results 181 to 190 of about 636,119 (261)

Broccoli Sprout Extract Restores Renal Lipid Metabolism in High‐Fat Diet‐Fed Mice Involving Modulation of AMPK/Nrf2 Signaling and the NLRP3 Inflammasome

Food Science &Nutrition, Volume 14, Issue 9, September 2026.
High‐fat diet (HFD) induces renal lipid accumulation, AMPK suppression, oxidative stress, and NLRP3 inflammasome activation, leading to renal injury. Broccoli sprout extract (BSE) concurrently activates AMPK signaling (promoting fatty acid oxidation and inhibiting lipogenesis), enhances Nrf2‐mediated antioxidant defense, and suppresses NLRP3‐driven ...
Chunting Wu, Bangzhao Zeng, Xuexun Li, Xin Zhao, Junyu Ma, Mengxue Zhang, Shuangshuang Zhao, Chunmei Zhang, Qin Gao, Fuli Ya   +9 more
wiley   +1 more source

New Amidino-Substituted Benzimidazole Derivatives as Human Dipeptidyl Peptidase III Inhibitors: Synthesis, In Vitro Evaluation, QSAR, and Molecular Docking Studies. [PDF]

Int J Mol Sci
Agić D, Karnaš Babić M, Hranjec M, Šubarić D, Karačić Z, Abramić M.   +5 more
europepmc   +1 more source

Comprehensive Investigation of Benzimidazolium Derivatives Through Synthesis, Characterization, Cytotoxicity Activity, Immunocytochemistry, and ADME and Toxicity Analyses

ChemistryOpen, Volume 15, Issue 9, September 2026.
Three benzimidazolium derivatives bearing fluoro, chloro, and methoxy substituents are synthesized and evaluated for anticancer activity. Compound 2b shows the highest antiproliferative activity and induces apoptosis through caspase‐3 activation and PARP1 cleavage. In this study, three novel benzimidazolium derivatives (2a–c) bearing 4‐fluoro, 3‐chloro,
Gulay Dilek, Senem Akkoc
wiley   +1 more source

Human Cytomegalovirus Genetic Diversity, Clinical Relevance, and Emerging Insights

Reviews in Medical Virology, Volume 36, Issue 5, September 2026.
ABSTRACT Human cytomegalovirus (HCMV) is a globally prevalent virus that poses a significant public health concern, especially for newborns and immunocompromised patients, causing a wide range of infections. Clinical outcomes associated with HCMV infection include congenital disease, graft rejection in transplant recipients, and life‐threatening ...
Hajar Y. AlQahtani, Fadilah Sfouq Aleanizy, Fulwah Yahya Alqahtani   +2 more
wiley   +1 more source

Design and Synthesis of a Potent, Cell Active Purine‐Based Amidoxime Against the Dengue Virus

ChemistrySelect, Volume 11, Issue 36, 22 September 2026.
Scaffold hopping from our previous indolazepinone hit exemplifies purine SP‐835G with DENV2 EC50 0.1 µM, CC50>100 µM, clogP 3.61. Docking studies support its amidine metabolite operates as an allosteric inhibitor of DENV(pro). A flexible ether linker appears pivotal for enhancing binding and activity.
Dimitrios Kiousis, Despoina Giannioti, Georgia Kalyva, Vasiliki Zogali, Maharah Binte Abdul Mahid, Kitti Wing Ki Chan, Minos‐Timotheos Matsoukas, Subhash G. Vasudevan, Gerasimos Rassias   +8 more
wiley   +1 more source

Emerging Chemical Upcycling and Repurposing Strategies for Waste Pharmaceuticals

ChemistrySelect, Volume 11, Issue 36, 22 September 2026.
What could be done with pharmaceutical waste from a circular chemistry perspective? A literature survey was conducted using the terms “recycling”, “upcycling”, “reuse”, “repurposing”, “pharmaceutical”, “expired drug”, “expired medicine”, “unused drug” and “unused medicine” in the databases Scopus, Web of Science and Periódicos CAPES to answer this ...
Letícia Ribeiro Magalhães, Lourena Mafra Veríssimo, Euzébio Guimarães Barbosa, Alessandro Kappel Jordão   +3 more
wiley   +1 more source

New benzimidazole derivatives containing hydrazone group as anticancer agents: Inhibition of carbonic anhydrase IX and molecular docking studies. [PDF]

Arch Pharm (Weinheim)
Bostancı HE, Yıldız MT, Kapancık S, Şahin Inan ZD, Kılıç HA, Özensoy Güler Ö, Acar Çevik U, Özkay Y, Kaplancıklı ZA.   +8 more
europepmc   +1 more source

Clinical Molecular Investigation of Encephalitozoon cuniculi in Pet Rabbits: Early Detection of Potential Risk for Animal and Human Infection

Veterinary Medicine and Science, Volume 12, Issue 5, September 2026.
This study assesses the presence, genotypes and clinical signs of E. cuniculi infection in pet rabbits in Slovenia. Molecular analysis reveals the presence of E. cuniculi DNA (Genotype I) in 14.98% rabbit urine samples, mostly in rabbits with signs of urinary tract disorders.
Maruša Škrbec, Brigita Slavec, Nina Kočar, Katarina Modrijan, Urška Kuhar, Marko Kolenc, Alenka Dovč, Olga Zorman Rojs, Jožko Račnik   +8 more
wiley   +1 more source

Sustainable Synthesis of Polyfluoro-Pyrimido [1,2-<i>a</i>] Benzimidazole Derivatives Using a Tandem Strategy─Ultrasound and an Integrated Continuous Flow System. [PDF]

J Org Chem
Thavasianandam Seenivasan V, Chen NQ, Govindan K, Jayaram A, Lin YC, Li CH, Lin WY.   +6 more
europepmc   +1 more source

Drug Resistance Assessment of Commonly Used Anthelmintics, and Their Combination Effect in Naturally Infected Sheep: The Case of Kaffa Zone, Southwestern Ethiopia

Veterinary Medicine and Science, Volume 12, Issue 5, September 2026.
This study evaluated the efficacy of widely used commercial anthelmintics and examined whether combining different drug classes enhances their effectiveness in naturally infected sheep in the Kaffa Zone. This study suggest the presence of emerging anthelmintic resistance to albendazole and tetramisole in the study area and highlight the potential ...
Nahom Belay, Asrat Arke, Lamrot Tesfaye
wiley   +1 more source