Results 221 to 230 of about 153,292 (304)

A Facile Protocol for C(sp2)–C(sp3) Bond Formation Reactions Toward Functionalized E3 Ligase Ligands

ChemMedChem, EarlyView.
A robust C(sp2)–C(sp3) decarboxylative coupling strategy enables access to new CRBN ligands and degraders with improved physicochemical properties. This synthetic approach is expanding the chemical space beyond C(sp2)–N linkages, fine‐tuning proteolysis‐targeting chimera activities and unlocking previously inaccessible degrader chemotypes.
Anita Maksutova, Thomas M. Geiger, Lorenzo Cianni, Dominika E. Pieńkowska, Jan Gerhartz, Lina Read, Aleša Bricelj, Alexander Herrmann, Maurice Leon Nelles, Yuen Lam Dora Ng, Marcus D. Hartmann, Jan Krönke, Izidor Sosič, Radosław P. Nowak, Michael Gütschow, Christian Steinebach   +15 more
wiley   +1 more source

SAR Studies around the SULT1A1-Activated Alkylator YC-1 as Cytotoxic Agents against Biliary Tract Cancer Cells. [PDF]

J Med Chem
Kong K, Zhao W, Shrimp JH, Vava M, Sinha R, Sharma S, Lee TD, Roth JS, Lee OW, Lewis D, Kearney SE, Rohde JM, Davis MI, Shah P, Wang AQ, Xu X, Shi L, Shen M, Boxer MB, Bardeesy N, Hall MD, Patnaik S.   +21 more
europepmc   +1 more source

Advancing Maternal Health with Long‐Acting Therapeutics: Priorities, Efficacy and Safety Considerations, and Emerging Technologies

Clinical Pharmacology &Therapeutics, EarlyView.
Maternal health remains a critical global concern, particularly in underserved populations and in low‐ and middle‐income countries where access to safe and effective therapeutics is limited. Despite the use of medications by most women during pregnancy, the exclusion of pregnant and lactating women from clinical trials has resulted in significant data ...
Rachel K. Scott, Sharon Nachman, Ethel D. Weld, Rachel Daley, Shakir Atoyebi, Robert Bies, Catriona Waitt, Adeniyi Olagunju   +7 more
wiley   +1 more source

Stereoselective palladium-catalyzed carboetherification of cyclopropenes <i>via</i> a tethering strategy. [PDF]

Chem Sci
Brownsey DK, Schoepfer AA, Waser J.
europepmc   +1 more source

Remote Migratory Reductive Arylation of Unactivated Alkenes Enabled by Electrochemical Nickel Catalysis

ChemSusChem, Volume 18, Issue 6, March 15, 2025.
we have developed an electrochemical Ni−H catalyzed arylation coupling method of unactivated alkenes with aryl halides. The method displays broad functional group tolerance and proceeds under very mild conditions. Furthermore, aryl chlorides were also compatible substrates in this catalytic system. This conversion holds significant implications for the
Chao Xu, Ru‐Han A, Xiao‐Feng Wu
wiley   +1 more source

Unlocking the therapeutic potential of HDAC8-degrading PROTACs: progress, challenges, and future directions. [PDF]

RSC Med Chem
Banerjee S, Adhikari N, Ghosh B.
europepmc   +1 more source

Electrochemical Three‐Component Synthesis of Vinyl Sulfonamides via Decarboxylative Sulfonylation of Cinnamic Acids

ChemSusChem, EarlyView.
An efficient, metal‐free electrochemical three‐component reaction of cinnamic acids, SO2, and amines to access (E)‐β‐styryl sulfonamides is reported. Utilizing graphite electrodes and SO2 stock solutions, this decarboxylative protocol proceeds under mild conditions with high regio‐ and stereoselectivity.
Po‐Chung Chien, Harald Kelm, Georg Manolikakes   +2 more
wiley   +1 more source

Co₃O₄‑Promoted Cerium Oxide Catalyst for Efficient Catalytic <i>N</i>‑Alkylation of Amines with Alcohols. [PDF]

ACS Org Inorg Au
Kou J, Yang G, Yu Z, Liu J, Xu Y, Xin Z, Huang Y.   +6 more
europepmc   +1 more source

Biophysical processes of morphogenesis in lizard lungs

Developmental Dynamics, EarlyView.
Abstract Background The lungs of squamate reptiles (lizards and snakes) are highly diverse, exhibiting single chambers, multiple chambers, transitional forms with two to three chambers, along with a suite of other anatomical features, including finger‐like epithelial projections into the body cavity known as diverticulae.
Kaleb Hill, Aaron H. Griffing, Michael A. Palmer, Bezia Lemma, Aria S. Lupo, Tony Gamble, Natalia A. Shylo, Andrej Košmrlj, Paul A. Trainor, Celeste M. Nelson   +9 more
wiley   +1 more source

Design, Synthesis, and Evaluation of Selective Ubiquitin-Specific Protease 11 (USP11) Inhibitors. [PDF]

ACS Omega
Hassan MA, Dekker LV, Stocks MJ, Dreveny I.   +3 more
europepmc   +1 more source