Results 191 to 200 of about 636,119 (261)

Influence of Solvents and Halogenation on ESIPT of Benzimidazole Derivatives for Designing Turn-on Fluorescence Probes. [PDF]

ACS Omega
Queiroz MH, Alves TV, Rivelino R, Canuto S.   +3 more
europepmc   +1 more source

YK‐4‐250, a synthetic telmisartan–tempol conjugate: crystal structure of a stabilized free radical containing an angiotensin AT1 receptor inhibitor

Acta Crystallographica Section C, Volume 82, Issue 9, Page 547-552, September 2026.
The first crystal structure of the telmisartan–tempol conjugate YK‐4‐250 is reported, revealing the intramolecular C–H…π interactions that stabilize the nitroxide radical while preserving the angiotensin AT1 receptor antagonist pharmacophore.We report the first crystal structure of the telmisartan–tempol conjugate 2,2,6,6‐tetramethyl‐1‐(λ′‐oxidaneyl ...
Simon Friedrich, Yali Kong, Faik N. Musayev, Milton L. Brown, B. Frank Gupton   +4 more
wiley   +1 more source

Synthesis and anti-inflammatory activity of benzimidazole derivatives; an in vitro, in vivo and in silico approach. [PDF]

Heliyon
Bano S, Nadeem H, Zulfiqar I, Shahzadi T, Anwar T, Bukhari A, Masaud SM.   +6 more
europepmc   +1 more source

Iso‐ and Benzisothiazolinone Inhibitors of Monoacylglycerol Lipase: Exploring On‐Target Activity Through Scaffold Decoration and In Situ Warhead Generation

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
We explore covalent allosteric targeting of MGL regulatory cysteines using iso‐ and benzisothiazolinone scaffolds. Combining mechanism‐based warhead release with structure‐guided scaffold decoration to improve molecular recognition, this study probes strategies to achieve selective on‐target engagement beyond the catalytic site. Monoacylglycerol lipase
Edoardo Rocca, Annalida Bedini, Laura Scalvini, Francesca Galvani, Riccardo Castelli, Lorenzo Sarcone, Adriano Recchia, Fabiola Fanini, Adren Tran, Silvia Rivara, Gilberto Spadoni, Daniele Piomelli, Marco Mor   +12 more
wiley   +1 more source

Molecular Modeling, Synthesis, and Antihyperglycemic Activity of the New Benzimidazole Derivatives - Imidazoline Receptor Agonists. [PDF]

Drug Des Devel Ther
Martynov A, Farber B, Bomko T, Beckles DL, Kleyn I.   +4 more
europepmc   +1 more source

Targeting Human Immunodeficiency Virus Integrase Beyond the Active Site: The Discovery and Development of Allosteric Integrase Inhibitors

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
Human immunodeficiency virus (HIV) allosteric integrase inhibitors (ALLINIs) offer a vital alternative to standard therapies by targeting noncatalytic sites. By inducing aberrant integrase multimerization, they disrupt viral maturation. This review explores their medicinal chemistry evolution, detailing structural insights, structure–activity ...
Francesco Saccoliti, Elisa Patacchini, Emanuele Cara, Laura Zarbo, Antonella Messore, Aurora Albano, Giuseppe Ruggieri, Valentina Noemi Madia, Luigi Scipione, Roberta Costi, Roberto Di Santo   +10 more
wiley   +1 more source

Microwave assisted palladium catalyzed carbon-carbon bond formation to synthesise novel benzimidazole derivatives and their Photophysical properties, molecular docking, and DFT study. [PDF]

Heliyon
Sundharaj V, Sarveswari S.
europepmc   +1 more source

Corrosion inhibition performance of benzimidazole derivatives for protection of carbon steel in hydrochloric acid solution. [PDF]

RSC Adv
Timoudan N, Al-Gorair AS, El Foujji L, Warad I, Safi Z, Dikici B, Benhiba F, Qaiss AEK, Bouhfid R, Bentiss F, Al-Juaid SS, Abdallah M, Zarrouk A, Zarrouk A.   +13 more
europepmc   +1 more source

Benzimidazole derivatives as a new scaffold of anticancer agents: Synthesis, optical properties, crystal structure and DFT calculations. [PDF]

Heliyon
Zouaghi MO, Bensalah D, Hassen S, Arfaoui Y, Mansour L, Özdemir N, Bülbül H, Gurbuz N, Özdemir I, Hamdi N.   +9 more
europepmc   +1 more source

Synthesis, Molecular Docking, Molecular Dynamic Simulation Studies, and Antitubercular Activity Evaluation of Substituted Benzimidazole Derivatives. [PDF]

Adv Pharmacol Pharm Sci
Thapa S, Biradar MS, Nargund SL, Ahmad I, Agrawal M, Patel H, Lamsal A.   +6 more
europepmc   +1 more source