Marine Drugs, 2012 An anti-fibrotic compound produced by Streptomyces xiamenensis, found in mangrove sediments, was investigated for possible therapeutic effects against fibrosis.
Jun Xu +10 more
doaj +1 more source
Photo- and solvatochromic properties of nitrobenzospiropyran in ionic liquids containing the [NTf2]- anion [PDF]
, 2008 The photo-, thermo- and solvatochromic properties of 2,3-dihydro-10,30,30-trimethyl-6-nitrospiro- [1-benzopyran-2,20-1H-indole] (BSP-NO2) were studied in ILs containing the anion [NTf2]- by UV-Vis absorption spectroscopy, ab initio molecular orbital ...
Byrne, Robert +5 more
core +1 more source
In Vivo Metabolism Study of Xiamenmycin A in Mouse Plasma by UPLC-QTOF-MS and LC-MS/MS
Marine Drugs, 2015 Xiamenmycin A is an antifibrotic leading compound with a benzopyran skeleton that is isolated from mangrove-derived Streptomyces xiamenensis.
Feng Lei +4 more
doaj +1 more source
Epicatechin induces NF-kappa B, activator rotein-1 (AP-1) and nuclear transcription factor erythroid 2p45-related factor-2 (Nrf2) via phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT) and extracellular regulated kinase (ERK) signalling in HepG2 cells [PDF]
, 2009 The dietary flavonoid epicatechin has been reported to exhibit a wide range of biological activities. The objective of the present study was to investigate the time-dependent regulation by epicatechin on the activity of the main transcription factors (NF-
Bravo, Laura +5 more
core +4 more sources
Photoactivatable prodrugs of butyric acid based on new coumarin fused oxazole heterocycles [PDF]
, 2017 New coumarin fused oxazoles were investigated as photosensitive units for carboxylic acid groups using butyric acid as a model compound. 6-Oxo-6H-benzopyrano[6,7-d]oxazol-8-yl)methyl derivatives possessing various (hetero)aromatic substituents at ...
Ana M.S. Soares +36 more
core +1 more source
Angewandte Chemie, EarlyView.Created in BioRender. Bohg, C. (2026) https://BioRender.Com/ vi9hi4f. Rhomboid proteases are a mechanistically unique and evolutionarily conserved protein family. Despite their pharmacological relevance, the development of selective inhibitors has lagged behind that of soluble proteases.
Claudia Bohg +21 more
wiley +2 more sources
Photochromic spiropyran monolithic polymers: Molecular photo-controllable electroosmotic pumps for micro-fluidic devices [PDF]
, 2010 A novel photo-controllable micro-fluidic electroosmotic pump based on spiropyran monolithic polymers is presented here for the first time. Photochromic monolithic scaffolds have been synthesised within poly(tetrafluoroethylene) coated fused silica ...
Abele, Silvija +9 more
core +1 more source
3-Hydroxy-2-(4-methylphenyl)-4H-chromen-4-one
IUCrData, 2018 Our work in the area of carbon-monoxide-releasing molecules led to the synthesis and crystallization of new flavone derivatives as intermediates. Herein we report the first crystal structure of the title compound, C16H12O3, a hydroxy-substituted flavone ...
Clifford W. Padgett +4 more
doaj +1 more source
Methyl 2-oxo-2H-chromene-3-carboxylate [PDF]
, 2012 The title compound, C11H8O4, features an almost planar molecule (r.m.s. deviation = 0.033 Å for all non-H atoms). In the crystal, the molecules are linked via C-H...O hydrogen bonds, forming two-dimensional networks lying parallel to (1-21)
Arshad, Muhammad +3 more
core +2 more sources
AIMS Molecular Science, 2016 Leukemia cells from patients with acute myeloid leukemia (AML) display high proliferative capacity and are resistant to death. Membrane-anchored aminopeptidase-N/CD13 is a potential drug target in AML.
Brigitte Bauvois +4 more
doaj +1 more source