Results 21 to 30 of about 153,292 (304)

Synthesis , characterization and biological activity study of N-substituted sulfonamido maleimides substituted with different heterocycles

مجلة بغداد للعلوم, 2010
Eighteen new cyclic imides (maleimides) conncted to benzothiazole moiety through sulfonamide group were synthesized via multistep synthesis.The first step involved preparation of two maleamic acids N-phenylmaleamic acid and N-benzylmaleamic acid via ...
Baghdad Science Journal
doaj   +1 more source

The discovery of potent, selective, and reversible inhibitors of the house dust mite peptidase allergen Der p 1: an innovative approach to the treatment of allergic asthma. [PDF]

, 2014
Blocking the bioactivity of allergens is conceptually attractive as a small-molecule therapy for allergic diseases but has not been attempted previously.
Anandan C., Arbes S. J., Asokananthan N., Billson J., Boyd M. J., Brown A., Brown A. D., Chan W. C., Chen J. C., Clive Robinson, Comoy E. E., David R. Garrod, Fattouh R., Gary K. Newton, Gelber L. E., Gough L., Jahnsen F. L., Jie Chen, Jihui Zhang, Jonathan P. Richardson, Kerry Jenkins, King C., Liu H., Marcaccini S., Mark R. Stewart, Meriel R. Major, Milan D. S., Moffatt M. F., Möller G. M., Nicola J. Francis-Newton, Peat J. K., Peat J. K., Pei Lai, Pichavant M., Platts-Mills T. A., Platts-Mills T. A., Platts-Mills T. A. E., Platts-Mills T. A. E., Prefontaine D., Purello-D’Ambrosia F., Rebekah E. Key, Robinson C., Silvestri M., Smith J. M., Sporik R., Squillace S. P., Steven M. Lloyd, Stewart G. A., Stuart Firth-Clark, Takai T., Trevor R. Perrior, Wan H., Ying S., Zhang J., Zhang J., Zhang J., Zhang J.   +56 more
core   +2 more sources

Corrosion Inhibition of Mild Steel by S-benzyl-O,O'-dialkyldithiophosphates in HCl Solution

International Journal of Electrochemical Science, 2018
In present work, the target compounds of S-benzyl-O,O'-dialkyldithiophosphates including S-benzyl-O,O'-diphenyldithiophosphate (Inhi-1), S-benzyl-O,O'-dibenzyldithiophosphate (Inhi-2), S-benzyl-O,O'-di(2-phenylethyl)dithiophosphate(Inhi-3) and S-benzyl-O,
Kun Wang, Chuan Lai, Banglong Tan, Bin Xie, Shasha Zhu, Hui Zhu, Ke Liu, Jian Wei   +7 more
doaj   +1 more source

Asymmetric microbial conversion of (E)-2-benzylideneindan-1-one by the filamentous fungi Botrytis cinerea, Trichoderma viride, and Eutypa lata [PDF]

, 2011
The transformation of (E)-2-benzylideneindan-1-one 1 by the filamentous fungi Botrytis cinerea, Trichoderma viride, and Eutypa lata as biocatalysts was studied.
Aleu Casatejada, Josefina, González Collado, Isidro, Pinedo Rivilla, Cristina   +2 more
core   +2 more sources

Design, synthesis, and pharmacological evaluation of haloperidol derivatives as novel potent calcium channel blockers with vasodilator activity.

PLoS ONE, 2011
Several haloperidol derivatives with a piperidine scaffold that was decorated at the nitrogen atom with different alkyl, benzyl, or substituted benzyl moieties were synthesized at our laboratory to establish a library of compounds with vasodilator ...
Yicun Chen, Jinhong Zheng, Fuchun Zheng, Jinzhi Wang, Yanmei Zhang, Fenfei Gao, Zhanqin Huang, Ganggang Shi   +7 more
doaj   +1 more source

Design, synthesis and biological evaluation of edaravone derivatives bearing the N-benzyl pyridinium moiety as multifunctional anti-Alzheimer’s agents

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
A series of multi-target directed edaravone derivatives bearing N-benzyl pyridinium moieties were designed and synthesised. Edaravone is a potent antioxidant with significant neuroprotective effects and N-benzyl pyridinium has previously exhibited ...
Luke S. Zondagh, Sarel F. Malan, Jacques Joubert   +2 more
doaj   +1 more source

Identification and Characterization of AES-135, a Hydroxamic Acid-Based HDAC Inhibitor That Prolongs Survival in an Orthotopic Mouse Model of Pancreatic Cancer [PDF]

, 2019
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive, incurable cancer with a 20% 1 year survival rate. While standard-of-care therapy can prolong life in a small fraction of cases, PDAC is inherently resistant to current treatments, and novel ...
Adile, Ashley A., Bakhshinyan, David, Berger-Becvar, Angelika, de Araujo, Elvin D., Deininger, Michael W., Fishel, Melissa L., Gawel, Justyna M., Geletu, Mulu, Grimard, Michelle L., Gunning, Patrick T., Heaton, William L., Konieczny, Stephen F., Luchman, H. Artee, O'Hare, Thomas, Raouf, Yasir, Shah, Fenil, Shouksmith, Andrew E., Singh, Sheila K., Venugopal, Chitra, Weiss, Samuel   +19 more
core   +3 more sources

Substituted (сycloalkylcarbonylthioureido)aryl-(benzyl-)carboxylic(sulfonic) acids: synthesis, antimicrobial and growth-regulating activity

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2021
Acylisothiocyanates are a promising class of organic compounds that are present in the plant world and can be used in the synthesis of disubstituted thioureas and various heterocycles.
O. V. Kholodniak, V. V. Stavytskyi, S. I. Kovalenko   +2 more
doaj   +1 more source

Galactosylsphingamides : new α-GalCer analogues to probe the F’-pocket of CD1d [PDF]

, 2017
Invariant Natural Killer T-cells (iNKT-cells) are an attractive target for immune response modulation, as upon CD1d-mediated stimulation with KRN7000, a synthetic alpha-galactosylceramide, they produce a vast amount of cytokines.
Decruy, Tine, Elewaut, Dirk, Froeyen, Mathy, Guillaume, Joren, Janssens, Jonas, Remesh, Soumya G, Risseeuw, Martijn, Van Calenbergh, Serge, Wang, Jing, Zajonc, Dirk M   +9 more
core   +1 more source

A Comparative Analysis of Floral Scent Compounds in Intraspecific Cultivars of Prunus mume with Different Corolla Colours

Molecules, 2019
Prunus mume is the only fragrant flowering species of Prunus. According to the previous studies, benzyl acetate and eugenol dominate its floral scent. However, the diversity of its floral scents remains to be elucidated.
Tengxun Zhang, Fei Bao, Yongjuan Yang, Ling Hu, Anqi Ding, Aiqin Ding, Jia Wang, Tangren Cheng, Qixiang Zhang   +8 more
doaj   +1 more source