Results 1 to 10 of about 4,626 (187)

Sulfate radical anion-induced benzylic oxidation of N-(arylsulfonyl)benzylamines to N-arylsulfonylimines [PDF]

Beilstein Journal of Organic Chemistry, 2023
A mild, operationally convenient, and practical method for the synthesis of synthetically useful N-arylsulfonylimines from N-(arylsulfonyl)benzylamines using K2S2O8 in the presence of pyridine as a base is reported herein. In addition, a “one-pot” tandem
Joydev K. Laha, Pankaj Gupta, Amitava Hazra   +2 more
doaj   +2 more sources

Bio-inspired manganese-catalyzed deaminative hydroxylation of benzyl amines to corresponding alcohols [PDF]

Nature Communications
Direct conversion of amines to corresponding alcohols is challenging even under harsh reaction conditions. Inspired by enzymatic transamination, we present a transamination borrowing-hydrogen strategy that enables the direct and selective Mn-catalyzed ...
Jiale Ji, Shiliang Wang, Zhaowen Dai, Yinghao Huo, Limin Wang, Qingshu Zheng, Tao Tu   +6 more
doaj   +2 more sources

Direct asymmetric α C(sp 3 )‒H alkylation of benzylamines with MBH acetates enabled by bifunctional pyridoxal catalysts [PDF]

Nature Communications
Organocatalytic allylic substitution of Morita-Baylis-Hillman (MBH) adducts is widely regarded as one of the most powerful transformations in organic synthesis.
Jiayao Chen, Yue Yang, Siqi Liu, Weibo Ling, Ruixin Zhang, Tongyin Chen, Wen-Wen Chen, Baoguo Zhao   +7 more
doaj   +2 more sources

Electrocatalytic hydrogenation of cyanoarenes, nitroarenes, quinolines, and pyridines under mild conditions with a proton-exchange membrane reactor [PDF]

Beilstein Journal of Organic Chemistry
An electrocatalytic hydrogenation of cyanoarenes, nitroarenes, quinolines, and pyridines using a proton-exchange membrane (PEM) reactor was developed. Cyanoarenes were then reduced to the corresponding benzylamines at room temperature in the presence of ...
Koichi Mitsudo, Atsushi Osaki, Haruka Inoue, Eisuke Sato, Naoki Shida, Mahito Atobe, Seiji Suga   +6 more
doaj   +2 more sources

Deaminative coupling of benzylamines and arylboronic acids. [PDF]

Chem Sci, 2023
A metal-free deaminative coupling of non-prefunctionalised benzylamines and arylboronic acids is reported.
Sirvinskaite G, Reisenbauer JC, Morandi B.   +2 more
europepmc   +4 more sources

NiH-catalyzed asymmetric hydroarylation of N-acyl enamines to chiral benzylamines

Nature Communications, 2021
Chiral benzylamines are found in many pharmacologically active molecules. Here, the authors report an enantio- and regio-selective reductive hydroarylation of N-acyl enamines with a NiH/chiral bis-imidazoline catalytic system affording a range of ...
Yuli He, Huayue Song, Jian Chen, Shaolin Zhu   +3 more
doaj   +1 more source

Synthesis of 1,5-Substituted Pyrrolidin-2-ones from Donor–Acceptor Cyclopropanes and Anilines/Benzylamines

Molecules, 2022
We developed a straightforward synthetic route to pharmacologically important 1,5-substituted pyrrolidin-2-ones from donor–acceptor cyclopropanes bearing an ester group as one of the acceptor substituents.
Maksim A. Boichenko, Andrey Yu. Plodukhin, Vitaly V. Shorokhov, Danyla S. Lebedev, Anastasya V. Filippova, Sergey S. Zhokhov, Elena A. Tarasenko, Victor B. Rybakov, Igor V. Trushkov, Olga A. Ivanova   +9 more
doaj   +1 more source

Benzylamines as highly potent inhibitors of the sterol biosynthesis pathway in Leishmania amazonensis leading to oxidative stress and ultrastructural alterations

Scientific Reports, 2022
Leishmaniasis is a neglected disease caused by protozoan parasites of the Leishmania genus. Benzylamines are a class of compounds selectively designed to inhibit the squalene synthase (SQS) that catalyzes the first committed reaction on the sterol ...
Sara Teixeira de Macedo-Silva, Gonzalo Visbal, Gabrielle Frizzo Souza, Mayara Roncaglia dos Santos, Simon B. Cämmerer, Wanderley de Souza, Juliany Cola Fernandes Rodrigues   +6 more
doaj   +1 more source

Alkaloids Modulate the Functioning of Ion Channels Produced by Antimicrobial Agents via an Influence on the Lipid Host

Frontiers in Cell and Developmental Biology, 2020
It is widely recognized that an alteration in membrane physical properties induced by the adsorption of various drugs and biologically active compounds might greatly affect the functioning of peptides and proteins embedded in the membrane, in particular ...
Svetlana S. Efimova, Anastasiia A. Zakharova, Olga S. Ostroumova   +2 more
doaj   +1 more source

Benzobicyclo[3.2.1]octene Derivatives as a New Class of Cholinesterase Inhibitors

Molecules, 2020
A library of amine, oxime, ether, epoxy and acyl derivatives of the benzobicyclo[3.2.1]octene were synthesized and evaluated as inhibitors of both human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE).
Tena Čadež, Ana Grgičević, Ramiza Ahmetović, Danijela Barić, Nikolina Maček Hrvat, Zrinka Kovarik, Irena Škorić   +6 more
doaj   +1 more source