Results 81 to 90 of about 211,779 (381)

The Pathway to Proof‐of‐Concept for BNC210, a Negative Allosteric Modulator of the Alpha‐7 Nicotinic Acetylcholine Receptor (nAChR), for Treatment of Psychiatric Disease

Clinical Pharmacology in Drug Development, EarlyView.
Abstract BNC210 is an investigational small molecule selective negative allosteric modulator of the alpha‐7 nicotinic acetylcholine receptor (α7 nAChR). It is an anxiolytic compound with a novel mechanism of action. In a series of Phase 1 clinical trials in healthy volunteers, psychometric test batteries showed that BNC210 did not cause attention ...
Paul Rolan, Elizabeth Doolin, Dharam Paul, Julia Crossman, Michael Odontiadis, Philippe Danjou, Mark Smith, Spyros Papapetropoulos   +7 more
wiley   +1 more source

Research on 1H NMR spectrum optimization of 2,3-benzodiazepines based on conformational isomerism

Results in Chemistry
To address the issue of multiple sets of signal peaks and irregular peak shapes in the 1H NMR spectra of some 2,3-benzodiazepines due to conformational isomerism, 1H NMR experiments were conducted using 2,3-benzodiazepines 1 as examples, with variations ...
Fei Zhang, Ya-Li Ding
doaj   +1 more source

Benzodiazepines for delirium [PDF]

Cochrane Database of Systematic Reviews, 2009
Delirium occurs in 30% of hospitalised patients and is associated with prolonged hospital stay and increased morbidity and mortality. The results of uncontrolled studies have been unclear, with some suggesting that benzodiazepines may be useful in controlling non-alcohol related delirium.To determine the effectiveness and incidence of adverse effects ...
Almudena Areosa Sastre, Edmund Lonergan, Jay S. Luxenberg   +2 more
openaire   +3 more sources

Cannabidiol Lacks Direct Effect on Cortical Excitability: A Randomized, Double Blind, Placebo Controlled, 3‐Way Crossover Trial

Clinical Pharmacology &Therapeutics, EarlyView.
Cannabidiol (CBD) is approved as an adjunctive treatment of seizures associated with Dravet syndrome, Lennox–Gastaut Syndrome, and tuberous sclerosis. Its therapeutic and adverse effects are thought to arise, at least partly, from a pharmacokinetic interaction with clobazam, another anti‐seizure medication (ASM).
Andriy A. Gorbenko, Catherine M.K.E. de Cuba, Annika A. de Goede, Titiaan E. Post, Roman Bohoslavsky, Pamela K. Strugala, Jules A.A.C. Heuberger, Geert Jan Groeneveld   +7 more
wiley   +1 more source

Identifying and preventing health problems among young drug-misusing offenders [PDF]

, 2013
Purpose – The purpose of this paper is to identify the health problems and treatment needs of drug-misusing offenders and to draw out the implications of the findings for health education and prevention.
Judith Aldridge, Katy Holloway, Trevor Bennett   +2 more
core   +2 more sources

Alcohol Withdrawal Syndrome: Benzodiazepines and Beyond.

Journal of clinical and diagnostic research : JCDR, 2015
Alcohol dependence is an increasing and pervasive problem. Alcohol withdrawal symptoms are a part of alcohol dependence syndrome and are commonly encountered in general hospital settings, in most of the departments.
Ankur Sachdeva, Mona Choudhary, Mina Chandra   +2 more
semanticscholar   +1 more source

Pharmacomicrobiomics

Clinical Pharmacology &Therapeutics, EarlyView.
Oral medications encounter gut commensal microbes that participate directly and indirectly in drug effects through metabolism, interactions with drug metabolites, or production of substrates that compete with drugs for drug‐metabolizing enzymes, consequently influencing drug pharmacokinetics.
Naomi Gronich, Naama Geva‐Zatorsky, Rachel Herren, Libusha Kelly, Ziv Cohen, Haiying Zhou, Yi‐Ching Chen, Khalid Shah, Talin A. Robinson‐Catala, Grecia Frisby, Jason H. Karnes, Lisl Shoda   +11 more
wiley   +1 more source

Insights into the Silylation of Benzodiazepines Using N,O-Bis(trimethylsilyl)trifluoroacetamide (BSTFA): In Search of Optimal Conditions for Forensic Analysis by GC-MS

Molecules
Silylation is a widely used derivatization technique for the gas chromatographic analysis of benzodiazepines, a class of psychoactive drugs commonly encountered in forensic and biological samples.
Eleazar Vargas Mena, Eliana R. Herrera Giraldo, Jovanny A. Gómez Castaño   +2 more
doaj   +1 more source

Benzodiazepines and Related Drugs as a Risk Factor in Alzheimer's Disease Dementia

Frontiers in Aging Neuroscience, 2020
Benzodiazepines (BZDs) and Z-drugs are compounds widely prescribed in medical practice due to their anxiolytic, hypnotic, and muscle relaxant properties.
Miren Ettcheto, Miren Ettcheto, Miren Ettcheto, Miren Ettcheto, Jordi Olloquequi, Elena Sánchez-López, Elena Sánchez-López, Elena Sánchez-López, Oriol Busquets, Oriol Busquets, Oriol Busquets, Oriol Busquets, Amanda Cano, Amanda Cano, Amanda Cano, Patricia Regina Manzine, Carlos Beas-Zarate, Rubén D. Castro-Torres, Maria Luisa García, Maria Luisa García, Maria Luisa García, Mónica Bulló, Mónica Bulló, Mónica Bulló, Carme Auladell, Carme Auladell, Carme Auladell, Jaume Folch, Jaume Folch, Antonio Camins, Antonio Camins, Antonio Camins, Antonio Camins   +32 more
doaj   +1 more source

Emerging pharmacotherapy of tinnitus [PDF]

, 2009
Tinnitus, the perception of sound in the absence of an auditory stimulus, is perceived by about 1 in 10 adults, and for at least 1 in 100, tinnitus severely affects their quality of life.
Ana Belén Elgoyhen, Azevedo AA, Bahmad FM, Berthold Langguth, Busto U, Courtney KR, Domeisen H, Feder R, Gananca MM, Goebel G, Goodnick PJ, Gresser U, Guitton MJ, Guitton MJ, Hastak SM, Henry JA, Hilton M, Holstein N, House JW, Kuchar DL, Langguth B, Lenarz T, Mahadevan S, Mardini MK, McCabe BF, Melcher JR, Moller AR, Moller AR, Newman CW, Oliver D, Podoshin L, Richard Salvi, Rogawski MA, Roth SH, Schlee W, Shambaugh GE, Shea JJ, Shulman A, Sieghart W, Tandon R, Wei BPC, Williams SH, Willow M, Zapp JJ   +43 more
core   +1 more source