Results 181 to 190 of about 6,902 (250)

Synthesis of Isoquinolone, 1,2-Benzothiazine, and Naphtho[1',2':4,5]imidazo[1,2-a]pyridine Derivatives via Rhodium(III)-Catalyzed (4 + 2) Annulation.

Journal of Organic Chemistry, 2022
In this study, we report a novel and efficient synthetic method to construct isoquinolone scaffold via the Rh(III)-catalyzed (4 + 2) annulation of benzamide with an unreported coupling reagent methyl 2-chloroacrylate.
Yue-Hong Zhu, Rupeng Dai, Chaoqun Huang, Wang Zhou, Xiaoyuan Zhang, Kundi Yang, H. Wen, W. Li, Jian Liu   +8 more
semanticscholar   +1 more source

Discovery of (2-benzoylethen-1-ol)-containing 1,2-benzothiazine derivatives as novel 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibiting-based herbicide lead compounds

Bioorganic and Medicinal Chemistry, 2016
Kang Lei, Xue-Wen Hua, Na Liu
exaly   +2 more sources

Benzothiazines in organic synthesis. Synthesis of fluorescent 7-amino-2,1-benzothiazines

Organic & Biomolecular Chemistry, 2011
Fluorescent 7-amino-2,1-benzothiazines were prepared in high yields using the palladium-catalyzed reaction of 4-amino-2-chlorobenzaldehydes with a sulfoximine or the reaction of 7-fluoro-2,1-benzothiazines with amines.
Nattawut, Yongpruksa, Siddharth, Pandey, Gary A, Baker, Michael, Harmata   +3 more
openaire   +2 more sources

A Straightforward Synthesis of Benzothiazines

Organic Letters, 2008
A series of 4H-3,1-benzothiazines have been successfully synthesized through a three-step sequence starting from commercially available 2-iodoaniline. The key step consists of the cyclization of compounds 6 via an intramolecular S-conjugate addition. The synthesis is straightforward, gives good yields and offers a broad range of possibilities since R ...
Carolina, Gimbert, Adelina, Vallribera
openaire   +2 more sources

Synthesis, single crystal X-ray, spectroscopic and computational (DFT) studies 2,1-benzothiazine based hydrazone derivatives

, 2021
2,1-Benzothiazine-4(3H)-one 2,2-dioxide was synthesized through a multistep procedure starting with methyl anthranilate. It was reacted with hydrazine monohydrate to form corresponding hydrazine derivative which was subsequently treated with acetone and ...
Shakeel Ahmad, T. Mahmood, Matloob Ahmad, M. Arshad, Faizan Ullah, M. Shafiq, Sana Aslam, Abdullah M. Asiri   +7 more
semanticscholar   +1 more source

Synthesis and biological evaluation as well as in silico studies of arylpiperazine-1,2-benzothiazine derivatives as novel anti-inflammatory agents.

Bioorganic chemistry (Print), 2020
Novel arylpiperazine-1,2-benzothiazine derivatives have been designed and synthesized as potential anti-inflammatory agents. Their structure and properties have been studied using spectroscopic techniques (1H NMR, 13C NMR, FT-IR), MS, elemental analyses,
Berenika M. Szczęśniak-Sięga, B. Wiatrak, Ż. Czyżnikowska, J. Janczak, R. Wiglusz, J. Maniewska   +5 more
semanticscholar   +1 more source

A novel photoisomerzation of 1,2‐benzothiazine 1,1‐dioxides to 1,3‐benzothiazine 1,1‐dioxides

Journal of Heterocyclic Chemistry, 2007
AbstractA novel facile photoconversion of 4‐hydroxy‐1,2‐bezothiazine 1,1‐dioxides (3a‐e) into 4‐oxo‐1,3‐2H‐benzothiazine 1,1‐dioxides (4a‐e) and 4‐hydroxy‐2‐methyl‐N‐(pyridin‐2‐yl)‐2H‐1,2‐benzothiazine‐3‐carboxamide 1,1‐dioxide (PRX) into N‐methyl saccharin (2) upon 254 nm irradiation in methanol or acetonitrile is reported.
Ibrahim Elghamry, Dietrich Doepp, Gerald Henkel   +2 more
openaire   +1 more source

Benzothiazines in Organic Synthesis. Stereoselectivity in the Intermolecular Michael Addition Reactions of Benzothiazines

Organic Letters, 2007
A study of the intermolecular Michael addition of certain benzothiazine anions demonstrated that stereoselectivity could be extremely high, though achieving control over the direction of relative stereoselectivity was in general not straightforward.
Michael, Harmata, Yugang, Chen, Charles L, Barnes   +2 more
openaire   +2 more sources

1,4-Benzothiazines-A Biologically Attractive Scaffold

Mini-Reviews in Medicinal Chemistry, 2017
1,4-benzothiazine (1,4-B), a pharmacophore of anti-psychotic drug phenothiazines, is a vital class of heterocyclic compounds implicating versatile biological activities. The aim of this review article is to summarize various synthetic strategies, biological activities and structure activity relationship concerning the bioactive heterocycle, 1,4-B ...
Amit, Rai, Ashok K, Singh, Vinit, Raj, Sudipta, Saha   +3 more
openaire   +2 more sources

Syntheses, crystal structures, spectroscopic characterizations, DFT calculations, hirshfeld surface analyses and monte carlo simulations of novel long-chain alkyl-substituted 1,4-benzothiazine derivatives

Journal of Molecular Structure, 2020
In this work, three novel long-chain alkyl substituted 1,4-benzothiazine derivatives have been synthesized by alkylation reactions under phase transfer catalysis conditions.
Brahim Hni, N. K. Sebbar, E. Anouar, B. Ibrahimi, M. Ellouz, T. Hökelek, J. Mague, M. Urrutigoîty, N. H. Ahabchane, E. Essassi   +9 more
semanticscholar   +1 more source