Results 91 to 100 of about 8,304 (240)

Metal‐Free Electrophilic Borylative Cyclizations of Alkynes

The Chemical Record, EarlyView.
Metal‐free borylative cyclizations based on electrophilic alkyne activation by boron Lewis acids provide efficient access to borylated hetero‐ and carbocycles. Early studies using B(C6F5)3 displayed limited scope and application, whereas recent ClBcat‐ and BCl3‐based methods enable mild CB and CC/CX bond formation for the synthesis of cycles ...
Jaime Mateos‐Gil, Marcos Humanes, Manuel A. Fernández‐Rodríguez, Patricia García‐García   +3 more
wiley   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Plasmin Regulation through Allosteric, Sulfated, Small Molecules [PDF]

, 2015
Plasmin, a key serine protease, plays a major role in clot lysis and extracellular matrix remodeling. Heparin, a natural polydisperse sulfated glycosaminoglycan, is known to allosterically modulate plasmin activity.
Al-Horani, Rami A., Desai, Umesh R., Karuturi, Rajesh, White, Domonique T.   +3 more
core   +3 more sources

Advances in organic UV filters for sunscreens over the past decade

Photochemistry and Photobiology, EarlyView.
Highlighted organic UV filter frameworks that have been described for sunscreens over the past decade divided into three groups: derivatives of or inspired by approved organic UV filters, natural product‐based compounds, and miscellaneous. Abstract Ultraviolet (UV) radiation is a major environmental factor in photoaging, erythema, and skin cancer ...
Gabriela Zanella Marcon, Maria Carolina Theisen, Andressa Motta Castro, Giovana Jones Radke, Fernando Fumagalli   +4 more
wiley   +1 more source

Palladium-Catalyzed C–H Arylation of Benzofurans with Triarylantimony Difluorides for the Synthesis of 2-Arylbenzofurans

Molecules, 2020
Pd-catalyzed regioselective C–H arylation is a useful tool for the chemical modification of aromatic heterocycles and 2-arylbenzofuran derivatives are of interest as biologically active substances. Herein, the reaction of triarylantimony difluorides with
Yuki Kitamura, Yuki Murata, Mizuki Iwai, Mio Matsumura, Shuji Yasuike   +4 more
doaj   +1 more source

Novel Psychoactive Substances: : the pharmacology of stimulants and hallucinogens [PDF]

, 2016
This is an Accepted Manuscript of an article published by Taylor & Francis in Expert Review of Clinical Pharmacology, on March 2016, available online at doi: : http://www.tandfonline.com/doi/full/10.1586/17512433.2016.1167597.There are increasing levels ...
Corkery JM, Daly M, Dargan PI, Fabrizio Schifano, Farrè M, G. Duccio Papanti, John M. Corkery, Laura Orsolini, Shulgin AT, Shulgin AT, Soussan C, Ujváry I   +11 more
core   +3 more sources

Benzofuran Derivatives : Synthesis and Screening of New Benzofuran-, 3-Methylbenzofuran- and 5-Methoxy- benzofuran-2-Carbamates and Carbamides

, 1978
Research & Development Department, Indian Drugs & Pharmaceuticals Limited, Hyderabad-500 037 Manuscript received 4 March 1978, revised 4 July 1978, accepted 27 July 1978 A number of aryl benzofuran-, 3-methylbenzofuran- and 5-metboxybenzofuran-2- carbamates and carbamides have been synthesized and screened for \(in vitro\) antibacterial ...
D. R. SHRIDHAR, C. V. REDDY SASTRY, K. B. LAL, O. P. BANSAL, S. M. SONDHI   +4 more
openaire   +1 more source

Potassium silicate improves cellular sodium homeostasis in wheat (Triticum aestivum L.) cultivars differing in salt resistance

Plant Biology, EarlyView.
Potassium silicate can decrease the uptake of sodium (Na+) into wheat cells by affecting the Na+ uptake channels and increasing ion homeostasis. Abstract Salinity causes negative impacts on crops. We investigated the effect of potassium silicate (K2SiO3) on the cytosolic uptake of sodium, [Na+]cyt, in mesophyll protoplasts of wheat cultivars differing ...
M. T. Javed, S. H. Morgan, S. Lindberg
wiley   +1 more source

Chemical Constituents from

Natural Product Communications, 2014
Three new benzofurans (1–3) and one new isoflavan (4) , pteroyanin G, H, I and J, together with 21 known compounds, were isolated from the heartwood of Pterocarpus soyauxii .
Zushang Su, Ping Wang, Wei Yuan, Shiyou Li   +3 more
doaj   +1 more source

Receptor interaction profiles of novel psychoactive tryptamines compared with classic hallucinogens [PDF]

, 2016
The present study investigated interactions between the novel psychoactive tryptamines DiPT, 4-OH-DiPT, 4-OH-MET, 5-MeO-AMT, and 5-MeO-MiPT at monoamine receptors and transporters compared with the classic hallucinogens lysergic acid diethylamide (LSD ...
Hoener, Marius C., Liechti, Matthias E., Moning, Olivier D., Rickli, Anna   +3 more
core   +1 more source