Results 141 to 150 of about 59,564 (376)

Sequential Ester Homologation–Nucleophile‐Guided Functionalization: A Chemoselective Access to Thioesters, Amides, and Acids

open access: yesChemistry–Methods, EarlyView.
The homologation of esters—in the presence of a lithium carbenoid—to thioesters, amides, and carboxylic acid is reported. By controlling the tetrahedral intermediate collapsing and promoting a series of rearrangements ultimately leading to a high electrophilic ketene, the subsequent incorporation of S‐, N‐, and O‐nucleophilic elements furnishes the ...
Davide Castiglione   +4 more
wiley   +1 more source

Visible light photoredox-catalyzed deoxygenation of alcohols

open access: yesBeilstein Journal of Organic Chemistry, 2014
Carbon–oxygen single bonds are ubiquitous in natural products whereas efficient methods for their reductive defunctionalization are rare. In this work an environmentally benign protocol for the activation of carbon–oxygen single bonds of alcohols towards
Daniel Rackl   +3 more
doaj   +1 more source

Pharmacokinetics, Safety, and Skin Irritation and Sensitization Potential of Clascoterone Cream in Early‐Phase Clinical Study Participants

open access: yesClinical Pharmacology in Drug Development, EarlyView.
Abstract Clascoterone is an androgen receptor inhibitor approved for the treatment of acne vulgaris in patients 12 years of age and older. Here, we report results of 5 phase 1 studies that assessed the pharmacokinetics (PK), safety, and skin irritation and sensitization potential of clascoterone cream 1% in healthy participants and patients with acne ...
Andrea Francesco Daniele Di Stefano   +8 more
wiley   +1 more source

Control of Circularly Polarized Luminescence in Extended Π‐Electronic Aromatics‐Based Chiral Liquid Crystals Induced by Electric Fields

open access: yesChemPhotoChem, EarlyView.
Chiral nematic liquid crystals (N*‐LC) doped with achiral fluorescent aromatic molecules emit strong circularly polarized luminescence (CPL) and act as a reversible CPL switch that can be regulated by turning the applied direct‐current electric field on and off. Chiral liquid crystals (LCs) are essential for optoelectronic devices.
Kazuki Terakubo   +5 more
wiley   +1 more source

Fluorescence Lifetime Based Probes for Water Mediated Proton Transfer and Weak Bases

open access: yesChemPhotoChem, EarlyView.
Two hydroxybenzoic acid substituted diazaoxatriangulenium (DAOTA+) fluorescence lifetime probes, is synthesized and which is capable of reporting on intra‐ and intermolecular proton transfer (PT)rates in water. Intramolecular PT in these probes only can happen via Grotthuss‐like water bridging between the carboxylate proton acceptor and the phenol ...
Marko H. Nowack, Bo W. Laursen
wiley   +1 more source

Understanding the Dissolution Kinetics of a DINCH Plasticized PVC: Experimental Design and Applied Modeling

open access: yesChemSusChem, EarlyView.
Experimental design and applied modeling of the dissolution kinetics of poly(vinyl chloride) containing di‐isononyl‐1,2‐cyclohexaandicarboxylaat (DINCH) plasticizer, with varying temperature (T), plastic particle size (dp), and solvents. Polymer dissolution‐precipitation recycling is a promising pathway to increase plastic recycling rates.
Ruben Denolf   +9 more
wiley   +1 more source

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