Results 111 to 120 of about 13,158 (230)

PIII/PV Redox Organocatalysis Enables Intramolecular Aza‐Wittig Cyclizations of Imides: Direct Access to Pharmaceutically Relevant Amidine Scaffolds

Advanced Synthesis &Catalysis, Volume 368, Issue 16, 18 August 2026.
A metal‐free PIII/PV redox organocatalytic aza‐Wittig reaction enables the efficient cyclization of azide‐functionalized imides into pharmaceutically relevant amidine‐containing heterocycles. Using only 2 mol% of a methanophosphocine catalyst and a Brønsted acid additive, a broad range of substrates is converted in up to 96% yield, including ...
Raphael El Bekri Saudain, Pierre‐Olivier Butin, David Virieux, Tahar Ayad   +3 more
wiley   +1 more source

Synthesis and Antiparasitic Activities of New Organometallic Derivatives of the Benzimidazole Anthelmintic Drugs

ChemBioChem, Volume 27, Issue 15, 14 August 2026.
Organometallic derivatization of existing drugs is a common strategy to look for new drug candidates. This work describes the derivatization of the benzimidazole anthelmintic scaffold, from the synthesis of the organometallic derivatives to the evaluation of their biological properties. It highlights a broad range of antiparasitic activities and leaves
Corentin Ludwig, Aya C. Taki, Joseph J. Byrne, Pierre Mesdom, Olivier Blacque, Cécile Häberli, Trix Zumkehr, Gonzalo Scalese, Leticia Pérez‐Díaz, Dinorah Gambino, Britta Lundström‐Stadelmann, Jennifer Keiser, Robin B. Gasser, Kevin Cariou, Gilles Gasser   +14 more
wiley   +1 more source

Underexplored Ligand‐Binding Features of FabI From Staphylococcus aureus and Escherichia coli: A Comparative Pharmacophoric Modeling and Surface Mapping Approach

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Antimicrobial resistance highlights the urgent need for novel FabI inhibitors. Using an integrated computational approach combining ConPhar pharmacophore modeling, FTMap surface mapping, and PLIP interaction profiling across experimental structures and structures from MD simulations, we identified a conserved binding core (Y156/Y157, A95) and ...
Pedro Tenório T. F. Leite, Lucas H. S. Ocarino, Gabriel C. Veríssimo, Philipe O. Fernandes, Dara Fernanda Pereira, Fernanda Kelly M. e Oliveira, Alberto Marbán‐González, José L. Medina‐Franco, Mateus Sá M. Serafim, Thales Kronenberger, Vinícius G. Maltarollo   +10 more
wiley   +1 more source

Benzimidazole motifs in drug discovery: sustainable synthetic strategies and emerging biological applications. [PDF]

RSC Adv
Martis GJ, Gaonkar SL.
europepmc   +1 more source

Auto‐Click Synthesis of a Copper(I)–N‐Heterocyclic Carbene Porous Organic Polymer and Its Transmetalation to Palladium(II) for Azide–Alkyne Cycloaddition and Cross‐Coupling Reactions

European Journal of Inorganic Chemistry, Volume 29, Issue 23, 13 August 2026.
An azide‐functionalized Cu(I)–NHC complex acts as both a monomer and a catalyst in an auto‐click polymerization, yielding a Cu(I)–NHC polymer that can be transmetalated to Pd(II). The two materials catalyze copper‐catalyzed azide–alkyne cycloaddition, C–N/C–O coupling, and Suzuki–Miyaura reactions, while copper reloading restores activity.
Cyril Nicolay, Anca G. Mirea, Iuliana M. Chirica, Mihaela Florea, Arnaud Gautier, Ion Grosu, Niculina D. Hădade   +6 more
wiley   +1 more source

Electrochemical Synthesis of 1,2-Substituted <i>N</i>-Amido Benzimidazoles by Reduction of Nitroarenes. [PDF]

Org Lett
Doellerer D, Schüll A, Weyhermüller T, Beil SB, Waldvogel SR.   +4 more
europepmc   +1 more source

Triclabendazole disrupts mitochondrial electron transport <i>in vitro</i>. [PDF]

Antimicrob Agents Chemother
Kämpfer T, Ancarola ME, Zumstein P, Bernal A, Zumkehr T, Mühlemann S, Wiedemar N, Lundström-Stadelmann B.   +7 more
europepmc   +1 more source

Ligand Engineering for Precise Control of Ultrathin CsPbI3 Nanoplatelet Superlattices for Efficient Light‐Emitting Diodes

Advanced Materials, Volume 38, Issue 46, 18 August 2026.
In this work, we introduce ancillary‐ligand‐mediated growth control of ultrathin CsPbI3 PeNPLs to achieve highly uniform thickness and reduced agglomeration. Strong ancillary‐ligand coordination to the perovskite surface regulates nucleation and improves surface passivation, enabling color‐pure emission and preferentially oriented superlattices.
Jongbeom Kim, Woo Hyeon Jeong, Junzhi Ye, Allison Nicole Arber, Vikram, Donghan Kim, Yi‐Teng Huang, Yixin Wang, Dongeun Kim, Dongryeol Lee, Chia‐Yu Chang, Xinyu Shen, Sung Yong Bae, Ashish Gaurav, Ye In Kim, Jinkyu Yang, Boseung Je, Changsoon Cho, Akshay Rao, Henry J. Snaith, M. Saiful Islam, Bo Ram Lee, Myoung Hoon Song, Robert L. Z. Hoye   +23 more
wiley   +1 more source

Anthelmintic resistance in gastrointestinal nematodes of small ruminants in Southern Africa: a review and comparative analysis. [PDF]

Vet Res Commun
Mavundela S, Dzemo WD.
europepmc   +1 more source

Halide/Pseudohalide Anion Regulation of Polar Structure and Glass‐Forming Ability Toward Polar Hybrid Glass‐Ceramic

Aggregate, Volume 7, Issue 8, August 2026.
Systematic anion engineering from halide to pseudohalide (Cl− → Br− → I− → NCS−) in a family of cadmium(II)‐based organic‐inorganic hybrids drives a progressive transition from centrosymmetric to polar structure, depresses melting point, reduces fragility index, and enhances glass‐forming ability, ultimately affording a polar hybrid glass‐ceramic with ...
Ding‐Chong Han, Yu Wang, Zi‐Yi Ren, Zi‐Luo Fang, Ying‐Guang Li, Yi‐Wen Fan, Hai‐Bin Yu, Hao Zhuo, Ya‐Nan Fan, Shuai Chen, Biao Luo, Wei‐Xiong Zhang   +11 more
wiley   +1 more source