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Comparative Experimental Pharmacokinetics of Benzimidazole Derivatives
Bulletin of Experimental Biology and Medicine, 2008Comparative study of experimental kinetics of distribution of benzimidazole derivatives (bemithyl, etomerzole, and thietazole) in organs and tissues was carried out after single and course treatment. The drugs intensely passed into organs and tissues from the blood after treatment by all protocols.
S A, Sergeeva, I L, Gulyaeva
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Benzimidazole derivatives with atypical antiinflammatory activity
Journal of Medicinal Chemistry, 1987A number of substituted 2-[(2,2,2-trifluoroethyl)sulfonyl]-1H-benzimidazoles (4) have demonstrated antiinflammatory activity that appears to have a mechanism distinct from typical cyclooxygenase inhibiting nonsteroidal antiinflammatory drugs. Several of these compounds inhibit adjuvant-induced arthritis in rats at 25 mg/kg while showing no activity in ...
E S, Lazer, M R, Matteo, G J, Possanza
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Ytterbium Triflate Promoted Synthesis of Benzimidazole Derivatives.
ChemInform, 2004AbstractFor Abstract see ChemInform Abstract in Full Text.
CURINI, Massimo +4 more
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Anti-Inflammatory Trends of New Benzimidazole Derivatives
Future Medicinal Chemistry, 2016In present study, the anti-inflammatory activities of a new series of benzimidazole derivatives were studied, investigating their inhibition of secretory phospholipase A2, lipoxygenase, COXs and lipopolysaccharide-induced secretion of TNF-α and IL-6 in mouse RAW264.7 macrophages.Synthesized compounds effectively inhibited proinflammatory enzymes and ...
Bukhari, Syed Nasir Abbas +8 more
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Interaction of anthelmintic benzimidazoles and benzimidazole derivatives with bovine brain tubulin
Biochimica et Biophysica Acta (BBA) - General Subjects, 1978The binding and inhibitory properties of 11 benzimidazoles for bovine brain tubulin were investigated. The effects of the benzimidazoles on the initial rates of microtubule polymerization were determined by a turbidimetric assay. The median inhibitory concentrations (I50) for nocodazole, oxibendazole, parbendazole, mebendazole and fenbendazole ranged ...
P A, Friedman, E G, Platzer
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Research on benzimidazole derivatives
Chemistry of Heterocyclic Compounds, 1976A. M. Simonov, V. N. Komissarov
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Investigation of benzimidazole derivatives
Chemistry of Heterocyclic Compounds, 1972M. M. Medvedeva +2 more
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