Results 101 to 110 of about 13,035 (231)

1,1‐Disubstituted Vinylbromides: Versatile Building Blocks for the Synthesis of Nitrogen‐Containing Heterocycles

European Journal of Organic Chemistry, Volume 29, Issue 23, 16 June 2026.
1,1‐Disubstituted vinylbromides are key intermediates for constructing nitrogen‐containing heterocycles. This review provides an overview of the synthetic applications of 1,1‐disubstituted vinylbromides and summarizes recent developments in reaction methodologies, mechanistic insights, and the structural diversity of N‐heterocyclic compounds accessible
Anne Westermeyer, Jun Fang, Chonghuo Liu, Guillaume Lefèvre, Gérard Guillamot, Phannarath Phansavath, Virginie Ratovelomanana‐Vidal   +6 more
wiley   +1 more source

Rh(III)‐Catalyzed [4+2] Annulation of Imidazoles With α‐Diazocarbonyl Compounds: Direct Access to π‐Conjugated Imidazole‐Fused Isoquinolinone

European Journal of Organic Chemistry, Volume 29, Issue 23, 16 June 2026.
A Rh(III)‐catalyzed [4 + 2] annulation of 2‐aryl imidazoles/benzimidazoles with α‐diazocarbonyl compounds is developed for the synthesis of π‐conjugated imidazo/benzimidazo[2,1‐a]isoquinolinones systems. Mechanistic studies and control experiment reveal that the reaction proceeds via imidazole‐directed ortho C(sp2)–H activation, followed by carbene C–H
Ganesh P. Pawar, Duc Huy Le, Li Ching Shen, Sheng‐Cih Huang, Chung‐Ming Sun   +4 more
wiley   +1 more source

The Antidepressant Drug Clomipramine Inhibits the ABC Transporter BmrA

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Drug uptake is constrained by epithelial barriers, such as the intestine and the blood–brain barrier, which express efflux pumps such as the ABC‐transporter ABCB1. Therefore, drugs targeting the central nervous system frequently require co‐administration of efflux inhibitors to facilitate sufficient target engagement. Conversely, certain drugs designed
Nadja Hellmann, Christian Kersten, Thomas Efferth, Dirk Schneider   +3 more
wiley   +1 more source

Cruzain Inhibitors for Chagas Disease: Anticorrelated Optimisation Landscapes and the Multiparametric Path to Clinical Candidates. [PDF]

Chem Biol Drug Des
Three decades of cruzain‐targeted drug discovery have yielded 215 sub‐micromolar inhibitors but no clinical candidates. This review diagnoses a systemic translational failure driven by single‐parameter optimisation and proposes a multiparametric framework integrating enzymatic potency, cathepsin selectivity, intracellular exposure, and metabolic ...
Dos Reis CRC, de Souza HVCM, Parra LC, de Souza GVCM, Zorzanelli BC, Boechat N, Hoelz LVB, Fernandes TVA.   +7 more
europepmc   +2 more sources

DNA‐Binding Properties of Iridium(III) Complexes Encompassing Design, Function and Biophysical Assessments

ChemPhysChem, Volume 27, Issue 11, 15 June 2026.
This review describes the biophysical techniques used to investigate DNA‐binding phenomena and the progress made so far in the application of iridium(III) complexes for this purpose. Ir(III) complexes offer myriad opportunities in the design and study of DNA‐binding agents and discussed examples are contextualised with complementary studies in ...
Ibrahim S. Alkhaibari, Niklaas J. Buurma, Simon J. A. Pope   +2 more
wiley   +1 more source

Electrophilic Iodination of Heterocyclic Compounds. Recent Advances 2008–2025: Part II

European Journal of Organic Chemistry, Volume 29, Issue 22, 9 June 2026.
Electrophilic iodination using molecular iodine and iodide sources represents an efficient approach for accessing valuable iodinated organic compounds. This review highlights recent advances in the iodination of heterocyclic compounds from 2008 to 2025, emphasizing the role of heteroaryl iodides as important synthetic intermediates for biologically ...
Njomza Ajvazi, Stojan Stavber
wiley   +1 more source

An Advanced Molecularly Imprinted Polymer‐Based Electrochemical Aptasensor for Carbendazim Detection

Advanced Materials Interfaces, Volume 13, Issue 12, 23 June 2026.
A dual‐recognition electrochemical aptasensor that integrates a molecular imprinted polymer (MIP) and an aptamer is developed for the detection of a common pesticide, carbendazim (CBZ). The resulting sensor exhibits enhanced selectivity toward CBZ over structurally similar compounds and achieves a low detection limit of 1.3 nm, demonstrating its ...
Suthira Pushparajah, Mahnaz Shafiei, Peter J. Mahon, Aimin Yu   +3 more
wiley   +1 more source

Benzimidazole motifs in drug discovery: sustainable synthetic strategies and emerging biological applications. [PDF]

RSC Adv
Martis GJ, Gaonkar SL.
europepmc   +1 more source

Covalent Bonds Reinforced Strength and Modulus of Heterocyclic Aramid Fiber by Interfacial Aminated‐MXene Nanosheets

Advanced Science, Volume 13, Issue 36, 29 June 2026.
We demonstrate the covalent bonds strategy to enhance the mechanical property of PBIA fiber by using interfacial MXene‐NH2 nanosheets. The MXene‐NH2 nanosheets with reactive amino sites that can serve as nucleating agents and chain anchors to enhance orientation, crystallinity and interchain interaction of PBIA fiber via strong interfacial amido ...
Boyuan Chen, Hansheng Liu, Weiheng Kong, Ke Han, Jing Fang, Xingjiang Wu, Jianhong Xu, Hao Li   +7 more
wiley   +1 more source

Electrochemical Synthesis of 1,2-Substituted <i>N</i>-Amido Benzimidazoles by Reduction of Nitroarenes. [PDF]

Org Lett
Doellerer D, Schüll A, Weyhermüller T, Beil SB, Waldvogel SR.   +4 more
europepmc   +1 more source