Results 81 to 90 of about 8,220 (213)

New drugs on the Internet : the case of Camfetamine [PDF]

, 2014
Copyright © 2014 Eduardo Cinosi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly ...
Acciavatti, Tiziano, Cinosi, Eduardo, Corazza, Ornella, di Giannantonio, Massimo, Lupi, Matteo, Martinotti, Giovanni, Santacroce, Rita   +6 more
core   +3 more sources

Metal‐Free Electrophilic Borylative Cyclizations of Alkynes

The Chemical Record, EarlyView.
Metal‐free borylative cyclizations based on electrophilic alkyne activation by boron Lewis acids provide efficient access to borylated hetero‐ and carbocycles. Early studies using B(C6F5)3 displayed limited scope and application, whereas recent ClBcat‐ and BCl3‐based methods enable mild CB and CC/CX bond formation for the synthesis of cycles ...
Jaime Mateos‐Gil, Marcos Humanes, Manuel A. Fernández‐Rodríguez, Patricia García‐García   +3 more
wiley   +1 more source

Suppression of lipopolysaccharide-induced COX-2 expression via p38MAPK, JNK, and C/EBPβ phosphorylation inhibition by furomagydarin A, a benzofuran glycoside from Magydaris pastinacea

Journal of Enzyme Inhibition and Medicinal Chemistry
The phytochemical investigation of the methanol extract of the seeds of Magydaris pastinacea afforded two undescribed benzofuran glycosides, furomagydarins A-B (1, 2), together with three known coumarins.
Shiu-Wen Huang, Ming Jen Hsu, Hsiu-Chen Chen, Rita Meleddu, Simona Distinto, Elias Maccioni, Filippo Cottiglia   +6 more
doaj   +1 more source

Benzofuran as a promising scaffold for the synthesis of antimicrobial and antibreast cancer agents: A review

Journal of Research in Medical Sciences, 2015
Benzofuran as an important heterocyclic compound is extensively found in natural products as well as synthetic materials. Since benzofuran drivatives display a diverse array of pharmacological activities, an interest in developing new biologically active
Ghadamali Khodarahmi, Parvin Asadi, Farshid Hassanzadeh, Elham Khodarahmi   +3 more
doaj   +1 more source

Efforts Towards Alkyne Insertion Reactions Via Oxidative Dearomatization [PDF]

, 2015
Development of 1,2-dihydro naphthalene precursors are considered to be one of the most important reactions as they form versatile framework for natural product synthesis. Efforts are on the way to develop dihydronapthalene, benzofuran and indene using an
Kumar, Rahul
core  

Synthesis of 2-BMIDA 6,5-bicyclic heterocycles by Cu(I)/Pd(0)/Cu(II) cascade catalysis of 2-iodoaniline/phenols [PDF]

, 2016
A one-pot cascade reaction for the synthesis of 2-BMIDA 6,5-bicyclic heterocycles has been developed using Cu(I)/Pd(0)/Cu(II) catalysis. 2-Iodoanilines and phenols undergo a Cu(I)/Pd(0)-catalyzed Sonogashira reaction with ethynyl BMIDA followed by in ...
Campbell, Angus, Mowat, Jenna M., Seath, Ciaran P., Watson, Allan J. B., Wilson, Kirsty L.   +4 more
core   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Structural Features Defining NF-κB Inhibition by Lignan-Inspired Benzofurans and Benzothiophenes

Biomolecules, 2020
A series of 2-arylbenzofurans and 2-arylbenzothiophenes was synthesized carrying three different side chains in position five. The synthesized compounds were tested for NF-κB inhibition to establish a structure activity relationship.
Toan Dao-Huy, Simone Latkolik, Julia Bräuer, Andreas Pfeil, Hermann Stuppner, Michael Schnürch, Verena M. Dirsch, Marko D. Mihovilovic   +7 more
doaj   +1 more source

The phytochemical composition of Melia volkensii and its potential for insect pest management [PDF]

, 2020
Due to potential health and environmental risks of synthetic pesticides, coupled with their non-selectivity and pest resistance, there has been increasing demand for safer and biodegradable alternatives for insect pest management.
Backx, Simon, Jaoko, Victor, Magomere, Titus, Mangelinckx, Sven, Mulatya, Jackson, Olubayo, Florence, Smagghe, Guy, Taning, Nji Tizi Clauvis, Van den Abeele, Jan, Werbrouck, Stefaan   +9 more
core   +2 more sources

Potassium silicate improves cellular sodium homeostasis in wheat (Triticum aestivum L.) cultivars differing in salt resistance

Plant Biology, EarlyView.
Potassium silicate can decrease the uptake of sodium (Na+) into wheat cells by affecting the Na+ uptake channels and increasing ion homeostasis. Abstract Salinity causes negative impacts on crops. We investigated the effect of potassium silicate (K2SiO3) on the cytosolic uptake of sodium, [Na+]cyt, in mesophyll protoplasts of wheat cultivars differing ...
M. T. Javed, S. H. Morgan, S. Lindberg
wiley   +1 more source