Results 61 to 70 of about 13,158 (230)

The Link between Protein Kinase CK2 and Atypical Kinase Rio1

Pharmaceuticals, 2017
The atypical kinase Rio1 is widespread in many organisms, ranging from Archaebacteria to humans, and is an essential factor in ribosome biogenesis. Little is known about the protein substrates of the enzyme and small-molecule inhibitors of the kinase ...
Konrad Kubiński, Maciej Masłyk
doaj   +1 more source

Interfacial Growth of 420 nm Ultrathin and Dense MOFs for Composite Electrolyte to Reduce Li+ Conduction Resistance and Inhibit Lithium Dendrite

Advanced Science, EarlyView.
In this work, an interfacial growth method using PVDF‐HFP enables controlled permeation of 2‐methylimidazole to react with Co2+, forming an ultrathin (420 nm) ZIF‐67 layer by precisely tuning the reaction time. This dense layer promotes lithium salt dissociation and suppresses dendrite growth, while its ultrathin nature reduces Li+ transport resistance,
Xinhong Qi, Zhaokai Rui, Shichen Zhang, Yihang Li, Ziyi Xin, Mengjuan Li, Lu Gao, Yuchen He, Xiaobin Jiang, Xiangcun Li, Gaohong He   +10 more
wiley   +1 more source

Design, Synthesis and Evaluation of Antiproliferative Activity of New Benzimidazolehydrazones

Molecules, 2016
The synthesis and antiproliferative activity of new benzimidazole derivatives bearing an hydrazone mojety at the 2-position is described. The new N′-(4-arylidene)-1H-benzo[d]imidazole-2-carbohydrazides were evaluated for their cytostatic activity toward ...
Valentina Onnis, Monica Demurtas, Alessandro Deplano, Gianfranco Balboni, Anna Baldisserotto, Stefano Manfredini, Salvatore Pacifico, Sandra Liekens, Jan Balzarini   +8 more
doaj   +1 more source

Accelerating Discovery of Organic Molecular Crystals via Materials Informatics and Autonomous Experiments

Advanced Intelligent Discovery, EarlyView.
Materials informatics and autonomous experimentation are transforming the discovery of organic molecular crystals. This review presents an integrated molecule–crystal–function–optimization workflow combining machine learning, crystal structure prediction, and Bayesian optimization with robotic platforms.
Takuya Taniguchi, Kazuki Ishizaki, Ryo Fukasawa   +2 more
wiley   +1 more source

In-Vitro Evaluation of Antioxidant, Antiproliferative and Photo-Protective Activities of Benzimidazolehydrazone Derivatives

Pharmaceuticals, 2020
In the search of multifunctional compounds we designed benzimidazole derivatives endowed with phenolic hydroxy groups and a hydrazone moiety as potential radical-scavenger and the antioxidant agents.
Anna Baldisserotto, Monica Demurtas, Ilaria Lampronti, Massimo Tacchini, Davide Moi, Gianfranco Balboni, Silvia Vertuani, Stefano Manfredini, Valentina Onnis   +8 more
doaj   +1 more source

Catalytic Pyrolysis of Waste Polystyrene Over Fe–B Composite Catalyst for Enhanced Liquid Fuel Production

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT Healthcare derived polystyrene waste represents a growing and under addressed fraction of plastic waste streams due to contamination risks and limited recyclability. This study aims to investigate the valorization of waste polystyrene foam through catalytic and noncatalytic pyrolysis pathways to evaluate product yield distribution and identify
Salman Khan, Zahid Hussain, Bilal Ahmad, Naveed Ahmad, Shohreh Azizi   +4 more
wiley   +1 more source

Integration of Nutrition and Organic Agriculture Framework in Managing Gastrointestinal Nematodes in Ruminants

Animal Research and One Health, EarlyView.
Gastrointestinal nematode infections damage the gastrointestinal epithelial tissues of ruminants, affecting nutrient utilization and overall production performance. This review outlines host‐gastrointestinal nematode interactions and discusses integrated control strategies, including nutritional supplementation, grazing management, vaccines, and ...
Wenxun Chen, Xiangfang Tang, Yimin Zhuang, Shengjun Zhao, Ying Ren, Xiaokang Lv   +5 more
wiley   +1 more source

Prevalence of anthelmintic resistance of gastrointestinal nematodes in Lithuanian sheep farms

Helminthologia
The rapid emergence of anthelmintic resistance (AR) among gastrointestinal nematodes (GIN) in Europe, particularly to benzimidazoles (BZ), levamisole (LEV), and macrocyclic lactones (ML), presents a growing challenge to sheep farming. This study aimed to
Beleckė A., Kupčinskas T., Adomkienė R., Stadalienė I., Várady M., Petkevičius S.   +5 more
doaj   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

La résistance aux benzimidazoles des nématodes gastro-intestinaux des petits ruminants en Gambie et au Sénégal

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1998
Cinquante-cinq troupeaux de petits ruminants en Gambie et au Sénégal ont été examinés en utilisant le test d'inhibition de l'éclosion des œufs et/ou le test de réduction des œufs de nématodes dans les fèces afin de détecter une résistance éventuelle aux
H. Bâ, S. Geerts
doaj   +1 more source