Results 101 to 110 of about 8,220 (213)

Molecular Glue Degraders Redefining Targeted Therapies From Discovery to Therapeutic Applications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Molecular glue degraders (MGDs) constitute an emerging class of therapeutic agents poised to revolutionize the paradigm of targeted drug discovery. By reprogramming E3 ubiquitin ligases to degrade proteins of interest (POI) via a transient formation of a ternary complex mediated by protein–protein interactions, MGDs surpass the intrinsic limitations of
Jinfeng Wen, Jingtian Yu, Wuqiang Wen, Baishan Jiang   +3 more
wiley   +1 more source

Synthesis of Fused and Linked Benzofurans from 2-Alkynylphenol Derivatives through Rhodium(I)-catalyzed Domino-type Addition Reactions

CHIMIA, 2018
A rhodium(I)-catalyzed domino-type sequential 5-endo/5-exo cyclization reaction of [(2-acylphenyl) ethynyl]phenols produces indene/benzofuran-fused alcohols.
Takanori Matsuda, Shinya Abe, Hirotaka Ito, Tomoya Tsuboi, Haruki Kirikae, Masahiro Murakami   +5 more
doaj   +1 more source

Mycochemical Diversity and Therapeutic Potential of Hymenochaetoid Fungi from Central Asia: Regional and Global Perspectives

New Zealand Journal of Botany, Volume 64, Issue 1, March 2026.
Central Asia harbors a rich yet understudied assemblage of wood‐inhabiting Hymenochaetoid fungi. This review delivers the first comprehensive synthesis of 43 poroid species representing 18 genera documented across montane forests, steppes, and xeric habitats.
Yusufjon Gafforov, Milena Rašeta, Sylvie Rapior, Manzura Yarasheva, Oksana Mykchaylova, Rustamjon Allaberdiev, Şule İnci, Dilfuza Berdieva, Arshad Mehmood Abbasi, Shikhnazar Khodjaev, Dian‐Ming Hu, Weijun Yang, Abudujilili Abuduaini, Maria Letizia Taddei, Mengcen Wang, Islomjon Urinboev, Jiajia Chen   +16 more
wiley   +1 more source

Halocyclization of o-(Alkynyl)styrenes. Synthesis of 3-Halo-1H-indenes [PDF]

, 2010
Junta de Castilla y Leon (BU021A09 and GR-172), Ministerio de Educacion y Ciencia (MEC), FEDER (CTQ2007-61436/BQU and CTQ2009-09949/BQU), MEC (FPU grant), Juan de la Cierva, Ramon y Cajal and "Young Foreign Researchers" (SB2009-0186 ...
Fernández Rodríguez, Manuel A., García García, Patricia, Martínez Cuezva, Alberto, Rashid, Muhammad A., Rodríguez, Félix, Sanz Díez, Roberto   +5 more
core   +1 more source

Direct Fluoroformylation of the C3‐Position of Indoles with 2,4‐Dinitro(trifluoromethoxy)benzene as Fluorocarbonyl Source

ChemistryOpen, Volume 15, Issue 3, March 2026.
Indoles bearing acyl fluoride moieties are generally obtained by dehydroxyfluorination of carboxylic acids or by fluoroformylation mediated by palladium catalysts with the disadvantage of requiring toxic reagents or very high pressures. We describe herein the direct, metal‐free, and rapid C3‐fluoroformylation of electro‐enriched indoles using ...
Lilian Wisson, Gilles Hanquet, Fabien Toulgoat, Thierry Billard, Frédéric R. Leroux, Armen Panossian   +5 more
wiley   +1 more source

Three-Component Coupling Reactions of Arynes for the Synthesis of Benzofurans and Coumarins

Molecules, 2014
The domino three-component coupling reaction of arynes with DMF and active methylenes or methines was studied as a highly efficient method for preparing heterocycles.
Eito Yoshioka, Shigeru Kohtani, Hideto Miyabe   +2 more
doaj   +1 more source

Sensitized photolysis of polychlorobiphenyls in alkaline 2-propanol: dechlorination of Aroclor 1254 in soil samples by solar radiation [PDF]

, 1992
Photodechlorination of Aroclor 1254 (1000 mg/L) in an alkaline 2-propanol solution at \lambda = 254 nm proceeded with a high quantum yield (\phi = 35.0) as determined by C1- release.
Demeter, Attila, Hawari, Jalal, Samson, Rejean   +2 more
core   +1 more source

A Novel Method Using Dual‐Energy Computed Tomography for Detecting Amiodarone‐Induced Lung Injury: A Cohort Pilot Study

Respirology, Volume 31, Issue 3, Page 276-283, March 2026.
There is no gold standard for detecting amiodarone‐induced‐lung injury (AILD). Dual‐Energy‐Computed‐Tomography (DECT) depicts iodine deposition in lungs abnormalities and the liver. We found a substantial correlation between the DECT assessment of AILD and comprehensive clinical evaluation of AILD. DECT can assist in the diagnosis of AILD.
Naama R. Bogot, Ariel Rokach, Irith Hadas‐Halperen, Yehonatan Cohen, Ayal Romem, Moshe Rav‐Acha, Tal Hasin, Gabriel Izbicki, Nissim Arish   +8 more
wiley   +1 more source

Molecular biomarkers and toxic consequences of impact by organic pollution in aquatic organisms [PDF]

, 1994
Organic contaminants are readily bioaccumulated by aquatic organisms. Exposure to and toxic effects of contaminants can be measured in terms of the biochemical responses of the organisms (i.e. molecular biomarkers).
Förlin, L., George, S.G., Livingston, D.R.   +2 more
core  

Synthesis and palladium-catalysed isomerisation of fused polycyclic tetrahydrofurans : efficient and stereoselective one-pot domino construction of functionalised bridged bicyclo[n.2.1] ring systems

, 2009
International audienceA new one-pot domino reaction for a general entry to functionalised bridged bicyclo[n.2.1] ring systems from α,α'-diactivated cyclic ketones and trans-1,4-dihalides is described.
Bensa, David, Blondeau, Fabien, Constantieux, Thierry, Rodriguez, Jean, Roger, Pierre-Yves   +4 more
core   +4 more sources