Results 31 to 40 of about 8,330 (182)

In Vitro and In Silico Evaluation of Cladophora sp. as an Anti-Inflammatory Agent via COX-2 (Cyclooxygenase-2) Inhibition [PDF]

BIO Web of Conferences
Cladophora sp. is known to contain chemical constituents with pharmacological properties. The secondary metabolites present in Cladophora sp. include alkaloids, phenolic compounds, saponins, and terpenoids, and it has been reported to exhibit anti ...
Bintari Yoni Rina, Kusumawati Shinta
doaj   +1 more source

A Perspective of Soy Isoflavones on Analytical, Biological, and Chemical Attributes

Legume Science, Volume 8, Issue 3, September 2026.
ABSTRACT This review covers key aspects of soybean (Glycine max), with a particular focus on its isoflavone content and biological properties. Soybeans maintain their position as both a nutraceutical and a pharmaceutical crop, with a broad range of dietary items used worldwide, including soy milk, fermented soy products, and various dietary supplements.
Sristy Suman, Joydeep Chatterjee, Gaurav Joshi, Raj Kumar, Muhammad Wahajuddin   +4 more
wiley   +1 more source

Methyl 3-(4-fluorophenyl)-1-methyl-1,2,3,3a,4,9b-hexahydrochromeno[4,3-b]pyrrole-3a-carboxylate

Acta Crystallographica Section E, 2011
In the title compound, C20H20FNO3, the pyrrolidine and benzopyran rings adopt half chair and twisted half chair conformations, respectively. The carboxylate group is almost perpendicular to the pyran ring [89.4 (1)°].
G. Chitra Devi, Sundari Bhaskaran, G. Usha, G. Murugan, M. Bakthadoss   +4 more
doaj   +1 more source

Structure‐Based Design, Synthesis, and Biological Evaluation of Oxadiazole–Morpholine Hybrids as Potent PARP‐1 Inhibitors Inducing Apoptosis in Breast Cancer Cells

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT Poly(ADP‐ribose) polymerase‐1 (PARP‐1) plays a central role in the repair of DNA single‐strand breaks and represents an established therapeutic target in cancer treatment. In this study, a series of novel oxadiazole–morpholine hybrid compounds was designed and synthesized using a structure‐based drug design approach to target the catalytic ...
Nader R. Albujuq, Khaled M. Darwish, Sherif Ashraf Fahmy, Buthaina Hussein, Ghada G. Kayed, Musa A. Said, Mohamed S. Nafie   +6 more
wiley   +1 more source

Efficacy and Tolerability of Tegoprazan Compared to Proton Pump Inhibitors in the Treatment of Erosive Esophagitis: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

JGH Open, Volume 10, Issue 8, August 2026.
ABSTRACT Aim Tegoprazan, a potassium‐competitive acid blocker, is an acid‐suppressing medication under review as a potential alternative treatment in cases of erosive esophagitis. This systematic review and meta‐analysis assesses the efficacy and tolerability of tegoprazan compared to proton pump inhibitors, the current standard of care. Methods Pubmed,
Youssef Diab, Charbel Maalouf, Anthony Junior Al Hakim, Perla Chami, Ali Ghais, Etwal Bou Raad, Louis Chaptini   +6 more
wiley   +1 more source

Crystal structure of dibromomethoxyseselin (DBMS), a photobiologically active pyranocoumarin

Acta Crystallographica Section E: Crystallographic Communications, 2017
The title compound, C15H14Br2O4 [systematic name: rac-(9S,10R)-3,9-dibromo-10-methoxy-8,8-dimethyl-9,10-dihydropyrano[2,3-h]chromen-2(8H)-one], is a pyranocoumarin derivative formed by the bromination of seselin, which is a naturally occurring angular ...
A. K. Bauri, Sabine Foro, A. F. M. M. Rahman   +2 more
doaj   +1 more source

Effect of molecular perturbation on cocrystal formation: theophylline and its 8‐halo analogues with flavonoids

Acta Crystallographica Section C, Volume 82, Issue 8, Page 414-426, August 2026.
The tendency for alkaloid–flavonoid cocrystal formation is found to be markedly different for theophylline (Tph) compared to its 8‐halo analogues. Through screening with 13 common flavonoids, Tph is found to form cocrystals with six flavonoids, whereas 8‐Cl‐Tph and 8‐Br‐Tph each form cocrystals with just two, myricetin and kaempferol.
Weijian Ye, Herman H-Y. Sung, Ian D. Williams   +2 more
wiley   +1 more source

An Efficient and Rapid Synthetic Route to Biologically Interesting Pyranochalcone Natural Products

Molecules, 2007
An efficient and concise total synthesis of naturally occurring pyranochalcones was achieved from readily available 2,4-dihydroxyacetophenone and 2,4-dihydroxy-6- methoxyacetophenone. The key steps in the synthetic strategy were ethylenediamine diacetate-
Likai Xia, Xue Wang, Yong Rok Lee
doaj   +1 more source

Synthesis of Benzopyran Atropisomers via Electrophilic Halogenation

European Journal of Organic Chemistry, Volume 29, Issue 27, 17 July 2026.
We report a halogenation‐based method for the synthesis of axially chiral benzopyrans, tolerating diverse substituents and halogens (Br, Cl, and I). A double bromination gives bisbenzopyrans with two stereogenic axes. Preliminary enantioselective conditions yield benzopyran atropisomer with up to 56% ee.
Alix Bourhis, Expédite Yen‐Pon, Jean Rodriguez, Damien Bonne   +3 more
wiley   +1 more source

Pyruvate Kinase M2 Mediates Apigenin‐Induced Energy Crisis and Apoptosis in Colon Cancer Cells

Food Frontiers, Volume 7, Issue 4, July 2026.
Apigenin, a dietary flavonoid with low toxicity, induces profound bioenergetic collapse in colon cancer cells by downregulating PKM2. This metabolic crisis, characterized by suppressed glycolysis and mitochondrial dysfunction, ultimately triggers robust apoptosis.
Ke Zhang, Xingtao Zhou, Xujie Wang, Mingyong Xie   +3 more
wiley   +1 more source