Results 21 to 30 of about 6,146 (188)

Pharmacological profile of novel psychoactive benzofurans [PDF]

, 2015
Benzofurans are newly used psychoactive substances, but their pharmacology is unknown. The aim of the present study was to pharmacologically characterize benzofurans in vitro.; We assessed the effects of the benzofurans 5-APB, 5-APDB, 6-APB, 6-APDB, 4 ...
Simone Kopf, Anna Rickli, Liechti, Matthias E., Rickli, Anna, Hoener, Marius C., Matthias E Liechti, Kopf, Simone, Marius C Hoener   +7 more
core   +1 more source

A Recyclable Palladium-Catalyzed Synthesis of 2-Methylene-2,3-Dihydrobenzofuran-3-ols by Cycloisomerization of 2-(1-Hydroxyprop-2-ynyl)phenols in Ionic Liquids

Molecules, 2013
A recyclable palladium-catalyzed synthesis of 2-methylene-2,3-dihydrobenzofuran-3-ols 2 by heterocyclization of 2-(1-hydroxyprop-2-ynyl)phenols 1 in an ionic liquid medium (BmimBF4) is presented.
Bartolo Gabriele, Raffaella Mancuso
doaj   +1 more source

Novel benzofuran-based sulphonamides as selective carbonic anhydrases IX and XII inhibitors: synthesis and in vitro biological evaluation

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Pursuing on our efforts toward searching for efficient hCA IX and hCA XII inhibitors, herein we report the design and synthesis of new sets of benzofuran-based sulphonamides (4a,b, 5a,b, 9a–c, and 10a–d), featuring the zinc anchoring benzenesulfonamide ...
Mohamed A. Abdelrahman, Wagdy M. Eldehna, Alessio Nocentini, Hany S. Ibrahim, Hadia Almahli, Hatem A. Abdel-Aziz, Sahar M. Abou-Seri, Claudiu T. Supuran   +7 more
doaj   +1 more source

Identification of 3-(piperazinylmethyl)benzofuran derivatives as novel type II CDK2 inhibitors: design, synthesis, biological evaluation, and in silico insights

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
In the current work, a hybridisation strategy was adopted between the privileged building blocks, benzofuran and piperazine, with the aim of designing novel CDK2 type II inhibitors.
Wagdy M. Eldehna, Raed M. Maklad, Hadia Almahli, Tarfah Al-Warhi, Eslam B. Elkaeed, Mohammed A. S. Abourehab, Hatem A. Abdel-Aziz, Ahmed M. El Kerdawy   +7 more
doaj   +1 more source

Synthetic strategy toward furyl- and benzofuryl-containing building blocks for organic materials

Chimica Techno Acta, 2022
A synthetic approach to furyl- and benzofuryl-containing building blocks utilizing easily accessible substrates is reported. Cascade acid-catalyzed reactions of 2-methylfuran with α,β-unsaturated carbonyl compounds or salicyl alcohols followed by ...
Diana A. Eshmemet’eva, Danil K. Vshivkov, Yury A. Vasev, Danil A. Myasnikov   +3 more
doaj   +1 more source

Modulators of hepatic lipoprotein metabolism identified in a search for small-molecule inducers of tribbles pseudokinase 1 expression. [PDF]

PLoS ONE, 2015
Recent genome wide association studies have linked tribbles pseudokinase 1 (TRIB1) to the risk of coronary artery disease (CAD). Based on the observations that increased expression of TRIB1 reduces secretion of VLDL and is associated with lower plasma ...
Marek M Nagiec, Adam P Skepner, Joseph Negri, Michelle Eichhorn, Nicolas Kuperwasser, Eamon Comer, Giovanni Muncipinto, Aravind Subramanian, Clary Clish, Kiran Musunuru, Jeremy R Duvall, Michael Foley, Jose R Perez, Michelle A J Palmer   +13 more
doaj   +1 more source

Chemical Constituents of Stems and Leaves of Tagetespatula L. and Its Fingerprint

Molecules, 2019
Tagetespatula L. is a widely cultivated herbal medicinal plant in China and other countries. In this study, two new 2, 3-dihydrobenzofuran glucosides (1, 2) and fourteen known metabolites (3−16) were isolated from the stems and leaves of T. patula (
Yu-Meng Wang, Xiao-Ku Ran, Muhammad Riaz, Miao Yu, Qian Cai, De-Qiang Dou, Ahmed M. Metwaly, Ting-Guo Kang, De-Cheng Cai   +8 more
doaj   +1 more source

Biosynthetic pathways and related genes regulation of bioactive ingredients in mulberry leaves

Plant Signaling & Behavior, 2023
Mulberry leaves are served not only as fodder for silkworms but also as potential functional food, exhibiting nutritional and medical benefits due to the complex and diverse constituents, including alkaloids, flavonoids, phenolic acids, and benzofurans ...
Na Lu, Lei Zhang, Yuqing Tian, Jinghua Yang, Shicun Zheng, Liang Wang, Wei Guo   +6 more
doaj   +1 more source

Nickel catalyzed intramolecular oxidative coupling: synthesis of 3-aryl benzofurans

, 2020
Recent research has been focused on the transition metal-catalyzed reactions. Herein we have developed nickel-catalyzed synthesis of 3-aryl benzofurans fromortho-alkenyl phenolsviaintramolecular dehydrogenative coupling.
Srinivas, Dasari, Aggarwal, Sakshi, Sreenivasulu, Chinnabattigalla, Satyanarayana, Gedu   +3 more
core   +1 more source

Enhancement of Dissymmetry Factors Through Axial Elongation of Hetero[n]helicenes

Angewandte Chemie, EarlyView.
A benzofuran scaffolding strategy enables the synthesis of hetero[9]‐, [12]‐, and [15]helicenes. Structural and chiroptical analyses demonstrate that systematic axial elongation increases helical distortion and significantly amplifies luminescence dissymmetry.
Jeppe S. Mogensen, Christoffer Bræstrup, Christoffer Warming, Georg I. Junker, Yann Lie, Mathias Hermann, Kurt V. Mikkelsen, Michael Pittelkow   +7 more
wiley   +2 more sources