Results 111 to 120 of about 6,146 (188)
Acta Crystallographica Section D, Volume 82, Issue 9, Page 1111-1124, September 2026.We report a novel cysteine‐to‐serine surface‐mutation approach to determine co‐crystal structures of KAT6A with small‐molecule inhibitors and compare it with the previously published MYSTcryst approach which uses mutated KAT8 as a surrogate for KAT6A.
Vera Puetter +8 more
wiley +1 more source
ChemistryOpenIn this work, we developed an efficient methodology for the synthesis of benzofurans using Sonogashira‐type reactions between iodotyrosine and alkyne derivatives (aromatic, heteroaromatic, and alkyl), catalyzed by palladium salts. The methodology enabled
Giuseppe E. Figlino +6 more
doaj +1 more source
Straightforward Synthesis of Dihydrobenzofurans and Benzofurans from Arynes
, 2016 Synthesis of dihydrobenzofurans was achieved by a route involving the insertion of arynes into formamides followed by trapping with zinc enolates of α-chlorinated methines.
Hidekazu Tanaka (143503) +3 more
core +1 more source
Chemical Biology &Drug Design, Volume 108, Issue 3, September 2026.Integrating high‐throughput virtual screening, cytotoxicity assays, and molecular dynamics simulations, this study identifies the phytochemical ibs‐04156 as a reliable dual‐action candidate across both wild‐type and mutated estrogen receptor alpha (ERα), while ibs‐18821 emerges as a potent allosteric inhibitor specifically targeting the drug‐resistant ...
Dejun Jiang +6 more
wiley +1 more source
, 2016 CuI-catalyzed coupling of 1-bromo-2-iodobenzenes with β-keto esters in THF at 100 °C leads to 2,3-disubstituted benzofurans. This domino transformation involves an intermolecular C−C bond formation and a subsequent intramolecular C−O bond formation ...
Dawei Ma (275249) +3 more
core +1 more source
ChemMedChem, Volume 21, Issue 16, 27 August 2026.Four series of 20 (het)aryl substituted 7‐deazapurine nucleobases were synthesized. Several potent antagonists of all four subtypes of adenosine receptors were identified by functional assay. High‐throughput screening of the IMTM compound library for modulatory activity on adenosine receptors (ARs) identified two deazapurine hits based on 2,6‐diaryl‐7 ...
Ugnė Šinkevičiūtė +9 more
wiley +1 more source
Potential of cyclopenta[b]benzofurans from Aglaia species in cancer chemotherapy
, 2006 During the past few years, a group of cyclopenta[b]benzofurans from the plant genus Aglaia has received broad scientific attention as interesting natural product lead compounds with potential anticancer and insecticidal activities.
Douglas Kinghorn, A. +3 more
core +1 more source
Synthesis of Functionalized Chromenes and Benzofurans from Aryloxy Propargyl Malonates
, 2013 International audienceA series of aryloxy propargyl malonates was efficiently converted into various chromenes by a gold-catalyzed cyclization/Brønsted acid catalyzed isomerization sequence, and the chromenes were subsequently converted into benzofurans ...
Ikeda, K. +2 more
core +1 more source
Chinese Journal of Contemporary Neurology and Neurosurgery, 2016 Objective To investigate the effect of butylphthalide on the serum uric acid level and clinical outcomes of patients with ischemic stroke. Methods A total of 160 patients with ischemic stroke were randomly divided into 2 groups: treatment group and
Dan-dan LU +7 more
doaj
A Nickel Catalyzed Intramolecular Oxidative Coupling: Synthesis of 3-Aryl Benzofurans
, 2018 Nickel catalyzed efficient synthesis of 3-aryl benzofurans is developed from ortho-alkenyl phenols. This reaction involves an intramolecular oxidative coupling of ortho-alkenyl phenols under eco-friendly conditions and without the need of any ...
G, Satyanarayana, Aggarwal, Sakshi
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